CD191 / CCR1 antibody

Principal name

CD191 / CCR1 antibody

Alternative names for CD191 / CCR1 antibody

C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alpha Receptor, RANTES-R

SwissProt ID

P32246 (Human), P51675 (Mouse)

Gene ID

1230 (CCR1)

Available reactivities

Hu (Human), Bov (Bovine), Mky (Monkey), Ms (Mouse), Rt (Rat), Gorilla

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of CD191 / CCR1 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other nonhemopoietic cells. Chemokine receptors (CCR) belong to the superfamily of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as coreceptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2).
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CCR have been characterized (Table1).
CCR1 has been implicated in IL8 induced chemotaxis of melanoma cells. The nonresponsive WM35 melanoma cells when stimulated by TNF express higher levels of CXCR1 and exhibit chemotactic towards interleukin-8 (3). Stimulation of CXCR1 also induce focal adhesion kinase (FAK) phosphorylation, that regulate the chemotactic activities of the migrating cells (4). On the contrary, glucocorticoid/dexamethasone has potent anti-inflammatory effects, yet it up-regulates expression of CXCR4 but not that of CXCR1 and CXCR3 (4).
The CXCR receptor protein is approximately 45-55 kDa (405 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The all CXCR sequence analyses suggest the presence of 7 transmembrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites.

General readings

General / background references:Neote K et al. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72:415-25 (1993). PubMed PMID: 7679328
2. Su, S.B., et al. Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1 expression of various types of leukocytes. J. Leukoc. Biol. 60(5):658-666, 1996.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD191 / CCR1 (2nd Extracell. Dom.) antibody

Anti-CCR1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Hu, Mky, Ms P
50 µg / €345.00
  OriGene Technologies, Inc.

CD191 / CCR1 antibody

Anti-CCR1 antibody IHC of human small intestine, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu
50 µg / €345.00
  OriGene Technologies, Inc.

CD191 / CCR1 antibody

Western Blot: CCR1 Antibody [TA336335] - A375 lysate probed with CCR1 antibody at 2 ug/ml dilution. Rabbit Purified Hu, Ms F, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD191 / CCR1 antibody

Immunohistochemistry-Paraffin: CCR1 Antibody [TA337191] - Analysis of spleen (lymphocytes) using  this antibody at 5 ug/ ml. Rabbit Purified Hu C, P
50 µg / €325.00
  OriGene Technologies, Inc.

CD191 / CCR1 antibody

CD191 / CCR1 Mouse IgG1 141-2 Azide Free Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD191 / CCR1 antibody

Flow cytometric analysis of CCR1 expression on human peripheral blood lymphocytes (left) and peripheral monocytes (right). Shaded histogram indicates the reaction of isotypic control to the cells. Open histogram indicates the reaction of AM26437RP-N to the cells. Mouse IgG1 141-2 PE Hu F
50 Tests / €390.00
  Acris Antibodies GmbH

CD191 / CCR1 (305-319) antibody

CD191 / CCR1 Mouse IgG1 293 Purified Hu E
0.5 mg / €470.00
  Acris Antibodies GmbH

CD191 / CCR1 antibody

Western blot analysis of CCR1 in A357 cell lysate. Rabbit Aff - Purified Hu WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD191 / CCR1 antibody

Lung: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD191 / CCR1 Control Peptide

CD191 / CCR1
0.25 mg / €250.00
  Acris Antibodies GmbH

CD191 / CCR1 (7-24) antibody

CD191 / CCR1 Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD191 / CCR1 (7-24) antibody

Formalin-Fixed, Paraffin-Embedded tissue stained with CCR1 antibody Cat.-No AP31997PU-N at 5 µg/ml after heat-induced antigen retrieval. Goat Aff - Purified Hst, Hu, Mky, Prim E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD191 / CCR1 antibody

Western blot analysis of 10 µg of total cell lysate from A-375 cells with CCR1 polyclonal antibody ( Cat # PAB0176 ) at 2 µg/ml dilution. Rabbit Hu, Ms F, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CD191 / CCR1 antibody

Western blot analysis of CCR1 expression in Jurkat cell lysate. Rabbit Hu, Mky, Ms WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CD191 / CCR1 antibody

CCR1 staining of Paraffin-embedded tissue sections of human tonsil. Tissues were stained using HRP-DAB (brown) and Haematoxylin (blue) counterstain. Mouse IgG2b 53504 Purified Hu F, P
0.1 mg / €410.00
  Neuromics Antibodies

CD191 / CCR1 antibody

IH of paraffin embedded section of human spleen. Rabbit Aff - Purified Hu E, F, P, WB
50 µl / €360.00
  Novus Biologicals Inc.

CD191 / CCR1 antibody

CD191 / CCR1 Goat Aff - Purified Hu E, ICC/IF, WB
50 µg / €360.00
  Novus Biologicals Inc.

CD191 / CCR1 antibody

Western Blot: CCR1 Antibody [NBP1-45469] - Western blot analsysis
of CCR1 in Jurkat cell
lysate. Rabbit IgG Aff - Purified Hu, Mky, Ms WB
0.1 mg / €440.00
  Novus Biologicals Inc.

CD191 / CCR1 antibody

CD191 / CCR1 Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

CD191 / CCR1 antibody

CD191 / CCR1 Rabbit FITC Ms, Rt E
0.1 mg / €540.00
  Novus Biologicals Inc.

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