CD196 / CCR6 antibody

Principal name

CD196 / CCR6 antibody

Alternative names for CD196 / CCR6 antibody

C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, CKRL3, CMKBR6, GPR29, STRL22, DRY6, GPR-CY4, LARC receptor, G-protein coupled receptor 29, Chemokine receptor-like 3

SwissProt ID

O54689 (Mouse), P51684 (Human)

Gene ID

1235 (CCR6), 12458 (Ccr6)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Prim (Primate), Hst (Hamster), Op (Opossum), Gorilla

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of CD196 / CCR6 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CCR) belong to the superfamily of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2).
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CCR have been characterized (Table1). The CCR4 receptors are activated by its ligand CCL17/TARC. CCR4 has been implicated Not complex function parallel to or down stream of the bur1/2 that facilitate trimethylation of Histone H3 and regulate the transcription activity (3). CCR4 is also involved in the chodrogenesis of mesenchymal stem cells, this process is influenced by many molecules including CXCL1, FIT3L, CCR3 and CCR4. The induction of CCR4 positive cell in duodenuim affects the food allergy, in skin-tropic condition, in allergic bronchopulmonary aspergillosis (ABPA) is a rare variant of severe asthma resulting from hypersensitivity to Aspergillus fumigatus. The expression of CCR4 is decreases in several autoimmune diseases such as diabetes type1 and rheumatoid arthritis.
The CCR6 receptor protein is approximately 45 kDa (360 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The CCR4 receptors are activated by Thymus and activation-regulated chemokine (TARC) that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD196 / CCR6 (2nd Cytopl. Dom.) antibody

  CCR6 Rabbit Polyclonal (Cytoplasmic Domain) Antibody  
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hst, Hu, Mky, Ms, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

CD196 / CCR6 (2nd Extracell. Dom.) antibody

  CCR6 Rabbit Polyclonal (Extracellular Domain) Antibody  
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Op, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

CD196 / CCR6 antibody

  CCR6 Rabbit Polyclonal (C-Terminus) Antibody  
Anti-CCR6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

CD196 / CCR6 antibody

  Rabbit Polyclonal Anti-CCR6 Antibody  
CD196 / CCR6 Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD196 / CCR6 (N-term) antibody

Western blot analysis on Raji cells: Cell lysates of Raji (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CCR6 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4C6 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

CD196 / CCR6 (N-term) antibody

Western blot analysis on Raji cells: Cell lysates of Raji (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CCR6 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 4C6 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

CD196 / CCR6 (18-46) antibody

AP08829PU-N staining CCR6 at 5 µg/ml in paraffin-embedded Human Tonsil by Immunohistochemistry. Goat IgG Aff - Purified Hu, Mky, Prim E, F, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD196 / CCR6 Control Peptide

CD196 / CCR6
0.25 mg / €250.00
  Acris Antibodies GmbH

CD196 / CCR6 antibody

CD196 / CCR6 Rabbit Aff - Purified Hu, Mky C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD196 / CCR6 (C-term) antibody

CCR6 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD196 / CCR6 antibody

CCR6 Staining of human spleen. Cells were stained using ABC-HRP + AEC and Haematoxylin (blue). Mouse IgG2b 53103 Purified Hu C, F, ICC/IF
0.1 mg / €340.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

CCR6 - human gene knockout kit via CRISPR

CCR6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CCR6 - human gene knockout kit via CRISPR

CCR6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCR6 - human gene knockout kit via CRISPR

CCR6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCR6 - human gene knockout kit via CRISPR

CCR6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CCR6 overexpression lysate

CCR6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CCR6 overexpression lysate

CCR6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CCR6 (mGFP-tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR6 (mGFP-tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCR6 (mGFP-tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR6 (mGFP-tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCR6 (Myc-DDK tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CCR6 (Myc-DDK tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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