CD180 / RP105 antibody

Principal name

CD180 / RP105 antibody

Alternative names for CD180 / RP105 antibody

LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein

SwissProt ID

Q62192 (Mouse), Q99467 (Human)

Gene ID

4064 (CD180), 17079 (Cd180)

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey)

Available hosts

Rat, Mouse, Rabbit

Available applications

Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), Functional assay (FN)

Background of CD180 / RP105 antibody

The MHR73-11 monoclol antibody reacts with human CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germil center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and sigling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and D synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a sigl transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD180 / RP105 (C-term) antibody

  Rabbit Polyclonal RP105 Antibody  
Western blot analysis of RP105 in human spleen tissue lysate with RP105 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD180 / RP105 (N-term) antibody

  Rabbit Polyclonal RP105 Antibody  
Western blot analysis of RP105 in human spleen tissue lysate with RP105 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD180 / RP105 antibody

  Rabbit Polyclonal RP105 Antibody  
Western blot analysis of RP105 in human spleen tissue lysate with RP105 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD180 / RP105 antibody

  Mouse Anti-Human CD180 (RP105) Purified (25 ug)  
Staining of normal human peripheral blood cells with 1 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 1 ug of Anti-Human CD180 (RP105) Purified (filled histogram) followed by Anti-Mouse IgG FITC .  Cells in the lymphocyte gate were used for analysis. Mouse MHR73-11 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

CD180 / RP105 antibody

  Rat Anti-Mouse CD180 (RP105) Purified (50 ug)  
Surface staining of mouse splenocytes with Anti-Mouse CD180 (RP105) PE.  Appropriate isotype controls were used  (open histogram).  Total viable cells were used for analysis. Rat RP/14 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD180 / RP105 antibody

  Mouse Monoclonal anti-CD180 (RP105) Antibody  
Human peripheral blood lymphocytes stained with purified MHR73-11, followed by anti-mouse IgG FITC Mouse MHR73-11 Purified Hu F, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD180 / RP105 antibody

CD180 / RP105 Mouse IgG1 G28-8 Low Endotoxin Hu F, FN, IP
0.1 mg / €210.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Mouse IgG1 G28-8 Aff - Purified Hu F, FN, IP
0.1 mg / €250.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Mouse IgG1 MHR73 Biotin Hu C
50 µg / €290.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Mouse IgG1 MHR73 FITC Hu C, FN, IP
0.1 mg / €400.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Mouse IgG1 MHR73 Purified Hu C, FN, IP, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Rat IgG2a RP/14 Biotin Ms F
50 µg / €290.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Rat IgG2a RP/14 FITC Ms F
0.1 mg / €400.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Rat IgG2a RP/14 Purified Ms F
0.25 mg / €510.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Rat IgG2a RP/14 Purified Ms F, FN
0.1 mg / €350.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

CD180 / RP105 Rat IgG2a RP/14 Purified Ms
25 µg / €190.00
  Acris Antibodies GmbH

CD180 / RP105 antibody

Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD180: FITC (SM1824F). Mouse IgG1 MHR73-11 FITC Hu F
0.1 mg / €490.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CD180 - human gene knockout kit via CRISPR

CD180 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CD180 - human gene knockout kit via CRISPR

CD180 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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