CD183 / CXCR3 antibody

Principal name

CD183 / CXCR3 antibody

Alternative names for CD183 / CXCR3 antibody

CXC-R3, CXCR-3, IP10 receptor, IP-10 receptor, GPR9, Interferon-inducible protein 10 receptor, G protein-coupled receptor 9

SwissProt ID

O88410 (Mouse), P49682 (Human), Q5MD61 (Bovin), Q9JII9 (Rat)

Gene ID

2833 (CXCR3), 12766 (Cxcr3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Gt (Goat), Mky (Monkey), Bear

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of CD183 / CXCR3 antibody

Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The alpha and beta families, with four cysteine residues, are the largest and best characterized. In the alpha family, one amino acid separates the first two cysteine residues (CXC); in the beta family the two cysteine residues (CC) are adjacent to each other. The alpha chemokines that contain the N-terminal Glu-Leu-Arg amino acid sequence (ELR-motif) are chemotactic for neutrophils (such as IL8), while those that do not, act on lymphocytes (such as IP10 and MIG). Examples of chemokines under the beta family category are MCP1-5 and RANTES. The chemokine lymphotactin belongs to the gamma family, with only two cysteines (C), and the recently described fractalkine or neurotactin is a member of the delta family and has the first two cysteine residues separated by three amino-acids (CXXXC). Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells. Receptor expression has also been found to be constitutive (including down regulation), inducible or restricted to a cell state of activation. In addition, some chemokine receptors are also expressed in non-hematopoietic cells, such as nerve, endothelial and epithelial cells. This suggests that chemokines have other roles besides leucocyte chemotaxis. CX3CR1, for example, is highly expressed in adult brain. Chemokine receptors are linked to phospholipases through the Gi class of G proteins (inhibition by pertussis toxin). Receptor activation leads to a cascade of cellular events including generation of inositol triphosphate, calcium release and activation of protein kinase C. Chemokine receptors also activate small GTP-binding proteins of the Ras and Rho families, the latter being involved in cell motility events. In addition, chemokines bind to non-signaling molecules such as the Duffy antigen receptor for chemokines (DARC) which may act to remove chemokines from the circulation, and heparan sulfates proteoglycans which may serve to establish an ECM concentration gradient.CXCR3, also known as the IP10/ Mig receptor, shares approximately 40% protein sequence identity with CXCR1 and CXCR2, and 34. 2 -36.9% amino acid sequence identity with the five known CC chemokine receptors 1-5. CXCR3 is highly expressed by IL2 activated T lymphocytes (Th1), but not by resting T lymphocytes, B lymphocytes, monocytes or granulocytes. CXCR3 binds IP10 and Mig (but not PF4) with high affinity and mediates Ca2+ mobilization and chemotaxis. CXCR3 does not bind any of the CXC chemokines containing the ELR motif.

General readings

Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). PubMed PMID: 9786026
Loetscher M et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 184:963-9 (1996). PubMed PMID: 9064356

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD183 / CXCR3 antibody

Western blot analysis of extracts from K562 cells, using CXCR3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321359(CXCR3 Antibody)(left image) at dilution 1/20, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using CXCR3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Predicted band size: 40kDa. Positive control: Mouse liver tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 40 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Western blot analysis of CXCR3 in HepG2 lysate with CXCR3 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Western blot analysis of extracts of various cell lines, using CXCR3 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

Western Blot: CXCR3 Antibody [TA336350] - 293T cells. Image from verified customer review. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 (C-term) antibody

Anti-CXCR3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Gt, Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

CD183 / CXCR3 Rabbit Biotin Hu C, Dot, E, IP, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

CD183 / CXCR3 (Center) antibody

CXCR3 Antibody (Center) (Cat. #AP51144PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CXCR3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD183 / CXCR3 antibody

CD183 / CXCR3 Mouse IgM 1C5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

CD183 / CXCR3 antibody

CD183 / CXCR3 Goat Hu, Ms, Rt E
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD183 / CXCR3 antibody

CD183 / CXCR3 Rabbit Ms, Rt C, IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CD183 / CXCR3 antibody

CD183 / CXCR3 Rabbit Hu C, IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CD183 / CXCR3 antibody

Western blot analysis of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

CD183 / CXCR3 antibody

Western blot analysis of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

CD183 / CXCR3 antibody

Immunohistochemical analysis of CD183 staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CD183 / CXCR3 antibody

Immunohistochemical analysis of CD183 staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD183 / CXCR3 antibody

Immunohistochemical analysis of CD183 staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD183 / CXCR3 antibody

CD183 / CXCR3 Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

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