CD196 / CCR6 antibody

Principal name

CD196 / CCR6 antibody

Alternative names for CD196 / CCR6 antibody

C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, CKRL3, CMKBR6, GPR29, STRL22, DRY6, GPR-CY4, LARC receptor, G-protein coupled receptor 29, Chemokine receptor-like 3

SwissProt ID

O54689 (Mouse), P51684 (Human)

Gene ID

1235 (CCR6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Gorilla

Available hosts

Rabbit, Goat, Mouse, Chicken

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Dot blot (Dot)

Background of CD196 / CCR6 antibody

Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The a- and b- families, with four cysteine residues, are the largest and best characterized. In the a-family, one amino acid separates the first two cysteine residues (CXC); in the b-family the two cysteine residues (CC) are adjacent to each other. The a-chemokines that contain the N-terminal Glu-Leu-Arg amino acid sequence (ELR-motif) are chemotactic for neutrophils (such as IL-8), while those that do not, act on lymphocytes (such as IP-10 and MIG). Examples of chemokines under the b-family category are MCP1-5 and RANTES. The chemokine lymphotactin belongs to the g-family, with only two cysteines (C), and the recently described fractalkine or neurotactin is a member of the *-family and has the first two cysteine residues separated by three amino-acids (CXXXC).Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells.1 Receptor expression has also been found to be constitutive (including down regulation), inducible or restricted to a cell state of activation. In addition, some chemokine receptors are also expressed in non-hematopoietic cells, such as nerve, endothelial and epithelial cells. This suggests that chemokines have other roles besides leucocyte chemotaxis. CX3CR1, for example, is highly expressed in adult brain.Chemokine receptors are linked to phospholipases through the Gi class of G proteins (inhibition by pertussis toxin). Receptor activation leads to a cascade of cellular events including generation of inositol triphosphate, calcium release and activation of protein kinase C. Chemokine receptors also activate small GTP-binding proteins of the Ras and Rho families, the latter being involved in cell motility events. In addition, chemokines bind to non-signaling molecules such as the Duffy antigen receptor for chemokines (DARC) which may act to remove chemokines from the circulation, and heparan sulfates proteoglycans which may serve to establish an ECM concentration gradient.CCR-6 (previously referred to as the GPR-CY4, CKRL3, or STRL22 orphan receptor) binds MIP-3\. It is a CC chemokine receptor that is highly expressed in human dendritic cells derived from CD34+ cord blood precursors.2-4 In addition to dendritic cells, CCR-6 mRNA has also been detected in lymphocytes (CD4 and CD8 T cells and B cells), but not in natural killer cells, monocytes and granulocytes."

General readings

General / background references:Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). PubMed PMID: 9786026
Greaves DR et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med 186:837-44 (1997). PubMed PMID: 9294138
Baba M et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem 272:14893-8 (1997). PubMed PMID: 9169459

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD196 / CCR6 (2nd Cytopl. Dom.) antibody

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hst, Hu, Mky, Ms, Prim P
50 µg / €345.00
  OriGene Technologies, Inc.

CD196 / CCR6 (2nd Extracell. Dom.) antibody

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Op, Prim P
50 µg / €345.00
  OriGene Technologies, Inc.

CD196 / CCR6 antibody

Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

CD196 / CCR6 (N-term) antibody

Western blot analysis on Raji cells: Cell lysates of Raji (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CCR6 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4C6 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

CD196 / CCR6 (N-term) antibody

Western blot analysis on Raji cells: Cell lysates of Raji (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CCR6 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4C6 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

CD196 / CCR6 (18-46) antibody

AP08829PU-N staining CCR6 at 5 µg/ml in paraffin-embedded Human Tonsil by Immunohistochemistry. Goat IgG Aff - Purified Hu, Mky, Prim E, F, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD196 / CCR6 Control Peptide

CD196 / CCR6
0.25 mg / €250.00
  Acris Antibodies GmbH

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit Aff - Purified Hu, Mky C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD196 / CCR6 (C-term) antibody

CCR6 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD196 / CCR6 antibody

Western blot analysis of cell lysates of Raji ( 30 µg ) were resolved by SDS - PAGE , transferred to NC membrane and probed with CCR6 monoclonal antibody , clone 4C6 ( 1 : 500 ) ( Cat # MAB1116 ) . Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4C6 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit Hu IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CD196 / CCR6 antibody

Immunohistochemical staining of CCR6 on formalin fixed, paraffin embedded rat intestine with CCR6 polyclonal antibody ( Cat # PAB12270 ). Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit IgG Aff - Purified Hu, Ms, Rt WB

Regular Price: 0.1 mg / €290.00

Special Price: 0.1 mg / €182.00

  Boster Immunoleader

CD196 / CCR6 antibody

CCR6 Staining of human spleen. Cells were stained using ABC-HRP + AEC and Haematoxylin (blue). Mouse IgG2b 53103 Purified Hu C, F, ICC/IF
0.1 mg / €340.00
  Neuromics Antibodies

CD196 / CCR6 antibody

Immunohistochemistry: CCR 6 Antibody [NB100-713] - Immunohistochemistry on paraffin section of human spleen Goat Aff - Purified Hu, Ms E, F, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CD196 / CCR6 antibody

CD196 / CCR6 Mouse IgG2b 53103,111 Purified Hu F
0.1 mg / €340.00
  Novus Biologicals Inc.

CD196 / CCR6 antibody

CD196 / CCR6 Mouse IgG1 4C6 Purified Hu E, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

CD196 / CCR6 antibody

Western Blot: CCR6 Antibody [NBP1-31236] - Western blot analysis of CCR6 Antibody on: A: Hep G2 B: Molt-4 C: Raji 12% SDS PAGE diluted at 1:1000 Rabbit IgG Hu Dot, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit IgG Hu, Ms, Rt P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit FITC Ms, Rt E
0.1 mg / €540.00
  Novus Biologicals Inc.

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