CD21 antibody

Principal name

CD21 antibody

Alternative names for CD21 antibody

Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker, Complement C3d receptor, Epstein-Barr virus receptor

SwissProt ID

P19070 (Mouse), P20023 (Human), Q5NT87 (Canfa), Q8HY44 (Bovin)

Gene ID

1380 (CR2), 9332 (CD163)

Available reactivities

Hu (Human), Bov (Bovine), Fe (Feline), Gt (Goat), Mink, Sh (Sheep), Can (Canine), Por (Porcine), Eq (Equine), Ms (Mouse), Rt (Rat), Deer

Available hosts

Mouse, Rabbit

Available applications

Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Functional assay (FN), Enzyme Immunoassay (E)

Background of CD21 antibody

The CD21 antigen is expressed on mature B cells, follicular dendritic cells and pharyngeal and cervical epithelial cells [1,2]. CD21, also known as the Complement receptor type 2 (CR2) or Epstein-Barr virus (EBV) receptor, is a receptor for the C3 activation fragments iC3b and C3d. CD21 is part of a multimeric complex on B cells which includes CD19 and CD81 [3]. The ligand for CD21 is generated during activation of complement by the attachment of C3d to potential antigen. This creates fusion proteins that may cross-link the CD19-CD21-CD81 complex to sIg on antigen-specific B cells. The resulting signal transduction lowers the threshold for cellular activation. This enables an antibody reaction to natural protein antigens containing only one or a few epitopes and therefore unable to effectively cross-link Ig molecules on specific B cells. For example, keyhole limpet hemocyanin (KLH) immune complexes can be taken up and processed by all CR2-bearing B cells, regardless of their antigen specificity. KLH immune complexes taken up this way by non-specific B cells were shown to be presented to KLH-specific, MHC class II Th cells. CD23 may also serve as a ligand for CD21 [3].

General readings

1. Tedder T.F., L.T. Clement, and Cooper M.D.. Expression of C3d receptors during human B cell differentiation:
Immunofluorescence analysis with the HB-5 monoclonal antibody. J Immunol. 1984:133:678.
2. Denham, S., R.J. Zwart, J.T.D. Whittall, M. Pampusch, A.H. Corteyn, A.T.J. Bianchi, M.P. Murtaugh, R.M.E. Parkhouse, H.
Tlaskalova, J. Sinkora, M. Siinkora, and Z. Rehakova. 1998. Monoclonal antibodies putatively identifying porcine B cells.
Veter. Immunol. Immunopathol. 60:317-328.
3. Pescovitz, M. Personal communication.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD21 antibody

Immunofluorescence staining of human tonsil cryosection using Mouse anti Human CD1a antibody (Cat.No SM1858P), red in A and Mouse anti Human CD21 (Cat.-No SM1785P), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power. Mouse IgG1 LB21 Purified Bov, Fe, Gt, Hu, Mink, Sh C, F, ICC/IF, IP
2 ml / €430.00
  Acris Antibodies GmbH

CD21 antibody

Immunohistochemistry staining of Paraffin Tonsil tissue by CD21 antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous) Mouse IgG2a 2G9 Purified Hu P
1 ml / €770.00
  OriGene Technologies, Inc.

CD21 antibody

Immunohistochemistry staining of Paraffin Tonsil tissue by CD21 antibody (dilution: 1:50 - 1:200; visualization of staining: Membranous) Rabbit IgG EP3093 Purified Hu P
1 ml / €540.00
  OriGene Technologies, Inc.

CD21 (C-term) antibody

Expression of CD21 in follicular dendritic cells - lymphoid follicle of the tonsil, stained with anti-CD21 monospecific clonal antibody (DB 213).Kindly performed and provided by Marián Švajdler, MD andDr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q22-S Aff - Purified Hu P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD21 (C-term) antibody

Expression of CD21 in follicular dendritic cells - lymphoid follicle of the tonsil, stained with anti-CD21 monospecific clonal antibody (DB 213).Kindly performed and provided by Marián Švajdler, MD andDr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q22-S Aff - Purified Hu P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD21 (C-term) antibody

Expression of CD21 in follicular dendritic cells - lymphoid follicle of the tonsil, stained with anti-CD21 monospecific clonal antibody (DB 213).Kindly performed and provided by Marián Švajdler, MD andDr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q22-S Aff - Purified Hu P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD21 (C-term) antibody

Expression of CD21 in follicular dendritic cells - lymphoid follicle of the tonsil, stained with anti-CD21 monospecific clonal antibody (DB 213).Kindly performed and provided by Marián Švajdler, MD andDr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q22-S Aff - Purified Hu P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD21 antibody

CD21 Mouse IgG1 Bu32 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 Bu32 Purified Hu F, IP
0.2 mg / €430.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 Bu32 Purified Hu F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD21 antibody

Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody Mouse IgG1 LT21 FITC Bov, Can, Hu, Por F
100 Tests / €260.00
  Acris Antibodies GmbH

CD21 antibody

Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody. Mouse IgG1 LT21 Purified Bov, Can, Hu, Por C, F
0.1 mg / €210.00
  Acris Antibodies GmbH

CD21 antibody

Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody Mouse IgG1 LT21 PE Bov, Can, Hu, Por F
100 Tests / €290.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 CC21 FITC Bov, Gt, Sh F
0.1 mg / €650.00
  Acris Antibodies GmbH

CD21 antibody


Staining of Bovine peripheral blood lymphocytes with CD21 Antibody Cat.-No AM05516PU-M (clone CC21)
Mouse IgG1 CC21 Purified Bov, Gt, Sh C, F, ICC/IF, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 CC21 PE Bov, Gt, Sh F
100 Tests / €740.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 Bu33 Purified Eq, Hu F
0.2 mg / €430.00
  Acris Antibodies GmbH

CD21 antibody

CD21 Mouse IgG1 Bu33 Purified Eq, Hu F
25 µg / €180.00
  Acris Antibodies GmbH

CD21 antibody

Staining of canine peripheral blood lymphocytes with mouse anti canine CD21 Mouse IgG1 CA2.1D6 Purified Can, Eq, Fe C, F, IP
0.1 mg / €470.00
  Acris Antibodies GmbH

CD21 antibody

This antibody staining of canine peripheral blood lymphocytes Mouse IgG1 CA2.1D6 PE Can, Eq, Fe F
100 Tests / €740.00
  Acris Antibodies GmbH

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