CD161 / KLRB1 antibody

Principal name

CD161 / KLRB1 antibody

Alternative names for CD161 / KLRB1 antibody

HNKR-P1a, CLEC5B, NKRP1A, Killer cell lectin-like receptor subfamily B member 1, Natural killer cell surface protein P1A, C-type lectin domain family 5 member B

SwissProt ID

P27471 (Rat), P27811 (Mouse), Q12918 (Human)

Gene ID

3820 (KLRB1), 362443 (Klrb1a), 17057

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

Functional assay (FN), Western blot / Immunoblot (WB), Flow Cytometry (F), Cytotoxicity Assay (CT), Immunoprecipitation (IP), Frozen Sections (C), Radioimmunoassay (R), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CD161 / KLRB1 antibody

CD161 is a C-Type Lectin Receptor, also known as NKR-P1A, previously found on NKT cells and subsets of T-cells(1). Phenotyping of cells that are functionally producing IL-17 has shown the one constant marker is CD161. While it had been shown previously that human CD4+ cells that produce both IL-17 and IFNg give rise to Th17/Th1 cells, indicating common etiology of these two T cell subsets (2-4), a clear marker for cells producing IL-17 is CD161. In fact, all cells characterized as the following subsets CD4+TCRab+, CD8+TCRab+, CD4-CD8-TCRab+, and CD4-CD8-TCRgd+ bearing CD161 also produce IL-17 but cells of these same phenotypes and functional marker which do not bear CD161 also do not produce IL-17(7). Induction of CD161 expression by transduction with RORC also induces IL-1R and IL-23R as well as the ability to produce IL-17(4). The ability to produce IL-17 and the induction of CD161 shows a strong dependency for RORC(4). Antibody to CD161 provides a probe for identifying IL-17 producing cells and offers a finer delineation of additional subsets derived from Th17 and their functional characteristics through cytokine mRNA expression or production.

General readings

Clone HP-3G10 is used in these references:
1. Pozo, D., et al., J. Immunol. 176, 2397-2406 (2006)
2. Rosen, D. B., et al., J. Immunol. 175, 7796-7799 (2005)
3. Gumá, M., et al., Blood 104, 3664-3671 (2004)
4. Le, P. T., et al., J. Immunol. 166, 2194-2201 (2001)
5. Exley, M., et al., J. Exp. Med. 188, 867-876 (1998)
6. Márquez, C., et al., Blood 91, 2760-2771 (1998)
7. Ida, H., et al., Leukocyte Typing VI, 313-317 (1997)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD161 / KLRB1 antibody

Western Blot: CD161 Antibody (14F1F11) [TA336907] - Western blot analysis of a partial CD161 recombinant protein using CD161 antibody at 1 ug/ml. Mouse IgG1 14F1F11 Purified Hu C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD161 / KLRB1 antibody

Figure 1. Flow cytometric analysis of CD161 expression on peripheral blood lymphocytes: Open Histogram indicates the reaction of isotypic control to the lymphocytes. Shaded Histogram indicates the reaction of C161 antibody (AM20021AF-N) to the lymphocytes. Mouse IgG1 HP-3G10 Azide Free Hu F
0.1 mg / €360.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

Figure 1. Flow cytometric analysis of CD161 expression on human peripheral blood lymphocytes: Open histogram indicates the reaction of isotypic control to the cells. Shaded Histogram indicates the reaction of CD161 antibody (AM20021FC-N) to the cells. Mouse IgG1 HP-3G10 FITC Hu F
1 ml (50 Tests) / €350.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 HP-3G10 Purified Hu, Prim F, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 HP-3G10 PE Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

A typical staining pattern of lymphocytes with the B-D51 monoclonal antibody Mouse IgG1 B-D51 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG2a PK136 Azide Free Ms F, FN, WB
1 mg / €790.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG2a PK136 Biotin Ms F
25 µg / €180.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG2a PK136 Purified Ms CT, F, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG2a PK136 Purified Ms CT, F, IP
25 µg / €170.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

Staining of New Zealand Black mouse peripheral blood lymphocytes with Mouse anti Mouse NK cells - RPE (SM067R/RT) Mouse IgG2a PK136 PE Ms F
100 Tests / €290.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

Staining of New Zealand Black mouse peripheral blood lymphocytes with Mouse anti Mouse NK cells - RPE (SM067R/RT) Mouse IgG2a PK136 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 Azide Free Rt C, F, FN, IP, R, WB
1 mg / €810.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 FITC Rt F
0.1 mg / €470.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 FITC Rt F
50 µg / €320.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 FITC Rt F
0.5 mg / €650.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 Purified Rt C, F, IP, R, WB
0.25 mg / €420.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG1 10/78 Purified Rt C, F, IP
0.1 mg / €260.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

SM293R (MOUSE ANTI RAT CD161:RPE) staining of rat splenocytes. Mouse IgG1 10/78 PE Rt F
100 Tests / €530.00
  Acris Antibodies GmbH

CD161 / KLRB1 antibody

CD161 / KLRB1 Mouse IgG2b B199.2 FITC Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

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