CD202b / TEK antibody

Principal name

CD202b / TEK antibody

Alternative names for CD202b / TEK antibody

TIE2, TIE-2, Angiopoietin-1 receptor, p140 TEK, Tyrosine-protein kinase receptor TIE-2, Tyrosine-protein kinase receptor TEK, Tunica interna endothelial cell kinase

SwissProt ID

Q02763 (Human), Q02858 (Mouse), Q06807 (Bovin)

Gene ID

7010 (TEK), 21687 (Tek)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Ze (Zebrafish)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), ELISA (detection) (E(detection))

Background of CD202b / TEK antibody

TIE2 (tyrosine-protein kise receptor TIE-2) is an endothelial-selective RTK that is essential to angiopoietin (ANGPT)/TIE2 system which constitutes transmembrane endothelial tyrosine kise TIE2 and its circulating ligands (ANGPT-1, -2 and ANGPT-3, -4). Activation/phosphorylation state of TIE2 regulates the baseline endothelial quiescence and its response to pathogens as well as cytokines, and TIE2 phosphorylation is largely controlled by the ratio of agonistic ligand ANGPT-1 and competitive inhibitor ANGPT-2. TIE2 exists as homodimer or heterodimer (with TIE1) and interacts with ANGPT1, ANGPT2, ANGPT4, TEK , TNIP2, SHC1, PTPRB, DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2 etc for exerting its diverse biological functions. TIE2 regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion, actin cytoskeleton reorganization, and maintence of vascular quiescence. It exerts anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, and activates or inhibits angiogenesis, depending on the context (inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts). Targeted deletion of TIE2 or its major agonist ligand, Angpt-1, results in embryonic lethality in mice characterized by defects in blood vessel maturation, lack of recruitment of supporting pericytes and impaired basement membrane formation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD202b / TEK antibody

Immunohistochemistry with Human spleen cryo-sections using monoclonal anti-Human TIE-2 antibody. The experiment was performed by Prof. Dr. Birte Steiniger, Institute of Anatomy and Cell Biology Robert-Koch-Str. 8, D-35037 Marburg, Germany   Mouse IgG1 Cl.16 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK (C-term) antibody

(LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (RIGHT) Formalin-fixed and paraffin-embedded human testis tissue reacted with TEK Antibody (C-term) (Cat#AP14429PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Western blot analysis of extracts from HepG2, using TIE2 (Phospho-Tyr992) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Western blot analysis of extracts from HepG2 cells, using TIE2 (Ab-992) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and liver cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TEK antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Predicted cell location: Cytoplasm . Positive control: Human liver and lung cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TEK antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

Western Blot: TIE2 Antibody [TA336811] - Detection of TIE2 in Huvec cell lysate Rabbit Purified Hu, Ms C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD202b / TEK antibody

A typical staining pattern with the B-B48 monoclonal antibody of Eahy 926 cell line Mouse IgG1 B-B48 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

A typical staining pattern with the B-B48 monoclonal antibody of Eahy 926 cell line Mouse IgG1 B-B48 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD202b / TEK pTyr1113 antibody

Dot blot analysis of anti-Phospho-TEK pTyr1113 Antibody (Cat.#AP12973PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Human recombinant sTIE-2. There is a strong cross reactivity with Mouse sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Hu, Ms WB
0.2 mg / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Human recombinant sTIE-2. There is a strong cross reactivity with Mouse sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 with a Polyclonal antibody directed against Mouse recombinant sTIE-2. There is a very weak cross reactivity with Human sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Ms F, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 with a Polyclonal antibody directed against Mouse recombinant sTIE-2. There is a very weak cross reactivity with Human sTIE-2 but not with Human and Mouse sTIE-1 visible. Rabbit IgG Purified Ms F, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CD202b / TEK pTyr992 antibody

Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody AP55775PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CD202b / TEK pTyr992 antibody

Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody AP55775PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
50 µl / €270.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Immunohistochemistry with cryo-sections using monoclonal anti-Human TIE-2 antibody Mouse IgG1 Cl.2 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Quantification of soluble and cellular TIE-2 by Sandwich ELISA: A. CM and cell lysates from HUVECs treated with PMA (25ng/ml) or left untreated were analysed by Sandwich ELISA for the concentrations of sTIE-2 or TIE-2. For Capturing anti-Human TIE-2 Cl.16 (Cat.-No DM3511) was used. for the detection a mixture of biotinylated anti-human TIE-2 Cl.2 (Cat.-No DM3509B) and Cl.9 (Cat.-No DM3510). Mouse IgG1 Cl.2 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

Immunohistochemistry with cryo-sections using monoclonal anti-Human TIE-2 antibody Mouse IgG1 Cl.9 Purified Hu C, E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD202b / TEK antibody

CD202b / TEK Mouse IgG1 Cl.9 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

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