CD135 / FLT3 antibody

Principal name

CD135 / FLT3 antibody

Alternative names for CD135 / FLT3 antibody

FL cytokine receptor, STK1, Tyrosine-protein kinase receptor FLT3, Stem cell tyrosine kinase 1

SwissProt ID

P36888 (Human), Q00342 (Mouse)

Gene ID

2322 (FLT3), 14255 (Flt3)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Mky (Monkey)

Available hosts

Goat, Rabbit, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP), Functional assay (FN)

Background of CD135 / FLT3 antibody

Flt3/Flk2 Ligand (FL) is produced from a DNA sequence encoding amino acid residues 1 to 185 polypeptide of Flt3/Flk2 ligand. The 159 amino acid residue recombinant protein, generated after removal of the 26 amino acid residue signal peptide, has a predicted molecular mass of approximately 17.5 kDa. The gene for FL has been mapped to chromosomes 19q13.3 and 13q12-q13 in humans. The Flt3 (fms-like tyrosine kinase 3)/Flk2 (fetal liver kinase 2) Ligand (FL), a hematopoietic cytokine, was cloned based on its ability to bind and activate c-kit and Flt3 tyrosine kinase receptors. Fl plays a key role in hematopoiesis by stimulating proliferation and/or differentiation of various hematopoietic cell types in vitro as well as in vivo. Human FL, a type I transmembrane glycoprotein, is biologically active on the cell surface and can be cleaved to generate a soluble form that is also biologically active. Also, an alternatively spliced soluble isoform of FL has been identified in both human and mouse. Human and mouse FL share 72% amino acid sequence homology and exhibit full species cross-reactivity.FL has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors. FL promotes growth of early B cell progenitor cells in combination with IL-7 and induces adhesion of the precursor B cell line Baflt3 to fibronectin by activating the fibronectin receptors VLA-4 and VLA-5 integrins. Flt3/Flk2 ligand is widely expressed in a variety of tissues. Cells known to express FL include T cell lines, a thymic stromal cell line 1, and bone marrow fibroblasts. In hematopoietic cells, the expression of Flt3/Flk2 is restricted to the population enriched for precursor/progenitor cells.

General readings

Rosnet O, Schiff C, Pebusque MJ, et al. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 1993; 82:1110-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD135 / FLT3 antibody

Immunofluorescence staining of methanol-fixed HeLa cells using FLT3 antibody (red). Rabbit IgG Purified Hu ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD135 / FLT3 (N-term) antibody

Western blot analysis of FLT3 in 3T3 cell lysate with FLT3 antibody at (A) 1 and (B)2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD135 / FLT3 antibody

CD135 / FLT3 Rat A2F10 Purified Ms F, IP
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD135 / FLT3 antibody

CD135 / FLT3 Rat AFL4 Purified Ms F, IP, P, WB
50 µg / €120.00
  OriGene Technologies, Inc.

CD135 / FLT3 antibody

CD135 / FLT3 Mouse BV10A4H2 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

CD135 / FLT3 (N-term) antibody

Western blot analysis of anti-FLT3 Pab (Cat. #TA324962) in HL-60 cell lysate. FLT3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD135 / FLT3 antibody

Anti-FLT3 / CD135 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

CD135 / FLT3 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT3 (RC211459, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT3.(1:500) Mouse IgG1 OTI7D6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD135 / FLT3 antibody

CD135 / FLT3 Mouse IgG1 BV10A4 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD135 / FLT3 antibody

CD135 / FLT3 Mouse IgG1 BV10A4 Aff - Purified Hu F, IP

Regular Price: 0.1 mg / €210.00

Special Price: 0.1 mg / €133.00

  Acris Antibodies GmbH

CD135 / FLT3 antibody

CD135 / FLT3 Mouse IgG1 BV10A4 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD135 / FLT3 antibody

Western blot (WB) analysis of Flt3 antibody (Cat.-No.: AP01277PU-N) in extracts from MCF-7 cells. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD135 / FLT3 (Internal) antibody

Interfollicular Zone: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hst, Hu, Mky, Prim, Rb E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD135 / FLT3 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using AP09468PU FLT3 Antibody (Red). Rabbit Aff - Purified Hu ICC/IF, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

CD135 / FLT3 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using AP09468PU FLT3 Antibody (Red). Rabbit Aff - Purified Hu ICC/IF
50 µl / €230.00
  Acris Antibodies GmbH

CD135 / FLT3 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD135 / FLT3 pTyr591 antibody

Immunohistochemistry (IHC) analyzes of p-FLT3 antibody (Cat.-No.: AP20941PU-N) in paraffin-embedded human lung adenocarcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

CD135 / FLT3 antibody

Immunohistochemistry (IHC) analyzes of FLT3 antibody (Cat.-No.: AP21030PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

CD135 / FLT3 (N-term) Control Peptide

CD135 / FLT3
50 µg / €160.00
  Acris Antibodies GmbH

CD135 / FLT3 pTyr842 antibody

Western blot analysis of extracts from HepG2 cells treated with EGF using FLT3 (Phospho-Tyr842)) Antibody AP55755PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €340.00
  Acris Antibodies GmbH

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