CD138 / Syndecan-1 antibody

Principal name

CD138 / Syndecan-1 antibody

Alternative names for CD138 / Syndecan-1 antibody

SYND1, SDC1, SDC

SwissProt ID

P18827 (Human), P18828 (Mouse), P26260 (Rat), Q08DZ5 (Bovin)

Gene ID

6382 (SDC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of CD138 / Syndecan-1 antibody

CD138, also known as Syndecan-1, is a transmembrane heparin sulfate proteoglycan that binds type I collagen. The relative molecular mass of CD138 is found to vary between 20-95 kDa due to the presence of a variable number of GAG modifications on each CD138 molecule. This protein appears to mediate binding of cells to the extracellular matrix. Among mature tissues, CD138 is expressed on simple and stratified epithelia, endothelial cells, and fibroblasts. (Ref.1,2) While stratified keratinocytes express CD138, their malignant transformation suppresses CD138 expression. Wound repair processes alter patterns of CD138 expression. Among hematopoietic cells, CD138 is expressed by immunoglobulin-negative pre-B cells in the bone marrow, immature B cells and by terminally differentiated plasma cells in lymphoid organs. CD138 expression has not been observed on mature, circulating peripheral B lymphocytes, however. (Ref.3-6)
CD138 is also strongly expressed by multiple myeloma-derived cell lines and elevated levels of CD138 are present in the serum of patients with multiple myeloma, a negative prognostic indicator for the disease. (Ref.7)

General readings

1. Hayashida K, Johnston DR, Goldberger O, Park P.W.: Syndecan-1 expression in epithelial
cells is induced by transforming growth factor beta through a PKA-dependent pathway. J
Biol Chem. 2006 Aug 25;281(34):24365-74.
2. Choi DS, Kim JH, Ryu HS, Kim HC, Han JH, Lee JS, Min C.K.: Syndecan-1, a key
regulator of cell viability in endometrial cancer. Int J Cancer. 2007 Aug 15;121(4):741-50.
3. Manakil JF, Seymour GJ, Bartold P.M.: Effect of cytokine and antigen stimulation on
peripheral blood lymphocyte syndecan-1 expression. Oral Microbiol Immunol. 2007
Aug;22(4):272-6.
4. Muto T, Miyoshi K, Munesue S, Nakada H, Okayama M, Matsuo T, Noma T.: Differential
expression of syndecan isoforms during mouse incisor amelogenesis. J Med Invest. 2007
Aug;54(3-4):331-9.
5. Ojeh N, Hiilesvuo K, Wärri A, Salmivirta M, Henttinen T, Määttä A.: Ectopic expression of
syndecan-1 in basal epidermis affects keratinocyte proliferation and wound
re-epithelialization. J Invest Dermatol. 2008 Jan;128(1):26-34.
6. Jilani I, Wei C, Bekele BN, Zhang ZJ, Keating M, Wierda W, Ferrajoli A, Estrov Z, Kantarjian H, O'Brien SM, Giles FJ, Albitar M.: Soluble syndecan-1 (sCD138) as a prognostic factor independent of mutation status in patients with chronic lymphocytic leukemia. Int J Lab Hematol. 2008 Jan 7.
7. Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD: The syndecan-1 heparan sulfate
proteoglycan is a viable target for myeloma therapy. Blood. 2007 Sep 15;110(6):2041-8.
8. Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC: G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. J Clin Invest. 2007 Oct;117(10):3107-17.
9. Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R: Essential
role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B
cell collaboration. J Immunol. 2007 Nov 1;179(9):5886-96.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse IgG1 B-A38 Azide Free Hu C, F, P
0.1 mg / €250.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 (18-218) antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with SDC1 antibody AP22709PU-N at 15 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
50 µg / €470.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit IgG SP152 Purified Hu P
0.5 ml / €510.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit IgG SP152 Purified Hu P
1 ml / €730.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit IgG SP152 Purified Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit Purified Hu P
1 ml / €440.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Human tonsil stained with anti-CD138 antibody Rabbit Purified Hu P
0.1 ml / €180.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse DL-101 Purified Hu F, P
0.1 mg / €130.00
  OriGene Technologies, Inc.

CD138 / Syndecan-1 antibody

TA326738 (1µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD138 / Syndecan-1 antibody

Western blot analysis of Raji cell and Hela cell lysate using SDC1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD138 / Syndecan-1 antibody

Immunohistochemistry staining of Paraffin Tonsil tissue by CD138 antibody (dilution: 1:25 - 1:200; visualization of staining: Membranous) Mouse IgG1 B-A38 Purified Hu P
1 ml / €690.00
  OriGene Technologies, Inc.

CD138 / Syndecan-1 antibody

ELISA: Syndecan 1 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse IgG1 B-A38 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

Flow cytometry: A typical staining pattern using U266 cell line with the B-A38 monoclonal antibody cat. no. AM03022AF-N Mouse IgG1 B-A38 Azide Free Hu C, F, P
0.2 mg / €310.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

A typical staining pattern with the B-A38 monoclonal antibody of U266 cell line Mouse IgG1 B-A38 Biotin Hu C, F, P
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse IgG1 B-A38 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

A typical staining pattern with B-A38 monoclonal antibody of RPMI 8226 cell line Mouse IgG1 B-A38 PerCP Hu F
1ml (100T) / €300.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse IgG1 B-A38 Purified Hu C, F, P
2.5ml (50T) / €240.00
  Acris Antibodies GmbH

CD138 / Syndecan-1 antibody

CD138 / Syndecan-1 Mouse IgG1 B-A38 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

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