CD171 / L1CAM antibody

Principal name

CD171 / L1CAM antibody

Alternative names for CD171 / L1CAM antibody

N-CAM L1, CAML1, MIC5, Neural cell adhesion molecule L1

SwissProt ID

P11627 (Mouse), P32004 (Human), Q05695 (Rat)

Gene ID

3897 (L1CAM)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine), Chk (Chicken), Mam (Mammalia)

Available hosts

Goat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP)

Background of CD171 / L1CAM antibody

L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers. L1CAM has also been designated CD171 (cluster of differentiation 171).The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. CD171 has been shown to function as a cell adhesion molecule mediating homotypic and heterotypic cell-cell interactions in neuronal myelination, neurite outgrowth and regeneration. Expression of CD171 is found on tetanus-toxin positive neurons, endothelial cells, certain epithelial cells, reticular fibroblasts and several malignant tumors including colon and breast carcinomas, colon melanoma, tumor cells of neuronal and mesothelial origin, where a role of CD171 in augmenting tumor growth has been demonstrated. Thus, CD171 is considered a novel marker for carcinoma progression.CD171 displays binding to a number of ligands including homophilic interaction with itself and heterophilic binding to integrins, other cell adhesion molecules, extracellular matrix molecules and thus plays a vital role in cell adhesion and signal transduction. It is involved in the development of the nervous system and regulates processes such as neuron-neuron adhesion, myelination, axonal guidance, and neuronal migration.

General readings

Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480 (2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010)
Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010)
Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437 (2010)
Gavert, N., et al. J. Cell. Sci. 123 (PT 12), 2135-2143 (2010)

  1. Quick-Filters:
  2. Highly Validated (17)

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone UMAB47  
Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500043; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB47 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone UMAB48  
Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500044; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB48 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone UMAB47  
Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500043; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB47 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone UMAB48  
Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500044; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB48 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI10C12 (formerly 10C12)  
Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500334) Mouse IgG1 OTI10C12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI1H3 (formerly 1H3)  
CD171 / L1CAM Mouse IgG1 OTI1H3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  anti-L1CAM mouse monoclonal antibody, clone OTI2A6 (formerly 2A6)  
Immunohistochemical staining of paraffin-embedded endometrium tissue within the normal limits using anti-L1CAMmouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500728, Dilution 1:50) Mouse IgG1 OTI2A6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2C7 (formerly 2C7)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500729) Mouse IgG1 OTI2C7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2H5 (formerly 2H5)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500732) Mouse IgG1 OTI2H5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI3G1 (formerly 3G1)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500792) Mouse IgG1 OTI3G1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI4F4 (formerly 4F4)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500800) Mouse IgG1 OTI4F4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2A11 (formerly 2A11)  
Anti-L1CAM mouse monoclonal antibody (TA501436) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY L1CAM(RC211601). Mouse IgG1 OTI2A11 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI1A8 (formerly 1A8)  
Anti-L1CAM mouse monoclonal antibody (TA501437) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY L1CAM(RC211601). Mouse IgG2a OTI1A8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2A5 (formerly 2A5)  
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-L1CAM monoclonal antibody. Mouse IgG1 OTI2A5 Purified Hu, Mky F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  anti-L1CAM mouse monoclonal antibody, clone OTI2G9 (formerly 2G9)  
Anti-L1CAM mouse monoclonal antibody (TA501441) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY L1CAM(RC211601). Mouse IgG1 OTI2G9 Purified Can, Hu, Mky F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2B11 (formerly 2B11)  
Anti-L1CAM mouse monoclonal antibody (TA501464) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY L1CAM(RC211601). Mouse IgG1 OTI2B11 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  L1CAM mouse monoclonal antibody, clone OTI2H6 (formerly 2H6)  
Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-L1CAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501496) Mouse IgG1 OTI2H6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD171 / L1CAM antibody

  Mouse Anti-Human CD171 Purified (25 ug)  
Staining of Panc-1 cell line with 0.125 ug of Mouse IgG2a kappa Isotype Control Purified (open histogram) or 0.125 ug of Anti-Human CD171 Purified (filled histogram).  Total viable cells were used for analysis. Mouse eBio5G3 (5G3) Purified Hu F, IP, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

CD171 / L1CAM antibody

  Rabbit Polyclonal Anti-L1CAM Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (L1CAM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD171 / L1CAM antibody

  Mouse Monoclonal anti-CD171 (L1) Antibody  
Staining of L1 (CD171), clone 14.10, on formalin fixed paraffin embedded normal human colon tissue. Mouse IgG1 14.10 Purified P
1 ml / €679.00
  OriGene Technologies, Inc.

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn