CD18 / ITGB2 antibody

Principal name

CD18 / ITGB2 antibody

Alternative names for CD18 / ITGB2 antibody

Integrin beta-2, MFI7, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta

SwissProt ID

P05107 (Human), P11835 (Mouse), P32592 (Bovin), P53714 (Pig), Q09062 (Xenla), Q6ECI6 (Sheep), Q9JI30 (Rat)

Gene ID

3689 (ITGB2), 16414 (Itgb2), 25021 (Itgam), 281877, 396943

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rat, Rabbit, Hamster, Goat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Functional assay (FN), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of CD18 / ITGB2 antibody

In the immune system, integrins have essential roles in leukocyte trafficking and function. These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues (1). Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial for integrin-mediated signaling. JAB1 (Jun activation domain-binding protein 1), a coactivator of the c-Jun transcription factor, has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections (3)

General readings

This product has been used in:Drbal K et al. A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. Blood 98:1561-6 (2001). PubMed PMID: 11520808
Drbal K et al. A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins. Immunobiology 203:687-98 (2001). PubMed PMID: 11402502
Drbal K et al. Human leukocytes contain a large pool of free forms of CD18. Biochem Biophys Res Commun 275:295-9 (2000). PubMed PMID: 10964661

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD18 / ITGB2 antibody

Staining of mouse splenocytes with Anti-Mouse CD18 PE.  Autofluorescence is shown via open histogram.  Total viable cells were used for analysis. Rat M18/2 Purified Ms F, IP, P, WB
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD18 / ITGB2 antibody

Western blot analysis of extracts of THP-1 cell lines, using ITGB2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD18 / ITGB2 (86-99) antibody

TA334177 (0.3µg/ml) staining of K562 (A) and U937 (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 Bu86 FITC Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 Bu86 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 Bu86 Purified Hu F
0.2 mg / €430.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 PNK-I FITC Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

Staining of porcine eripheral blood granulocytes with MOUSE ANTI PORCINE CD18a Mouse IgG1 PNK-I Purified Por F, IP
0.2 mg / €530.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 PNK-I PE Por F
100 Tests / €330.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 3EB Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

Figure 1. Peripheral Blood Lymphocytes Stained with AM05179FC-N antibody. Mouse IgG1 3EB FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 3EB Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Mouse IgG1 3EB PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Rat IgG2a M18/2 FITC Ms F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Rat IgG2a M18/2 Purified Ms F, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Rat IgG2a M18/2 Purified Ms F, IP
0.1 mg / €230.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

CD18 / ITGB2 Rat IgG2a M18/2 Purified Ms F, IP
25 µg / €170.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

Confocal immunofluorescence analysis of HL60 cells using CD18 antibody Cat.-No AM06337SU-N (green). Blue: DRAQ5 fluorescent DNA dye. Mouse IgG2b 10E12 Ascites Hu, Ms E, ICC/IF
0.1 ml / €400.00
  Acris Antibodies GmbH

CD18 / ITGB2 antibody

AM08244AF-N CD18 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen. Mouse IgG1 MEM-48 Azide Free Hu C, F, FN, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD18 / ITGB2 (N-term) antibody

IHC staining with Integrin β2 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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