CD183 / CXCR3 antibody

Principal name

CD183 / CXCR3 antibody

Alternative names for CD183 / CXCR3 antibody

CXC-R3, CXCR-3, IP10 receptor, IP-10 receptor, GPR9, Interferon-inducible protein 10 receptor, G protein-coupled receptor 9

SwissProt ID

O88410 (Mouse), P49682 (Human), Q5MD61 (Bovin), Q9JII9 (Rat)

Gene ID

2833 (CXCR3), 12766 (Cxcr3), 84475

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Gt (Goat), Mky (Monkey), Bear

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of CD183 / CXCR3 antibody

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

General readings

1. Gregorovic G  et al. Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines. J Virol 85:3535-45 (2011). WB ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD183 / CXCR3 antibody

  Rabbit polyclonal anti-CXCR3 antibody  
Western blot analysis of extracts from K562 cells, using CXCR3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

  Anti-CXCR3 Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321359(CXCR3 Antibody)(left image) at dilution 1/20, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

  Anti-CXCR3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human thyroid and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using CXCR3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

  Rabbit Polyclonal CXCR3 Antibody  
Western blot analysis of CXCR3 in HepG2 lysate with CXCR3 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

  Rabbit anti-CXCR3 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CXCR3 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 antibody

  Rabbit Polyclonal CXCR3 Antibody  
Western Blot: CXCR3 Antibody [TA336350] - 293T cells. Image from verified customer review. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD183 / CXCR3 (C-term) antibody

  Rabbit Polyclonal Anti-CXCR3 Antibody (C-Terminus)  
Anti-CXCR3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Gt, Hu, Mky P
50 µg / €400.00
  OriGene Technologies, Inc.

CD183 / CXCR3 (Center) antibody

CXCR3 Antibody (Center) (Cat. #AP51144PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CXCR3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD183 / CXCR3 antibody

Western blot analysis of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

CD183 / CXCR3 antibody

Western blot analysis of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CXCR3 - human gene knockout kit via CRISPR

CXCR3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXCR3 - human gene knockout kit via CRISPR

CXCR3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXCR3 - human gene knockout kit via CRISPR

CXCR3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxcr3 - mouse gene knockout kit via CRISPR

Cxcr3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cxcr3 - mouse gene knockout kit via CRISPR

Cxcr3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxcr3 - mouse gene knockout kit via CRISPR

Cxcr3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxcr3 - mouse gene knockout kit via CRISPR

Cxcr3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CXCR3 overexpression lysate

CXCR3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CXCR3 (mGFP-tagged)-Human chemokine (C-X-C motif) receptor 3 (CXCR3), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, CXCR3 (mGFP-tagged)-Human chemokine (C-X-C motif) receptor 3 (CXCR3), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €1,010.00
  OriGene Technologies, Inc.

Lenti ORF particles, CXCR3 (Myc-DDK-tagged)-Human chemokine (C-X-C motif) receptor 3 (CXCR3), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, CXCR3 (Myc-DDK-tagged)-Human chemokine (C-X-C motif) receptor 3 (CXCR3), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

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