CD181 / IL8RA antibody

Principal name

CD181 / IL8RA antibody

Alternative names for CD181 / IL8RA antibody

IL-8R A, IL-8 receptor type 1, CXCR-1, CXCR1, CMKAR1, CDw128a, IL8 receptor alpha, High affinity interleukin-8 receptor A

SwissProt ID

P25024 (Human), P70612 (Rat), Q810W6 (Mouse)

Gene ID

3577 (CXCR1), 227288 (Cxcr1), 54258

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Mky (Monkey), Gorilla

Available hosts

Mouse, Rabbit, Goat

Available applications

Flow Cytometry (F), Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of CD181 / IL8RA antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the superfamily of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2).
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CXCR have been characterized (Table1).
CXCR1 has been implicated in IL8 induced chemotaxis of melanoma cells. The nonresponsive WM35 melanoma cells when stimulated by TNFexpress higher levels of CXCR1 and exhibit chemotactic towards interleukin-8 (3). Stimulation of CXCR1 also induce focal adhesion kinase (FAK) phosphorylation, that regulate the chemotactic activities of the migrating cells (4). On the contrary, glucocorticoid/dexamethasone has potent anti-inflammatory effects, yet it up-regulates expression of CXCR4 but not that of CXCR1 and CXCR3 (4).
The CXCR receptor protein is approximately 45-55 kDa (405 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The all CXCR sequence analyses suggest the presence of 7 transmembrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CXCR-selective antibodies were generated against conserved but unique sequences on various CXCR receptors that are expressed only in a particular CXCR receptor subtype.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD181 / IL8RA (N-term) antibody

  CXCR1 Rabbit Polyclonal (N-Terminus) Antibody  
Anti-CXCR1 antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  CXCR1 Rabbit Polyclonal (Internal) Antibody  
Anti-CXCR1 antibody IHC of human colon, plasma cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  CXCR1 Rabbit Polyclonal (C-Terminus) Antibody  
Anti-CXCR1 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 16 ug/ml. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  Mouse Anti-Human CD181 (CXCR1) Purified (100 ug)  
Staining of normal human peripheral blood cells with 0.25 ug of Mouse IgG2b kappa Isotype Control Purified (left) or 0.25 ug of Anti-Human CD181 (CXCR1) Purified (right) followed by F(ab')2 Anti-Mouse IgG PE .  Cells in the large scatter population were used for analysis. Mouse eBio8F1-1-4 (8F1-1-4) Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  Rabbit Polyclonal Anti-CXCR1 (extracellular)  
Western blot analysis of CXCR1 in Jurkat cell lysate: 1. Anti-CXCR1 (extracellular) antibody, (1:200). 2. Anti- CXCR1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  Goat Anti-CXCR1 (aa26-38) Antibody  
TA334182 (0.3µg/ml) staining of Human Breast cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

  Rabbit Polyclonal Anti-CXCR1 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Human colon cancer tissue, Human placenta tissue, Primary antibody: (CXCR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD181 / IL8RA antibody

(Left Panel) Typical staining observed with FAB330F on mouse cells transfected with the human CXCR1/IL-8 RA and CXCR2/IL-8 RB gene. An isotype control staining of the CXCR1 transfected cells is also shown.
(Right Panel) Typical staining observed with FC15001 on human peripheral granulocytes. An isotyFluorescein-matched conter staining of the same granulocytes is also shown. Mouse IgG2a 42704 FITC Hu, Rt F
100 Tests / €390.00
  Neuromics Antibodies

CD181 / IL8RA antibody

Indirect  immunofluorescent CXCR1/IL-8 RA  staining (red) of  human lymph nodes. Mouse IgG2a 42704 Purified Hu C, F
0.5 mg / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

CXCR1 - human gene knockout kit via CRISPR

CXCR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CXCR1 - human gene knockout kit via CRISPR

CXCR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXCR1 - human gene knockout kit via CRISPR

CXCR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXCR1 - human gene knockout kit via CRISPR

CXCR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxcr1 - mouse gene knockout kit via CRISPR

Cxcr1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxcr1 - mouse gene knockout kit via CRISPR

Cxcr1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CXCR1 overexpression lysate

CXCR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CXCR1 (mGFP-tagged) - Human chemokine (C-X-C motif) receptor 1 (CXCR1), 200 uL, >10^7 TU/mL

Lenti ORF particles, CXCR1 (mGFP-tagged) - Human chemokine (C-X-C motif) receptor 1 (CXCR1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CXCR1 (Myc-DDK tagged) - Human chemokine (C-X-C motif) receptor 1 (CXCR1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CXCR1 (Myc-DDK tagged) - Human chemokine (C-X-C motif) receptor 1 (CXCR1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cxcr1 (GFP-tagged) - Mouse chemokine (C-X-C motif) receptor 1 (Cxcr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxcr1 (GFP-tagged) - Mouse chemokine (C-X-C motif) receptor 1 (Cxcr1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cxcr1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) receptor 1 (Cxcr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxcr1 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) receptor 1 (Cxcr1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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