CD202b / TEK antibody

Principal name

CD202b / TEK antibody

Alternative names for CD202b / TEK antibody

TIE2, TIE-2, Angiopoietin-1 receptor, p140 TEK, Tyrosine-protein kinase receptor TIE-2, Tyrosine-protein kinase receptor TEK, Tunica interna endothelial cell kinase

SwissProt ID

Q02763 (Human), Q02858 (Mouse), Q06807 (Bovin)

Gene ID

7010 (TEK), 83659 (TEKT1), 21687

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Ze (Zebrafish)

Available hosts

Goat, Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of CD202b / TEK antibody

The tyrosine kinase receptor TIE-2 was initially identified as a specific endothelial growth factor receptor that mediated several properties of endothelial cells under both physiologcal and pathological conditions. Angiopoietins are the natural ligands of TIE-2 and they induce TIE-2-dependant signalling, including survival and apoptosis of endothelial cells, vascular permeability and regulate capillary sprouting. TIE-2 plays an important role in several vascular diseases, known as vascular malformation (e.g. venous malformation). Independent of angiogenesis and its involvement in lymphangiogenesis, TIE-2 maintains a long-term, quiescent population of hematopoietc stems cells in the bone marrow. In a tumor model, a subset of monocytes was found to be positve for TIE-2 and that they have an important function in paracrine support of nascent blood vessels. A natural occuring soluble TIE-2 receptor fragment of 75 kDa (sTIE-2) is generated by shedding. Soluble TIE-2 inhibits angiopoietin-mediated TIE-2 phosphorylation and anti-apoptosis. TIE-2 shedding is mediated by PI2K/Akt and p38 MAPK. The serum levels of sTIE-2 in patients is in the lower ng/ml range and dependent of the disease. Soluble TIE-2 was also measured in preterm infants including the ROP syndrome (retinopathy of prematurity). Elevated plasma levels in active ROP patients were observed for sTIE-2. In experimental tumor mouse models sTIE-2 can be used for tumor regression and prolonged the tumor-free survival in 80% of the animals.

General readings

Sato TN et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376:70-4 (1995). PubMed PMID: 7596437
Sato TN et al. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A 90:9355-8 (1993). PubMed PMID: 8415706
Partanen J et al. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol Cell Biol 12:1698-707 (1992). PubMed PMID: 1312667

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD202b / TEK antibody

Immunohistochemistry with Human spleen cryo-sections using monoclonal anti-Human TIE-2 antibody. The experiment was performed by Prof. Dr. Birte Steiniger, Institute of Anatomy and Cell Biology Robert-Koch-Str. 8, D-35037 Marburg, Germany   Mouse IgG1 Cl.16 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK (C-term) antibody

(LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (RIGHT) Formalin-fixed and paraffin-embedded human testis tissue reacted with TEK Antibody (C-term) (Cat#AP14429PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Western blot analysis of extracts from HepG2 cells, using TIE2 (Ab-992) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and liver cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TEK antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Predicted cell location: Cytoplasm . Positive control: Human liver and lung cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TEK antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Western Blot: TIE2 Antibody [TA336811] - Detection of TIE2 in Huvec cell lysate Rabbit Purified Hu, Ms C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

A typical staining pattern with the B-B48 monoclonal antibody of Eahy 926 cell line Mouse IgG1 B-B48 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

A typical staining pattern with the B-B48 monoclonal antibody of Eahy 926 cell line Mouse IgG1 B-B48 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD202b / TEK pTyr1113 antibody

Dot blot analysis of anti-Phospho-TEK pTyr1113 Antibody (Cat.#AP12973PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Human recombinant sTIE-2. There is a strong cross reactivity with Mouse sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Hu, Ms WB
0.2 mg / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Human recombinant sTIE-2. There is a strong cross reactivity with Mouse sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 with a Polyclonal antibody directed against Mouse recombinant sTIE-2. There is a very weak cross reactivity with Human sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Ms F, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 with a Polyclonal antibody directed against Mouse recombinant sTIE-2. There is a very weak cross reactivity with Human sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Ms F, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK pTyr992 antibody

Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody AP55775PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CD202b / TEK pTyr992 antibody

Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody AP55775PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
50 µl / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Immunohistochemistry with cryo-sections using monoclonal anti-Human TIE-2 antibody Mouse IgG1 Cl.2 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Quantification of soluble and cellular TIE-2 by Sandwich ELISA: A. CM and cell lysates from HUVECs treated with PMA (25ng/ml) or left untreated were analysed by Sandwich ELISA for the concentrations of sTIE-2 or TIE-2. For Capturing anti-Human TIE-2 Cl.16 (Cat.-No DM3511) was used. for the detection a mixture of biotinylated anti-human TIE-2 Cl.2 (Cat.-No DM3509B) and Cl.9 (Cat.-No DM3510). Mouse IgG1 Cl.2 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Immunohistochemistry with cryo-sections using monoclonal anti-Human TIE-2 antibody Mouse IgG1 Cl.9 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

CD202b / TEK Mouse IgG1 Cl.9 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

CD202b / TEK Mouse IgG1 Cl.16 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

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