CD184 / CXCR4 antibody

Principal name

CD184 / CXCR4 antibody

Alternative names for CD184 / CXCR4 antibody

CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR, C-X-C chemokine receptor type 4, Stromal cell-derived factor 1 receptor, Leukocyte-derived seven transmembrane domain receptor

SwissProt ID

O08565 (Rat), P25930 (Bovin), P56498 (Felca), P61073 (Human), P70658 (Mouse), Q764M9 (Pig), Q9PTF7

Gene ID

7852 (CXCR4), 12767 (Cxcr4), 114447 (cxcr4b)

Available reactivities

Fe (Feline), Hu (Human), Ms (Mouse), Rt (Rat), Macaque, Mky (Monkey), Bab (Baboon), Chimp (Chimpanzee), Bov (Bovine), Xen (Xenopus), Rb (Rabbit), Ze (Zebrafish), Can (Canine), Por (Porcine), Sh (Sheep), Chk (Chicken), Hst (Hamster), Op (Opossum), Tr (Turkey), L (Lizard)

Available hosts

Mouse, Rabbit, Goat, Chicken, Rat

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Neutralisation (NEUT), Functional assay (FN), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of CD184 / CXCR4 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other nonhemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2).
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CXCR have been characterized.
CXCR4 is the receptor for the stromal cell derived factor 1(SDF1), that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. The CXCR4 is identified as a co-factor required for the entry of lymphotropic HIV isolates n CD4+ T lymphocytes (1). The CXCR4 gene contains two exons separated by an intronic sequence. A 2.6 kb 5’-flanking region located upstream the CXCR4 open reading frame contains a TATA box and the transcription start site characteristic of a functional promoter. This region also has binding motifs for different transcription factors associated with hemopoiesis and lymphocyte development (3).
The CXCR4 receptor protein is approximately 45kDa (360 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The all CXCR sequence analyses suggest the presence of 7 transmembrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites.

General readings

This product has been used in:Bieniasz PD et al. Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1. J Virol 71:7097-100 (1997). PubMed PMID: 9261443
Heesen M et al. Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor. J Immunol 157:5455-60 (1996). PubMed PMID: 8955194
3. Belmadani, A., et al. The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J. Neurosci. 25(16):3995-4003, 2005.
4. Nishiumi, F., et al. The mode and molecular mechanisms of the migration of presumptive PGC in the endoderm cell mass of Xenopus embryos. Dev. Growth Differ. 47(1):37-48, 2005.
5. Tran, P.B., et al. Chemokine recpetors are expressed widely by embryonic and adult neural progenitor cells. J. Neurosci. Res. 76(1):20-34, 2004.
6. Kayali, A.G., et al. The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J. Cell Biol. 163(4):859-869, 2003.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD184 / CXCR4 antibody

Western blot (WB) analysis of CXCR-4 antibody (Cat.-No AP01296PU-N) at 1/500 dilution Lane 1: Hela whole cell lysate Lane 2: Raw264.7 whole cell lysate Lane 3: H9C2 whole cell lysate. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD184 / CXCR4 (N-term) antibody

Western blot analysis of CXCR4 in HeLa whole cell lysate with CXCR4 antibody at 0.5 ug/ml. Rabbit IgG Purified Hu, Ms E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Human HMEC-1, A549; Immunohistochemistry with HMEC-1 and A549 cells tissue; CXCR4 antibody - N-terminal region (ARP30799_P050) in Human HMEC-1, A549 cells using Immunohistochemistry Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD184 / CXCR4 antibody

Human placenta stained with Anti-CD184/CXCR4 antibody (Cat#AP15509PU). Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD184 / CXCR4 antibody

Human placenta stained with Anti-CD184/CXCR4 antibody (Cat#AP15509PU). Rabbit Purified Hu P
0.1 ml / €180.00
  Acris Antibodies GmbH

CD184 / CXCR4 (Extracell. Dom.) antibody

Western blot analysis of CXCR4 in HeLa total cell lysate with anti-CXCR4 (EL) at 1:1000 dilution. Rabbit IgG Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western blot analysis of CXCR4 in (A) human spleen and (B) human thymus tissue lysate with CXCR4-Lo antibody at 10 ug/ml. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) membranes: 1, 2. Anti-CXCR4 (extracellular) antibody, (1:200). 3, 4. Anti-CXCR4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western Blot: CXCR4 Antibody [TA336358] - Analysis of 15 ug of whole cell lysate from HeLa cells with anti-CXCR4 at 1 ug/ml. Rabbit Purified Hu, Ms, Rt, Sh C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western Blot: CXCR4 Antibody [TA336493] - Analysis of CXCR4 in HeLa whole cell extract. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western Blot: CXCR4 Antibody [TA336837] - WB analysis of CXCR4 in  A. HeLa and B. A431 cell lysate. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 (N-term extracell. dom.) antibody

Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Elephant, Hu, Mky, Ms, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

CD184 / CXCR4 (3rd Cytopl. Dom.) antibody

Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Chk, Elephant, Hst, Hu, L, Mky, Ms, Op, Rb, Rt, Tr P
50 µg / €379.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Western blot analysis of CXCR4 expression in K562 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Immunohistochemical staining of human duodenum shows distinct membranous and cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Epitopes were defined by homologous scanning mutagenesis using human-mouse CXCR4 chimeras. Note: this method defines the key contact points and the complete set of contacts will likely be broader. Mouse IgG2b 772AA17 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Epitopes were defined by homologous scanning mutagenesis using human-mouse CXCR4 chimeras. Note: this method defines the key contact points and the complete set of contacts will likely be broader. Mouse IgG2a 772AA80 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD184 / CXCR4 antibody

Antagonist activity of CXCR4 antibody clone 772X132 Mouse IgG2a 772X132 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

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