CD141 / THBD antibody
Principal name
CD141 / THBD antibody
Alternative names for CD141 / THBD antibody
Thrombomodulin, THRM, Fetomodulin
Ncbi ID
Available reactivities
Available hosts
Available applications
Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Functional assay (FN), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)
Background of CD141 / THBD antibody
The protein C anticoagulant pathway serves as a major system for controlling coagulation and limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. Thrombomodulin binds thrombin, directly inhibiting its clotting and cell activation potential while at the same time augmenting protein C. The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-TM complex more than 10-fold. TM also accelerates thrombin activation of a plasma procarboxypeptidase B, named thrombin activatable fibrinolysis inhibitor or TAFI resulting in slowing clot lysis. The inhibited thrombin rapidly dissociates from thrombomodulin, regenerating the anticoagulant surface. Thrombomodulin also has direct anti-inflammatory activity, minimizing cytokine formation in the endothelium and decreasing leukocyte-endothelial cell adhesion. Thrombomodulin inhibits leukocyte binding to activated endothelium.
TM has been detected in a variety of cells and tissues in adults and during development, including astrocytes in the brain, keratinocytes, endothelial cells, mesothelial cells of the peritoneum, and circulating neutrophils, monocytes, and platelets. During fetal development, TM plays a central role in controlling the growth and survival of trophoblast cells in the placenta, a function essential for the maintenance of pregnancy.
Thrombin binding to thrombomodulin involves anion binding exosite 1 on thrombin and epidermal growth factor (EGF) domains 4 to 6 on thrombomodulin.
General readings
Dane, M. J. C. et al., Clin. J. Am. Soc. Nephrol.,2014;9(4): 698-704





Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA308080 | CD141 / THBD antibody |
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Rabbit Polyclonal antibody to Thrombomodulin (thrombomodulin) | |||||||
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Rabbit | IgG | Aff - Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€416.00
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OriGene Technologies, Inc. | |||||||
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TA314621 | CD141 / THBD antibody |
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Rabbit polyclonal anti-THBD antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA327745 | CD141 / THBD antibody |
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Mouse Monoclonal Thrombomodulin Antibody | |||||||
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Mouse | IgG1 | 1009 | Purified | Hu | P |
1 ml /
€680.00
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OriGene Technologies, Inc. | |||||||
AM26231PU-N | CD141 / THBD (EGF6 Dom) antibody |
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Rat | IgG2a | RTM98 | Purified | Hu | F, FN, WB |
0.1 mg /
€410.00
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Acris Antibodies GmbH | |||||||
AM26232PU-N | CD141 / THBD (EGF4 Dom.) antibody |
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Rat | IgG2a | RTM96 | Purified | Hu | F, FN, WB |
0.1 mg /
€410.00
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Acris Antibodies GmbH | |||||||
AM31356AF-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-A35 | Azide Free | Hu | F |
0.2 mg /
€270.00
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Acris Antibodies GmbH | |||||||
AM31356FC-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-A35 | FITC | Hu | F |
1ml (100T) /
€270.00
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Acris Antibodies GmbH | |||||||
AM31356PU-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-A35 | Purified | Hu | F |
2ml (200T) /
€250.00
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Acris Antibodies GmbH | |||||||
AM31360AF-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-A35 | Azide Free | Hu | E(capture) |
1 mg /
€790.00
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Acris Antibodies GmbH | |||||||
AM31361AF-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-S24 | Azide Free | Hu | E |
0.2 mg /
€270.00
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Acris Antibodies GmbH | |||||||
AM31361BT-N | CD141 / THBD antibody |
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Mouse | IgG1 | B-S24 | Biotin | Hu | E(detection) |
0.1 mg /
€460.00
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Acris Antibodies GmbH | |||||||
SM1201 | CD141 / THBD antibody |
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Mouse | IgG2a | QBEND/40 | Supernatant | Hu, Rb | C, F, ICC/IF, P |
1 ml /
€490.00
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Acris Antibodies GmbH | |||||||
SM1201T | CD141 / THBD antibody |
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Mouse | IgG2a | QBEND/40 | Supernatant | Hu, Rb | C, F, P |
0.1 ml /
€210.00
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Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN207598BN | THBD - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN207598LP | THBD - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN207598RB | THBD - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP723443 | CD141 / THBD |
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Purified recombinant protein of Human thrombomodulin (THBD). | |||||
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Human | > 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
10 µg /
€239.00
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|
OriGene Technologies, Inc. | |||||
ELISA Kits
Catalog No. | ||
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EA101199 | Human CD141 ELISA Kit |
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1 kit /
€224.00
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OriGene Technologies, Inc. | ||
EA101200 | Human CD141 ELISA Kit |
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1 kit /
€401.00
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OriGene Technologies, Inc. | ||
EA101201 | Human CD141 ELISA Kit |
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1 kit /
€620.00
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OriGene Technologies, Inc. |