CD16 antibody

Principal name

CD16 antibody

Alternative names for CD16 antibody

FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A

SwissProt ID

P08508 (Mouse), P08637 (Human), Q28942 (Pig)

Gene ID

2214 (FCGR3A)

Available reactivities

Hu (Human), Prim (Primate), Por (Porcine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Functional assay (FN), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD16 antibody

The eBioCB16 monoclol antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, -1 and -2. Individuals homozygous for -2 show a lower phagocytic capacity compared with -1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate sigl transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

General readings

1. Schmidt, R.E. (1993) CD16 cluster workshop report. In Leucocyte Typing V: White cell differentiation antigens, Vol.1. Edited by Schlossman, S.F. et al. Oxford University Press. p805-806.
2. Zhu X, Hamann KJ, Muñoz NM, Rubio N, Mayer D, Hernrreiter A, et al. Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils. J Immunol. 1998 Sep 1;161(5):2574-9. PubMed PMID: 9725258.
3. Kakko, T. et al. (2011) Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Diab Vasc Dis Res. 8: 221-8.
4. Shantsila, E. et al. (2012) Fibrinolytic status in acute coronary syndromes: evidence of differences in relation to clinical features and pathophysiological pathways. Thromb Haemost. 108: 32-40.
5. Shantsila, E. et al. (2011) Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J Thromb Haemost. 9: 1056-66.
6. Tapp, L.D. et al. (2012) The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J Thromb Haemost. 10: 1231-41.
7. Ambarus, C.A. et al. (2012) Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis. Arthritis Res Ther. 14: R74.
8. Ambarus, C.A. et al. (2012) Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods. 375: 196-206.
9. Ambarus, C.A. et al. (2012) Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10. PLoS One. 7: e35994.
10. Shantsila, E. et al. (2012) The effects of exercise and diurnal variation on monocyte subsets and monocyte-platelet aggregates. Eur J Clin Invest. 42: 832-9.
11. Chehadeh. W. et al. (2009) Antibody-mediated opsonization of red blood cells in parvovirus B19 infection. Virology. 390: 56-63.
12. Wrigley, B.J. et al. (2013) Increased formation of monocyte-platelet aggregates in ischemic heart failure. Circ Heart Fail. 6: 127-35.
13. Jaipersad, A.S. et al. (2014) Expression of monocyte subsets and angiogenic markers in relation to carotid plaque neovascularization in patients with pre-existing coronary artery disease and carotid stenosis. Ann Med. 11: 1-9.
14. Shantsila, E. et al. (2015) Free Light Chains in patients with acute coronary syndromes: Relationships to inflammation and renal function. Int J Cardiol. 185: 322-7.
15. Wrigley, B.J. et al. (2013) Increased formation of monocyte-platelet aggregates in ischemic heart failure. Circ Heart Fail. 6 (1): 127-35.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD16 antibody

CD16 Mouse IgG1 G7 FITC Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD16 antibody

Staining of porcine peripheral blood granulocytes with MOUSE ANTI PORCINE
CD16:RPE Mouse IgG1 G7 PE Por F
100 Tests / €410.00
  Acris Antibodies GmbH

CD16 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD16 antibody (AM01321PU-T) Mouse IgG1 DJ130c Purified Hu C, F, P
0.2 mg / €480.00
  Acris Antibodies GmbH

CD16 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD16 antibody (AM01321PU-T) Mouse IgG1 DJ130c Purified Hu C, F, P
25 µg / €180.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD16 antibody

  Rabbit Monoclonal anti-CD16a Antibody  
Human lung stained with anti-CD16a antibody. Rabbit IgG SP175 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD16 antibody

  Rabbit Monoclonal anti-CD16a Antibody  
Western Blot analysis of K562 cell lysate with anti-CD16a antibody. Rabbit IgG SP189 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD16 antibody

  Mouse Anti-Human CD16 Purified (100 ug)  
Staining of normal human peripheral blood cells with 0.25 ug of  Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD16 Purified (filled histogram) followed by Anti-Mouse IgG FITC and granulocyte (right) gates were used for analysis. Mouse eBioCB16 (CB16) Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD16 antibody

  Rabbit Polyclonal Anti-FCGR3A Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (FCGR3A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD16 antibody

CD16 Mouse IgG1 DJ130c Biotin Hu F
0.1 mg / €440.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 DJ130c Biotin Hu F
25 µg / €210.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 DJ130c PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD16 antibody

Surface staining of lysed and washed porcine peripheral blood with purified anti-CD16 (MEM-168) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (AM03111PU-N). Panel B, C, D - three different porcine PMBC samples stained with anti-CD16 (MEM-168). Cells in the granulocyte gate were used for analysis. Mouse IgM MEM-168 Purified Hu F
0.1 mg / €210.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 Purified Hu F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 Biotin Hu F
100 Tests / €280.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 FITC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 Purified Hu C, F, IP, WB
0.1 mg / €190.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 PE Hu F
100 Tests / €320.00
  Acris Antibodies GmbH

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