CD16 antibody

Principal name

CD16 antibody

Alternative names for CD16 antibody

FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A

SwissProt ID

P08508 (Mouse), P08637 (Human), Q28942 (Pig)

Gene ID

2214 (FCGR3A), 397684 (FCGR3B), 14131 (Fcgr3)

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Functional assay (FN), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of CD16 antibody

The lymphocyte Fc gamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fc gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying Fc gamma R+ cells, monoclonal antibodies to the Fc gamma II/III receptor have been used to block Fc receptor binding of IgG, Fc mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc gamma R for parasitic invasion.

General readings

1,. Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
2. Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
3. Zhu X, Hamann KJ, Muñoz NM, Rubio N, Mayer D, Herrnreiter A, Leff AR: Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils. J Immunol. 1998 Sep 1;161(5):2574-9.
4. Metes D, Ernst LK, Chambers WH, Sulica A, Herberman RB, Morel PA: Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. Blood. 1998 Apr 1;91(7):2369-80.
5. Wijngaarden S, van Roon JA, van de Winkel JG, Bijlsma JW, Lafeber FP: Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment.
6. Komano Y, Nanki T, Hayashida K, Taniguchi K, Miyasaka N: Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. Arthritis Res Ther. 2006;8(5):R152.
7. Choi EI, Wang R, Peterson L, Letvin NL, Reimann KA: Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology. 2008 Jun;124(2):215-22. Epub 2008 Jan 12.
8. Congy-Jolivet N, Bolzec A, Ternant D, Ohresser M, Watier H, Thibault G: Fc gamma RIIIa expression is not increased on natural killer cells expressing the Fc gamma RIIIa-158V allotype. Cancer Res. 2008 Feb 15;68(4):976-80.
9. Burt BM, Plitas G, Zhao Z, Bamboat ZM, Nguyen HM, Dupont B, DeMatteo RP: The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors. J Immunol. 2009 Aug 1;183(3):1789-96.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD16 antibody

CD16 Mouse IgG1 G7 FITC Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD16 antibody

Staining of porcine peripheral blood granulocytes with MOUSE ANTI PORCINE
CD16:RPE Mouse IgG1 G7 PE Por F
100 Tests / €410.00
  Acris Antibodies GmbH

CD16 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD16 antibody (AM01321PU-T) Mouse IgG1 DJ130c Purified Hu C, F, P
0.2 mg / €480.00
  Acris Antibodies GmbH

CD16 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD16 antibody (AM01321PU-T) Mouse IgG1 DJ130c Purified Hu C, F, P
25 µg / €180.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD16 antibody

Staining of normal human peripheral blood cells with 0.25 ug of  Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD16 Purified (filled histogram) followed by Anti-Mouse IgG FITC and granulocyte (right) gates were used for analysis. Mouse eBioCB16 (CB16) Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD16 antibody

CD16 Mouse IgG1 DJ130c Biotin Hu F
0.1 mg / €440.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 DJ130c Biotin Hu F
25 µg / €210.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 DJ130c PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD16 antibody

Surface staining of lysed and washed porcine peripheral blood with purified anti-CD16 (MEM-168) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (AM03111PU-N). Panel B, C, D - three different porcine PMBC samples stained with anti-CD16 (MEM-168). Cells in the granulocyte gate were used for analysis. Mouse IgM MEM-168 Purified Hu F
0.1 mg / €210.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG1 J5511 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 Biotin Hu F
100 Tests / €280.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 FITC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 Purified Hu C, F, IP, WB
0.1 mg / €190.00
  Acris Antibodies GmbH

CD16 antibody

CD16 Mouse IgG2a GRM1 PE Hu F
100 Tests / €320.00
  Acris Antibodies GmbH

CD16 antibody

Human placenta, staining with AM26063PU-N  in Immunohistochemistry on frozen sections. Mouse IgG1 c127 Aff - Purified Hu C, F, IP
0.2 mg / €280.00
  Acris Antibodies GmbH

CD16 antibody

A typical staining pattern with the B-E16 monoclonal antibody of lymphocytes Mouse IgG2a B-E16 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD16 antibody

A typical staining pattern with the B-E16 monoclonal antibody of lymphocytes Mouse IgG2a B-E16 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

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