CD206 / MRC1 antibody

Principal name

CD206 / MRC1 antibody

Alternative names for CD206 / MRC1 antibody

Macrophage mannose receptor, CLEC13D, CLEC13DL, MRC1L1, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Macrophage mannose receptor 1-like protein 1

SwissProt ID

P22897, Q61830

Gene ID

4360 (MRC1), 17533 (Mrc1), 414308 (MRC1L1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Sh (Sheep), Mky (Monkey), Can (Canine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Functional assay (FN), Neutralisation (NEUT)

Background of CD206 / MRC1 antibody

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

General readings

This product has been used in:Noorman F et al. Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages. J Leukoc Biol 61:63-72 (1997). PubMed PMID: 9000538
Barrett-Bergshoeff M et al. Monoclonal antibodies against the human mannose receptor that inhibit the binding of tissue-type plasminogen activator. Thromb Haemost 77:718-24 (1997). PubMed PMID: 9134649
General / background references:Noorman F et al. Cluster mannosides can inhibit mannose receptor-mediated tissue-type plasminogen activator degradation by both rat and human cells. Hepatology 26:1303-10 (1997). PubMed PMID: 9362376

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD206 / MRC1 antibody

Frozen Human Tonsil stained with Mouse anti Human CD206 antibody AM05589PU (Clone 7-450). Mouse IgG2a 7-450 Purified Hu C
0.1 mg / €280.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

Staining of J774 cell line with Rat anti Mouse CD206 following permeabilisation with Leucoperm. Rat IgG2a MR5D3 Purified Ms C, F, ICC/IF, IP
0.25 mg / €560.00
  Acris Antibodies GmbH

CD206 / MRC1 (Extracell. Dom.) antibody

In situ staining of swine skin DCS Mouse IgG1 122D2.08 Purified Hu, Por, Sh C, F, FN, IP, NEUT, WB
50 µg / €330.00
  Dendritics SAS

CD206 / MRC1 (Extracell. Dom.) antibody

In situ staining of swine skin DCS Mouse IgG1 122D2.08 Purified Hu, Por, Sh C, F, FN, IP, NEUT, WB
0.1 mg / €440.00
  Dendritics SAS

CD206 / MRC1 antibody

Western blot analysis of extracts from K562 cells, A549 cells and NIH-3T3 cells, using MRC1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD206 / MRC1 antibody

Frozen Human Tonsil stained with Mouse anti Human CD206 antibody AM05589PU (Clone 7-450). Mouse IgG2a 7-450 Purified Hu C
0.2 mg / €480.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 Low Endotoxin Hu C, F, FN, ICC/IF, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 Purified Hu C, F, FN, ICC/IF, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD206 / MRC1 (N-term) antibody

Western blot analysis in mouse lung tissue lysates (35ug/lane) using CD206 / MRC1 antibody Cat.-No. AP52743PU-N (N-term). This demonstrates this antibody detected the MRC1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 Biotin Hu C, FN, WB
50 µg / €390.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 Purified Hu C, F, WB

Regular Price: 0.2 mg / €540.00

Special Price: 0.2 mg / €350.00

  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse IgG1 15-2 Purified Hu C, F, FN, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Rat IgG2a MR5D3 Biotin Ms F
0.1 mg / €460.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Rat IgG2a MR5D3 FITC Ms F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Rat IgG2a MR5D3 Azide Free Ms C, F, IP, WB
0.5 mg / €670.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Rat IgG2a MR5D3 Purified Ms C, F, ICC/IF, IP
0.1 mg / €380.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Rat IgG2a MR5D3 PE Ms F
100 Tests / €630.00
  Acris Antibodies GmbH

CD206 / MRC1 antibody

CD206 / MRC1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD206 / MRC1 antibody

Immunoperoxidase of monoclonal antibody to MRC1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml] Mouse IgG1 5C11 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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