CD197 / CCR7 antibody

Principal name

CD197 / CCR7 antibody

Alternative names for CD197 / CCR7 antibody

C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EVI1, BLR2, MIP-3 beta receptor, EBV-induced G-protein coupled receptor 1

SwissProt ID

P32248 (Human), P47774 (Mouse), Q5MD62 (Bovin)

Gene ID

1236 (CCR7), 12775

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hu (Human), Mky (Monkey), Por (Porcine), Rb (Rabbit), Bear, Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Rat, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F), Neutralisation (NEUT), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Functional assay (FN), Frozen Sections (C)

Background of CD197 / CCR7 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases several subtypes of CCR have been characterized.
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Chemokine receptor type 3 (CCR3) is induced during T cell activation and CCR3 positive cell are enriched at the inflammatory site (2). On the contrary, glucocorticoid dexamethasone has potent anti-inflammatory effects, yet it up-regulates expression of CCR4 but not that of CCR1 and CCR3 (4). The chemokine receptor CCR7 and CXCR4 have been suggested to play important role in cancer invasion and metastasis. CCR7 expression may be associated with lymph node metastasis; moreover, the expression of these receptors can serve as an indicator of poor prognosis in patients with cervical and breast cancer (5). CCR7 and its ligands CCL19 and CCL21 are a chemokine system related to mononuclear cell migration and antigen presentation, and are suggested to play a key role in several autoimmune disordersThe chemokine receptor 7 protein is approximately 52-54kDa protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The CCR7 protein also has a large 3rd intra cellular loop which interacts with G-proteins and other signal transduction molecules. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CCR7-selective antibodies were generated against amino terminal end of the protein that is conserved but unique for CCR7 receptor. This epitope is not expressed in any other CCR or CXCR receptors family members.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD197 / CCR7 (C-term) antibody

Anti-CCR7 antibody IHC of human Bone, Eosinophilic Granuloma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

AP15408PU CCR7 antibody staining of Human Small Intestine. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD197 / CCR7 antibody

AP15408PU CCR7 antibody staining of Human Small Intestine. Rabbit Purified Hu P
1 ml / €440.00
  Acris Antibodies GmbH

CD197 / CCR7 antibody

AP15408PU CCR7 antibody staining of Human Small Intestine. Rabbit Purified Hu P
0.1 ml / €180.00
  Acris Antibodies GmbH

CD197 / CCR7 antibody

Western blot analysis of extracts from COS-7 cells, using CCR7 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

CD197 / CCR7 Rat 3D12 Purified Hu F, P
0.1 mg / €180.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

RBL cell line was transfected to co-express mouse CCR7 and GFP.  These cells were stained on ice for 2 hours with Rat IgG2a kappa Isotype Control PE (left) or 1 ug of Anti-Mouse CD197 (CCR7) Purified (right) followed by F(ab')2 Anti-Rat IgG PE .  GFP expression is shown on the X-axis.  Total viable cells were used for analysis. Rat 4B12 Purified Ms F, IP
0.1 mg / €200.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane: 293T cells, Primary antibody: CCR7 Antibody at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1.5 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Western blot analysis of CCR7 in human spleen tissue lysate with CCR7 antibody at 1 ug/ml. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Western blot analysis of Jurkat (lanes 1 and 4), MOLT-4 (lanes 2 and 5) and J774A.1 (lanes 3 and 6) cell lysates: 1-3. Anti-CCR7 (extracellular) antibody, (1:200). 4-6. Anti-CCR7 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD197 / CCR7 (1st Extracell. Dom.) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hu, Mky, Por, Rb P
50 µg / €379.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Western blot analysis on COS7 cell lysate using CCR7 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Western blot analysis of CCR7 expression in K562 Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD197 / CCR7 antibody

Flow cytometric analysis of human CCR7 (right) and isotypic control (left) expression on human whole blood. The staining intensity of AM26446AF and isotypic control are shown in the horizontal axis with human CD4 staining on the vertical axis. Mouse IgG1 6B3 Azide Free Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD197 / CCR7 antibody

Western blot (WB) analysis of CCR7 antibody (Cat.-No.: AP01295PU-N) at 1/500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate lysate Lane3:PC12 cell lysate lysate Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD197 / CCR7 Control Peptide

CD197 / CCR7
0.25 mg / €250.00
  Acris Antibodies GmbH

CD197 / CCR7 antibody

CD197 / CCR7 Rabbit Aff - Purified Hu, Ms, Rt C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD197 / CCR7 (C-term) antibody

Western blot analysis of spleen sections using CCR7 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD197 / CCR7 (C-term) antibody

Kidney (Formalin-fixed paraffin section, human) Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

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