CD153 / CD30L antibody

Principal name

CD153 / CD30L antibody

Alternative names for CD153 / CD30L antibody

TNFSF8, CD30 Ligand, CD30LG, CD30-L, Tumor necrosis factor ligand superfamily member 8

SwissProt ID

P32971 (Human), P32972 (Mouse)

Gene ID

21949 (Tnfsf8), 944 (TNFSF8)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit

Available applications

Flow Cytometry (F), Functional assay (FN), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of CD153 / CD30L antibody

The type-II membrane-associated glycoprotein CD30 ligand (CD30L) is a protein belonging to the TNF superfamily. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. The protein is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-KappaB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkins’s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling.

General readings

Smith C.A., et al (1993). Armitage R.J. Cell 73:1349-1360Croager E.J., et al (1997). Biochim. Biophys. Acta 1353:231-235

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