CD194 / CCR4 antibody

Principal name

CD194 / CCR4 antibody

Alternative names for CD194 / CCR4 antibody

C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CMKBR4, K5-5

SwissProt ID

P51679 (Human), P51680 (Mouse), Q8MJW8 (Canfa)

Gene ID

1233 (CCR4), 12773 (Ccr4)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Mky (Monkey), Eq (Equine), Hst (Hamster), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear, Gorilla, Bt (Bat), Op (Opossum)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP)

Background of CD194 / CCR4 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CCR) belong to the superfamily of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2).
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CCR have been characterized (Table1). The CCR4 recrptors are activated by its ligand CCL17/TARC. CCR4 has been implicated Not complex function parallel to or down stream of the bur1/2 that facilitate trimethylation of Histone H3 and regulate the transcription activity (3). CCR4 is also involved in the chodrogenesis of mesenchymal stem cells, this process is influenced by many molecules including CXCL1, FIT3L, CCR3 and CCR4. The induction of CCR4 positive cell in duodenuim affects the food allergy, in skin-tropic condition, in allergic bronchopulmonary aspergillosis (ABPA) is a rare variant of severe asthma resulting from hypersensitivity to Aspergillus fumigatus. The expression of CCR4 is decreases in several autoimmune diseases such as diabetes type1 and rheumatoid arthritis.
The CCR4 receptor protein is approximately 45 kDa (360 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The CCR4 receptors are activated by Thymus and activation-regulated chemokine (TARC) that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites.

General readings

Nakayama,T., (2008) Oncogene 27 (23), 3221-3232

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD194 / CCR4 antibody

  Mouse anti-CCR4 monoclonal antibody  
Immunostaining for CCR-4 in anaplastic large-cell lymphoma, showing membrane and granular cytoplasmic reactivity in all tumor cells while admixed small lymphocytes are negative. Mouse IgG1 Purified Hu ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD194 / CCR4 antibody

  CCR4 Rabbit Polyclonal (N-Terminus) Antibody  
Anti-CCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky, Por
50 µg / €400.00
  OriGene Technologies, Inc.

CD194 / CCR4 (C-term) antibody

  CCR4 Rabbit Polyclonal (C-Terminus) Antibody  
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hst, Hu, Mky, Op, Prim, Rb P
50 µg / €400.00
  OriGene Technologies, Inc.

CD194 / CCR4 antibody

  CCR4 Rabbit Polyclonal (C-Terminus) Antibody  
Anti-CCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu E, P
50 µg / €400.00
  OriGene Technologies, Inc.

CD194 / CCR4 antibody

  CCR4 Rabbit Polyclonal (Extracellular Domain) Antibody  
Anti-CCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

CD194 / CCR4 antibody

  Rabbit Polyclonal Anti-CCR4 Antibody  
WB Suggested Anti-CCR4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysateCCR4 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD194 / CCR4 (Extracell. Dom.) antibody

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Prim, Rb E, F, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD194 / CCR4 antibody

AP26357PU-N: Western blot analysis of CCR4 using Jurkat cell lysates. Rabbit Aff - Purified Can, Hu, Ms WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD194 / CCR4 antibody

Figure 2: Spectral Confocal Microscopy of CHO cells using KH-4F5 antibody (Cat.#DM1232). CHO cells were transiently transfected with an expression vector encoding CCR4. Binding of KH-4F5 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue). Mouse IgG2a KH-4F5 Purified Hu E, F, ICC/IF
0.1 mg / €360.00
  Acris Antibodies GmbH

CD194 / CCR4 antibody

Immunofluorescence analysis of HuvEc cells, using CCR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €230.00
  Assay Biotech

CD194 / CCR4 antibody

Immunofluorescence analysis of HuvEc cells, using CCR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CCR4 - human gene knockout kit via CRISPR

CCR4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CCR4 - human gene knockout kit via CRISPR

CCR4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCR4 - human gene knockout kit via CRISPR

CCR4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCR4 - human gene knockout kit via CRISPR

CCR4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr4 - mouse gene knockout kit via CRISPR

Ccr4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ccr4 - mouse gene knockout kit via CRISPR

Ccr4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr4 - mouse gene knockout kit via CRISPR

Ccr4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccr4 - mouse gene knockout kit via CRISPR

Ccr4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CCR4 (mGFP-tagged) - Human chemokine (C-C motif) receptor 4 (CCR4), 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR4 (mGFP-tagged) - Human chemokine (C-C motif) receptor 4 (CCR4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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