CD217 / IL17RA antibody

Principal name

CD217 / IL17RA antibody

Alternative names for CD217 / IL17RA antibody

IL-17 receptor, IL17R, CDw217, Interleukin-17 receptor A

SwissProt ID

Q60943 (Mouse), Q96F46 (Human)

Gene ID

23765 (IL17RA), 16172 (Il17ra)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Rat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), Neutralisation (NEUT), Frozen Sections (C)

Background of CD217 / IL17RA antibody

Pro inflammatory cytokine, IL-17 (IL-17A or CTLA-8) plays a central role in inflammation and autoimmunity. The IL17, like other cytokines is produce by activation of T cell receptor through CD3 cross linking (4). IL-17 is a crucial effector cytokine, whose production is specifically triggered by IL-23, and it has been shown to be an essential inflammatory mediator in other autoimmune diseases and inflammatory conditions. In human the co-stimulation of T cells thru CD28 several co-stimulatory molecules (ICOS, 4-1BB, CD40L) mildly enhance the IL17 expression where as IL23 profoundly enhance the CD3 induced IL17 expression. The IL-17 expression is also sensitive to cyclosporin-A and MAPK inhibitors, suggesting the involvement of the calcineurin/NFAT and MAPK signaling pathway. IL17 signaling requires its binding to IL17 receptor, IL17 receptor is expression is widespread, the activity of IL17 is most commonly defined by its ability to induce the expression of inflammatory cytokines, chemokines and other mediators by stromal cells. In mouse genetically deficient in IL17RA, the IL17 signaling is poorly compensated by IL17RC suggesting the biological activity of IL17 is dependent on a heteromeric receptor complex composed of IL17RA and IL17RC (2). At least three types of IL17 receptors are cloned and characterized, IL17RA, IL17RB and IL17RC, IL17C is expressed in multiple spliced variant form (IL17RC1, ILRC2, and ILRC3). IL17RA deficient mice also showed high susceptibility and recovery after infusion of IL17A to hemopieotic cytotoxicity to gamma radiation suggesting involvement of IL17R dependent inducible mechanism that is required for recovery of granulopoiesis after radiation injury (3). IL17R is also involvement in allograft rejection and Intragraft IL-17 inhibition may be useful as an adjuvant therapy to systemic immunosuppression in tissue transplantation. www.
The predicted IL17RA receptor (866 aa) is a ubiquitous membrane glycoprotein that binds with low affinity to IL17A suggesting that additional component are involved in IL17-induced signaling. Like other cytokines receptors, IL17RA also has multimeric tructure. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases including rheumatoid arthritis. The IL17RA has at least 3 TMD that anchor the protein to the cell membrane with a large intrcyctoplasmic domain where protein and signaling molecules interact with the receptor complex.

General readings

Gaffen SL, Kramer JM, Yu JJ, Shen F.
The IL-17 cytokine family.
Vitam Horm. 2006;74:255-82. Review.
PMID: 17027518

20 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD217 / IL17RA antibody

TA311387 (1ug/ml) staining of Rat Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

Western blot analysis of extracts from LOVO cells, using IL17RAantibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

Western Blot: IL17RA Antibody (49M4D2) [TA337125] - analysis of an IL-17RA recombinant protein fragment and human heart lysate using IL-17RA antibody at 0.5 and 3 ug/ml, respectively. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate so Mouse IgG1 49M4D2 Purified Hu C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

Western Blot: IL17RA Antibody (49M5D9) [TA337127] - Analysis of an IL-17RA recombinant protein fragment using IL-17RA antibody at 0.5 ug/ml. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Mouse IgG2b 49M5D9 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

Western Blot: IL17RA Antibody (49M7C6) [TA337128] - analysis of an IL-17RA recombinant protein fragment using IL-17RA antibody at 0.5 ug/ml. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Mouse IgG2b 49M7C6 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA antibody

ELISA: IL17RA Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

CD217 / IL17RA Control Peptide

CD217 / IL17RA
0.25 mg / €250.00
  Acris Antibodies GmbH

CD217 / IL17RA (97-115) antibody

CD217 / IL17RA Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD217 / IL17RA (Extracell. Dom.) antibody

CD217 / IL17RA Rat IgG2 10B27 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD217 / IL17RA antibody

Western Blot analysis of IL17RA expression in transfected 293T cell line (H00023765-T01) by IL17RA MaxPab polyclonal antibody.

Lane 1: IL17R transfected lysate(95.26 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD217 / IL17RA antibody

ELISA: IL17RA Antibody [43490002] Rabbit Hu E, WB
50 µg / €530.00
  Novus Biologicals Inc.

CD217 / IL17RA antibody

CD217 / IL17RA Rat IgG2 RM0104-10B27 Purified Ms WB
0.1 mg / €450.00
  Novus Biologicals Inc.

CD217 / IL17RA antibody

CD217 / IL17RA Goat Aff - Purified Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD217 / IL17RA

CD217 / IL17RA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD217 / IL17RA

CD217 / IL17RA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CD217 / IL17RA

CD217 / IL17RA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

ELISA Kits

Catalog No.    

IL17RA (Human) ELISA Kit

IL17RA (Human) ELISA Kit  
1 kit / €590.00
  Abnova Taiwan Corp.

OmniKine™ Human IL-17R ELISA Kit

OmniKine™ Human IL-17R ELISA Kit  
96 Tests / €410.00
  Assay Biotech

Lysates

Catalog No.    

IL17RA 293T Cell Transient Overexpression Lysate(Denatured)

IL17RA 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

20 Item(s)

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