CD169 / SIGLEC1 antibody

Principal name

CD169 / SIGLEC1 antibody

Alternative names for CD169 / SIGLEC1 antibody

Sialoadhesin, Siglec-1, Sialic acid-binding Ig-like lectin 1

SwissProt ID

A7LCJ3 (Pig), D3ZVM6 (Rat), Q62230 (Mouse), Q9BZZ2 (Human)

Gene ID

20612 (Siglec1), 6614 (SIGLEC1), 397623

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Por (Porcine)

Available hosts

Rat, Mouse, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P), Radioimmunoassay (R), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Functional assay (FN), Western blot / Immunoblot (WB)

Background of CD169 / SIGLEC1 antibody

The sialoadhesin family has 4 members: CD22, a B cell specific marker; myelin associated glycoprotein (MAG), which is expressed on oligodendrocytes and Schwann cells; CD33, a myeloid differentiation antigen; and sialoadhesin, which is expressed only by a subpopulation of tissue macrophages. Involved in cell-cell interactions, sialoadhesin is structurally related to the 3 other listed members of the sialoadhesin family. CD169 is a sialic acid binding site of sialoadhesin. CD169 is a macrophage receptor expressed on stromal macrophages in many tissues, particularly found in lymph nodes, bone marrow and spleen. 
Metallophilic macrophages are a subpopulation of mature resident tissue macrophages. They show high non specific esterase activity and can be distinguished from splenic marginal zone macrophages by antibody staining and the lack of FITC-Ficoll uptake.

General readings

1. Crocker, P.R. et al. (1991) Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. EMBO J. 10: 1661-1669.
3. Barral, P. et al. (2010) CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. Nat Immunol. 11: 303-12.
4. Chtanova, T. et al. (2008) Dynamics of neutrophil migration in lymph nodes during infection. Immunity. 29: 487-96.
5. Hsu, K.M. et al. (2009) Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J Gen Virol. 90:33-43.
6. Iannacone M (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 465: 1079-83.
7. Idoyaga, J. et al. (2009) Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 106: 1524-9.
8. Kaisho, T. et al. (2001) IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med. 193: 417-26.
8. Taylor, P.R. et al. (2008) Development of a specific system for targeting protein to metallophilic macrophages. Proc Natl Acad Sci U S A. 101: 1963-8.
9. Kang, Y.S. et al. (2004) The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 101: 215-20.
10. Lin, H.H. et al. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 201: 1615-25.
11. Phillips, R. et al. (2010) Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7. PLoS Pathog. 6(3):e1000813.
12. Hashimoto, D. et al. (2011) Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med. 208: 1069-82.
13. Anderson, K.L. et al. (1999) PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood. 94: 2310-8.
14. Albacker, L.A. et al. (2010) TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 185: 6839-49.
15. Anthony, R.M. et al. (2008) Identification of a receptor required for the anti-inflammatory activity of IVIG. Proc Natl Acad Sci U S A. 105: 19571-8.
16. Chow, A. et al. (2011) Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med. 208: 261-71.
17. Hemmi, H. et al. (2009) A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. J Immunol. 182: 1278-86.
18. Hemmi, H. et al. (2012) Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
J Immunol. 188: 1147-55.
19. Huang, Q.Q. et al. (2010) FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood. 116: 4968-77.
20. Lu, M. and Munford, R.S. (2011) The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potencyin vivo.
J Immunol. 187: 3314-20.
21. Mansour, A. et al. (2012) Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.
J Exp Med. 209: 537-49.
22. Vagaja, N.N. et al. (2012) Changes in murine hyalocytes are valuable early indicators of ocular disease.
Invest Ophthalmol Vis Sci. 53: 1445-51.
23. Barnes, Y.C. et al. (1999) Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion.
Blood. 93: 1245-52.
24. Chen, W.C. et al. (2012) Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169.
PLoS One. 7e39039.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD169 / SIGLEC1 antibody

Immunohistochemistry: SM066B Metallophilic Macrophages antibody staining of Mouse Spleen Frozen Section. Rat IgG2a MOMA-1 Biotin Ms C
0.2 mg / €530.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

Staining of mouse spleen using MOMA-1 Cat. SM066P. Note the typical staining of metallophilic macrophages in the marginal zone. Rat IgG2a MOMA-1 Purified Ms C, F
0.2 mg / €480.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Rat IgG2a MOMA-1 Supernatant Ms C, F, ICC/IF
2 ml / €510.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

SM066F CD169 antibody staining of Mouse spleen. Rat IgG2a MOMA-1 FITC Ms F, ICC/IF
0.1 mg / €470.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 Low Endotoxin Hu C, F, FN, IP
0.5 mg / €540.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 Purified Hu C, F, IP
0.2 mg / €480.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 Purified Hu C, F, IP
0.1 mg / €280.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 Purified Hu C, F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 PE Hu F
100 Tests / €470.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 7-239 PE Hu F
25 Tests / €210.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 3B1/11 FITC Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG1 3B1/11 Purified Por C, F, IP, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

Mouse Peritoneal Macrophages stained with Rat anti Mouse CD169 Antibody -FITC Cat.-No AM05902FC-N (Clone 3D6.112) Rat IgG2a 3D6.112 FITC Ms F
0.1 mg / €570.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

Mouse Peritoneal Macrophages stained with Rat anti Mouse CD169 Antibody -FITC Cat.-No AM05902FC-N (Clone 3D6.112) Rat IgG2a 3D6.112 FITC Ms F
25 µg / €270.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Rat IgG2a 3D6.112 Low Endotoxin Ms C, F, ICC/IF
0.5 mg / €670.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

Frozen Mouse spleen stained with Rat anti Mouse CD169 Antibody Cat.-No AM05902PU-N (Clone 3D6.112) Rat IgG2a 3D6.112 Purified Ms C, F, ICC/IF
0.2 mg / €490.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

Frozen Mouse spleen stained with Rat anti Mouse CD169 Antibody Cat.-No AM05902PU-N (Clone 3D6.112) Rat IgG2a 3D6.112 Purified Ms C, F, ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

CD169 / SIGLEC1 antibody

CD169 /  SIGLEC1 Mouse IgG2a ED3 Purified Rt C, F, ICC/IF, IP

Regular Price: 0.25 mg / €510.00

Special Price: 0.25 mg / €315.00

  Acris Antibodies GmbH

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