CD157 / BST1 antibody

Principal name

CD157 / BST1 antibody

Alternative names for CD157 / BST1 antibody

cADPr hydrolase 2, BST-1, ADP-ribosyl cyclase 2, Cyclic ADP-ribose hydrolase 2, Bone marrow stromal antigen 1

SwissProt ID

Q10588 (Human), Q63072 (Rat), Q64277 (Mouse)

Gene ID

683 (BST1), 12182 (Bst1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Mky (Monkey)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), EPair for Elisa (EPair), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD157 / BST1 antibody

Bone marrow stromal cell antigen-1 is ADP-ribosyl cyclases 2 enzyme and is also known as CD157. BST1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth (1). BST1/CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. After stress or inflammation BST1 is releases in extracellular compartment. It is one of the key factors in regulation of innate immunity. BST1 is a pleiotropic ectoenzyme which belongs to the CD38 family. Bst1 has 33% amino acid sequence similarity with CD38. These molecules are involved in the metabolism of NAD(+), capable of consuming extracellular NAD(+). The BST1/CD157 gene is located synthenicaly on chromosome 4p15 alongwith CD38.
BST1 is expressed in stromal cells, human neutrophils, leukocytes and corneal cells. In eye it has different from CD38 profile of expression and is expressed by basal limbal clusters, a p63(+)/cytokeratin 19(+) cell subset reported to contain corneal stem cells, and by stromal cells. BST1 expression is increased in rheumatoid arthritis cell line (2). This BST1 overexpession in stromal cells may lead to polyclonal B-cell abnormalities in rheumatoid arthritis patients. BST1 is expressed as a 42- to 45-kDa doublet. It is physically interacts with CD11b/CD18 complex in human neutrophils. Its function is described as NAD+ nucleosidase activity and hydrolase activity. It involved in process of humoral immune response, metabolic process and multicellular organismal development (6). Crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgamma-S, ethenoNADP, and ethenoNAD has been deduced (5). The BST1 expression is decreased and was deficient in paroxysmal nocturnal hemoglobinemia; crucial to regulation of innate immunity during inflammation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD157 / BST1 antibody

Western blot analysis of extracts from Jurkat cells and COS cells, using BST1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD157 / BST1 antibody

Flow cytometric analysis of BST-1 (CD157) expressionon U937 cells (white: isotypecontrol; grey: AM26424FC-N). Mouse IgG1 RF3 FITC Hu F
50 Tests / €360.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

Flow cytometric analysis of CD157 expression on U937. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26424PU-N to the cells. Mouse IgG1 RF3 Purified Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

Flow cytometric analysis of BST-1 expression on Lymphocyte (1), Monocyte (2) and Granulocyte (3). Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26424RP-N to the cells. Mouse IgG1 RF3 PE Hu F
50 Tests / €360.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) APC. Mouse IgG1 SY11B5 APC Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) APC. Mouse IgG1 SY11B5 Purified Hu, Prim C, F, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) APC. Mouse IgG1 SY11B5 PE Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

CD157 / BST1 Rat IgG2c KT157 Purified Ms F
0.25 mg / €380.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

CD157 / BST1 Rabbit Aff - Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD157 / BST1 antibody

CD157 / BST1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD157 / BST1 antibody

Western Blot analysis of BST1 expression in transfected 293T cell line (H00000683-T01) by BST1 MaxPab polyclonal antibody.

Lane 1: BST1 transfected lysate(35.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD157 / BST1 antibody

CD157 / BST1 Mouse IgG2a 4C2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD157 / BST1 antibody

Western blot analysis of extracts from COS7/Jurkat cells, using BST1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

CD157 / BST1 antibody

Western blot analysis of extracts from COS7/Jurkat cells, using BST1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

CD157 / BST1 antibody

Human COLO205; WB Suggested Anti-BST1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: COLO205 Whole Cell; BST1 antibody - middle region (ARP61591_P050) in Human COLO205 cells using Western Blot Rabbit Aff - Purified Hu
50 µg / €350.00
  AVIVA Systems Biology

CD157 / BST1 antibody

Immunofluorescent analysis of CD157 staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4  C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Hu, Mky, Ms, Rt ICC/IF, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CD157 / BST1 antibody

Immunofluorescent analysis of CD157 staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4  C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD157 / BST1 antibody

Immunofluorescent analysis of CD157 staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4  C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Hu, Mky, Ms, Rt ICC/IF, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD157 / BST1 antibody

CD157 / BST1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CD157 / BST1 antibody

CD157 / BST1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.

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