CD136 / MST1R antibody

Principal name

CD136 / MST1R antibody

Alternative names for CD136 / MST1R antibody

Macrophage-Stimulating 1 Receptor, PTK8, RON, p185-Ron, MSP receptor, Macrophage-stimulating protein receptor, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain

SwissProt ID

Q04912 (Human), Q62190 (Mouse)

Gene ID

4486 (MST1R)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Dot blot (Dot), Neutralisation (NEUT)

Background of CD136 / MST1R antibody

CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d?origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades, such as MAPK, PI3K/AKT, FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. CD136 is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD136 / MST1R antibody

Western blot analysis of extracts from HepG2 cells, using RON (Ab-1353) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Anti-MST1R / RON antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Anti-MST1R / RON antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms P
50 µg / €379.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Anti-MST1R / RON antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Anti-MST1R / RON antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Western blot analysis on HeLa cell lysate using RON Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD136 / MST1R antibody

Western blot analysis using RON antibody AM06266SU-N against HCC827 (Lane 1), HT-29 (Lane 2), HCT-116 (Lane 3) and BxPC-3 (Lane 4) cell lysate. Mouse IgG1 1B5A9 Ascites Hu WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CD136 / MST1R antibody

Western blot analysis of anti-RON Antibody Cat.-No AP14419PU-N in THP1 cell lysate. RON (arrow) was detected using purified Pab. Secondary HRP-anti-Rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD136 / MST1R antibody

Western blot analysis of RON Antibody Cat.-No AP18183PU-N in HL-60 cell line lysates (35 ug/lane). RON (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD136 / MST1R antibody

Detection limit for recombinant GST tagged MST1R is approximately 1ng/ml as a capture antibody. Mouse IgG2a 4E2 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

Detection limit for recombinant GST tagged MST1R is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 1H8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

Detection limit for recombinant GST tagged MST1R is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 1H7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

Detection limit for recombinant GST tagged MST1R is approximately 1ng/ml as a capture antibody. Mouse IgG2a 2F3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

Detection limit for recombinant GST tagged MST1R is approximately 1ng/ml as a capture antibody. Mouse IgG2a 3H2 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

The cell lysate derived from MSP-treated MST1R transfected HEK 293 were immunoprobed by MST1R ( phospho Y1238 ) polyclonal antibody ( Cat # PAB12611 ) at 1 : 500. An immunoreactive band is observed around ~185kDa ( lane 1 ). This band is blocked by immunizing peptide ( lane 2 ). Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

The cell lysate derived from MSP-treated MST1R transfected HEK 293 were immunoprobed by MST1R ( phospho Y1238/Y1239 ) polyclonal antibody ( Cat # PAB12612 ) at 1 : 500. An immunoreactive band is observed around ~185kDa ( lane 1 ). This band is blocked by immunizing peptide ( lane 2 ). Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

The cell lysate derived from MSP-treated MST1R transfected HEK 293 were immunoprobed by MST1R ( phospho Y1239 ) polyclonal antibody ( Cat # PAB12613 ) at 1 : 500. An immunoreactive band is observed around ~185kDa ( lane 1 ). This band is blocked by immunizing peptide ( lane 2 ). Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

The cell lysate derived from MSP-treated MST1R transfected HEK 293 were immunoprobed by MST1R polyclonal antibody ( Cat # PAB12664 ) at 1 : 500. An immunoreactive band is observed around ~185kDa ( lane 1 ). This band is blocked by immunizing peptide ( lane 2 ). Rabbit Hu, Ms, Rt C, Dot, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD136 / MST1R antibody

CD136 / MST1R Rabbit Hu, Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD136 / MST1R pSer1394 antibody

Western blot analysis of extracts from HeLa cells treated with TNF-a 20ng/ml 2', using CD136/RON (Phospho-Ser1394) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

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