CD209 / DC-SIGN antibody

Principal name

CD209 / DC-SIGN antibody

Alternative names for CD209 / DC-SIGN antibody

DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, C-type lectin domain family 4 member L

SwissProt ID

Q9NNX6 (Human)

Gene ID

30835 (CD209)

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Sh (Sheep), Can (Canine), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Functional assay (FN), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of CD209 / DC-SIGN antibody

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.
2. Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72.
3. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.
4. Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.
5. Pohlmann S, Soilleux EJ, Baribaud F, et al. DC-SIGNR, a DCSIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc Natl Acad Sci USA. 2001; 98:2670-2675.
6. Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, at el. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 2001; 193:671-8.
7. Mitchell DA, Fadden AJ, Drickamer K. A novel mechanism of
carbohydrate recognition by the C-type lectins DC-SIGN and DCSIGNR: Subunit organisation and binding to multivalent ligands. J Biol Chem. 2001; 276:28939-45.
8. Mummidi S, Catano G, Lam L, et al. Extensive repertoire of membrane-bound and soluble DC-SIGN1 and DC-SIGN2 isoforms: Inter-individual variation in expression of DC-SIGN transcripts. J Biol Chem. 2001; 276:33196-212.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD209 / DC-SIGN antibody

Western blot detection of DC-SIGN in human small intestine at (A) 1 and (B) 2 ug /ml. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

Western blot analysis of DC-SIGN expression in human placenta tissue lysate in the absence (lane 1) and presence (lane 2) of blocking peptide with DC-SIGN antibody at 2 ug /ml. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

Western blot detection of DC-SIGN fusion protein in human placenta at (A) 1 and (B) 2 ug/mL. Mouse IgG 5D7 Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

Western blot detection of DC-SIGN fusion protein in human uterus tissue lysate at (A) 1 and (B) 2 ug/mL. Mouse IgG 8B6 Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

Staining of human monocyte-derived immature dendritic cells with 0.5 ug of Rat IgG2a K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD209 (DC-SIGN) Purified (filled histogram) followed by Anti-Rat IgG FITC .  Cells in the large scatter population were used for analysis. Rat eB-h209 Purified Hu F
25 µg / €150.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

Predicted band size: 46 kDa . Positive control: Jurkat, HUVEC, HepG2 and Hela cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2,3,4: Jurkat, HUVEC, HepG2 and Hela cells Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 DCN47.5 FITC Hu F, FN
0.1 mg / €490.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 DCN47.5 Purified Hu F, FN
0.1 mg / €450.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 UW60.1 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 UW60.1 Aff - Purified Hu F, ICC/IF
0.1 mg / €210.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

AP07694PU-N DC-SIGN antibody staining Formalin-Fixed Paraffin-Embedded Human Tonsil at 5 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

Staining of CD209 transfected K562 cells with MOUSE ANTI HUMAN CD209: FITC (SM2219F) Mouse IgG1 MR-1 FITC Hu F
0.1 mg / €470.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

Flow cytometric analysis using anti CD209 antibody SM2219LE Mouse IgG1 MR-1 Low Endotoxin Hu F, FN, ICC/IF
0.5 mg / €560.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

Staining of CD209 transfected K562 cells with MOUSE ANTI HUMAN CD209 (SM2219P) Mouse IgG1 MR-1 Purified Hu F, ICC/IF
0.2 mg / €530.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 MR-1 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

CD209 / DC-SIGN Mouse IgG1 MR-1 PE Hu F
25 Tests / €210.00
  Acris Antibodies GmbH

CD209 / DC-SIGN (277-293) antibody

Immunohistochemical staining of human small inestine with Rabbit anti Human CD209 antibody Cat.-No SP1337P. Rabbit Aff - Purified Hu C, ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD209 / DC-SIGN antibody

Western Blot analysis of CD209 expression in transfected 293T cell line (H00030835-T01) by CD209 MaxPab polyclonal antibody.

Lane 1: CD209 transfected lysate(44.44 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD209 / DC-SIGN antibody

CD209 MaxPab rabbit polyclonal antibody. Western Blot analysis of CD209 expression in human liver. Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

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