CD141 / THBD antibody

Principal name

CD141 / THBD antibody

Alternative names for CD141 / THBD antibody

Thrombomodulin, THRM, Fetomodulin

SwissProt ID

P06579 (Bovin), P07204 (Human), P15306 (Mouse), Q5W7P8 (Canfa)

Gene ID

7056 (THBD), 21824 (Thbd)

Available reactivities

Hu (Human), Rb (Rabbit), Rt (Rat), Ms (Mouse)

Available hosts

Mouse, Rabbit, Rat

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Functional assay (FN)

Background of CD141 / THBD antibody

Monoclonal antibody RTM96 recognizes thrombomodulin (a C-type lectin also known as CD141), a complex molecule located on the endothelium and a key feature in the protein C pathway. The protein C anticoagulant pathway serves as a major system for controlling coagulation and limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. Thrombomodulin binds thrombin, directly inhibiting its clotting and cell activation potential while at the same time augmenting protein C. The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-TM complex more than 10-fold. TM also accelerates thrombin activation of a plasma procarboxypeptidase B, named thrombin activatable fibrinolysis inhibitor or TAFI resulting in slowing clot lysis. The inhibited thrombin rapidly dissociates from thrombomodulin, regenerating the anticoagulant surface. Thrombomodulin also has direct anti-inflammatory activity, minimizing cytokine formation in the endothelium and decreasing leukocyte-endothelial cell adhesion. Thrombomodulin inhibits leukocyte binding to activated endothelium. TM has been detected in a variety of cells and tissues in adults and during development, including astrocytes in the brain, keratinocytes, endothelial cells, mesothelial cells of the peritoneum, and circulating neutrophils, monocytes, and platelets. During fetal development, TM plays a central role in controlling the growth and survival of trophoblast cells in the placenta, a function essential for the maintenance of pregnancy. Thrombin binding to thrombomodulin involves anion binding exosite 1 on thrombin and epidermal growth factor (EGF) domains 4 to 6 on thrombomodulin. The monoclonal antibody RTM96 reacts with the EGF4 domain, thereby inhibiting the biological activity of thrombomodulin.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD141 / THBD antibody

Immunohistochemistry-Paraffin: Thrombomodulin Antibody (EPR4051) [NBP1-95319] - Analysis of paraffin-embedded human squamous cervical carcinoma tissue using anti-Thrombomodulin . Rabbit EPR4051 Purified Hu ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

CD141 / THBD antibody

Sample (30 ug of whole cell lysate). A: THP-1. 7.5% SDS PAGE. TA308080 diluted at 1:500. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD141 / THBD antibody

Western blot analysis of extracts from K562 cells, using THBD antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD141 / THBD antibody

Immunohistochemistry staining of Paraffin Bladder, mesothelioma tissue by Thrombomodulin antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous, cytoplasmic) Mouse IgG1 1009 Purified Hu P
1 ml / €570.00
  OriGene Technologies, Inc.

CD141 / THBD (EGF6 Dom.) antibody

CD141 / THBD Rat IgG2a RTM98 Purified Hu F, FN, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD141 / THBD (EGF4 Dom.) antibody

CD141 / THBD Rat IgG2a RTM96 Purified Hu F, FN, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD141 / THBD antibody

A typical staining pattern with the B-A35 monoclonal antibody of monocytes. Mouse IgG1 B-A35 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD141 / THBD antibody

A typical staining pattern with the B-A35 monoclonal antibody of monocytes. Mouse IgG1 B-A35 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD141 / THBD antibody

A typical staining pattern with the B-A35 monoclonal antibody of monocytes. Mouse IgG1 B-A35 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD141 / THBD antibody

CD141 / THBD Mouse IgG1 B-A35 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD141 / THBD antibody

CD141 / THBD Mouse IgG1 B-S24 Azide Free Hu E
0.2 mg / €270.00
  Acris Antibodies GmbH

CD141 / THBD antibody

CD141 / THBD Mouse IgG1 B-S24 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD141 / THBD antibody

CD141 - SM1201 - Human lymph node. Formalin fixed, paraffin processed tissue. Mouse IgG2a QBEND/40 Supernatant Hu, Rb C, F, ICC/IF, P
1 ml / €480.00
  Acris Antibodies GmbH

CD141 / THBD antibody

Immunohistochemistry: SM1201T CD141 antibody staining of Formalin Fixed, Paraffin Human lymph node tissue. Mouse IgG2a QBEND/40 Supernatant Hu, Rb C, F, P
10 Tests / 0.1 ml / €210.00
  Acris Antibodies GmbH

CD141 / THBD antibody

CD141 / THBD Mouse IgG2a QBEND/40 Hu C, F, P
100 reaction / €900.00
  Abnova Taiwan Corp.

CD141 / THBD antibody

Western blot analysis of CD141 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CD141 / THBD antibody

Western blot analysis of CD141 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD141 / THBD antibody

Western blot analysis of CD141 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD141 / THBD antibody

CD141 - Human lymph node. Formalin fixed, paraffin processed tissue. Mouse IgG2a QBEND/40 Supernatant Hu, Rb C, F, P
0.1 ml / €340.00
  Novus Biologicals Inc.

CD141 / THBD antibody

CD141 / THBD Rat IgG2a RTM96 Purified Hu F, WB
50 µg / €400.00
  Novus Biologicals Inc.

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