CD192 / CCR2 antibody

Principal name

CD192 / CCR2 antibody

Alternative names for CD192 / CCR2 antibody

C-C CKR-2, CC-CKR-2, CCR-2, CMKBR2, C-C chemokine receptor type 2, Monocyte chemoattractant protein 1 receptor, MCP1-Receptor

SwissProt ID

O55193 (Rat), P41597 (Human), P51683 (Mouse)

Gene ID

729230 (CCR2), 60463 (Ccr2), 12772

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD192 / CCR2 antibody

CCR2 is a major chemokine receptor expressed on monocytes and its activation through its ligands MCP1, MCP2, MCP3 and MCP4 (systematic mes CCL2, CCL8, CCL7 and CCL13, respectively) stimulates the migration of monocytes across the vascular wall into tissues wherein they facilitate chronic inflammation. CCR2 is a member of GPCR1 family and is up-regulated by CREB3. It is a multi-pass membrane protein found in cell membrane, and besides monocytes, it is also found on other cell types like NK cells, macrophages, immature dendritic cells, gamma delta T cells, and activated T cells (including Th17 cells). There are two altertively spliced forms of CCR2: CCR2A - the major isoform expressed by mononuclear cells and vascular smooth muscle cells; and CCR2B - expressed predomintly by monocytes and activated NK cells. CCR2 has both pro-inflammatory (mediated by APC and T cells) and anti-inflammatory (mediated by regulatory T cells) activities. Besides inflammation, it has been implicated several pathologies including HIV-1/AIDS, autoimmune disorders (psoriasis, rheumatoid arthritis, and multiple sclerosis), pulmory diseases (asthma, COPD), vascular disease and cancer (prostate cancer).

General readings

Charo, I.F., et al., (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 2752-2756.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD192 / CCR2 antibody

  Rabbit polyclonal anti-CCR2 antibody  
Western blot analysis of CCR2 expression in lysate from rat kidney (Lane 1), 3T3 cells (Lane 2) and Jurkat cells (Lane 3). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €353.00
  OriGene Technologies, Inc.

CD192 / CCR2 antibody

Immunohistochemistry on paraffin sections: Staining with AM26722PU-N on Human tonsil. Mouse IgG2a 7A7 Purified Hu C, P
0.2 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Ccr2 - mouse gene knockout kit via CRISPR

Ccr2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr2 - mouse gene knockout kit via CRISPR

Ccr2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr2 - mouse gene knockout kit via CRISPR

Ccr2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr2 - mouse gene knockout kit via CRISPR

Ccr2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CCR2 overexpression lysate

CCR2 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CCR2 (mGFP-tagged) - Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant A, 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR2 (mGFP-tagged) - Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant A, 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCR2 (mGFP-tagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR2 (mGFP-tagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €958.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCR2 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR2 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €855.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ccr2 (GFP-tagged) - Mouse chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccr2 (GFP-tagged) - Mouse chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ccr2 (Myc-DDK-tagged) - Mouse chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccr2 (Myc-DDK-tagged) - Mouse chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ccr2 (GFP-tagged ORF) - Rat chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccr2 (GFP-tagged ORF) - Rat chemokine (C-C motif) receptor 2 (Ccr2), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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