CD137 / TNFRSF9 antibody

Principal name

CD137 / TNFRSF9 antibody

Alternative names for CD137 / TNFRSF9 antibody

4-1BB ligand receptor, 4-1BB homolog, ILA, CDw137, Tumor necrosis factor receptor superfamily member 9, T-cell antigen 4-1BB homolog, T-cell antigen ILA

SwissProt ID

P20334 (Mouse), Q07011 (Human)

Gene ID

3604 (TNFRSF9), 21942 (Tnfrsf9)

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Bab (Baboon), Rt (Rat), Prim (Primate), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Goat, Mouse, Rat, Rabbit, Hamster

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Functional assay (FN), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Neutralisation (NEUT)

Background of CD137 / TNFRSF9 antibody

4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9. Mouse 4-1BB cDNA encodes a 256 amino acid (aa) residues type I transmembrane protein with a putative 23 aa signal peptide, a 164 aa extracellular domain, a 21 aa transmembrane domain and a 48 aa cytoplasmic region. A soluble 4-1BB is released from surfaces of cells expressing the transmembrane protein. Mouse4-1BB shares approximately 60% aa sequence identity with its human counterpart. 41BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils. The ligand for 4-1BB (4-1BBL), also named TNFSF9, belongs to the TNF ligand superfamily. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. In response to 4-1BBL binding, 4-1BB transduce a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In vivo, the costimulatory activity of 4-1BB has been shown to be important in graftv shost disease and antiviral CTL responses. On dendritic cells, 4-1BB is a DCactivating molecules that enhances cytokine production and upregulates expression of B71 and B72 costimulatory molecules, resulting in an improved ability to stimulate T cell responses.

General readings

Litjens NH., et al. (2013) Clin. Exp. Immunol. 174:179-191.Lee SJ., et al. (2013) Eur. J. Immunol. 43:1839-1848.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD137 / TNFRSF9 antibody

To detect h4-1BB Receptor by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant h4-1BB Receptor. Goat IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD137 / TNFRSF9 antibody

To detect h4-1BB Receptor by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human 4-1BB Receptor (TA328256) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant h4-1BB Receptor. Goat IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD137 / TNFRSF9 antibody

Western Blot: CD137 Antibody [TA337208] - WB detection of CD137 partial recombinant protein by using CD137 antibody at a concentration of 0.01 ug/ml. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD137 / TNFRSF9 antibody

Lanes: Lane 1: 40ug whole canine retina; Primary Antibody Dilution: 1:1000; Secondary Antibody: Goat anti-rabbit-HRP; Secondary Antibody Dilution: 1:5000; Gene Name: TNFRSF; Submitted by: Dr. Stefania Marsili and Dr. William Beltran, University of Pennsyl Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD137 / TNFRSF9 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF9 (RC200664, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF9. Mouse IgG1 OTIH5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD137 / TNFRSF9 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF9 (RC200664, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF9. Mouse IgG1 OTIF9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Rat IgG2a JG1.6A Purified Hu, Mky E, F, FN
0.2 mg / €430.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Rat IgG2a JG1.6A Purified Hu, Mky E, F, FN
25 µg / €180.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

Western blot (WB) analysis of CD137 antibody (Cat.-No.: AP06718PU-N) at 1/500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 (Extracell. Dom.) antibody

CD137 / TNFRSF9 Rat IgG2 4G33 Purified Ms F, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Goat Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Goat Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Goat Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Mouse IgG1 4B4-1 Purified Hu, Prim E, F, FN, IP
0.1 mg / €210.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Rat IgG2a LOB12 Purified Ms F
0.25 mg / €400.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

CD137 / TNFRSF9 Rat IgG2a LOB12 Purified Ms F
25 µg / €170.00
  Acris Antibodies GmbH

CD137 / TNFRSF9 antibody

Western blot analysis of TNFRSF9 using 50 µg recombinant human TNFRSF9. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD137 / TNFRSF9 antibody

Western blot analysis of extracts from K562 cells, using TNFRSF9 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

CD137 / TNFRSF9 antibody

Western blot analysis of extracts from K562 cells, using TNFRSF9 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

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