CD218a / IL18R1 antibody

Principal name

CD218a / IL18R1 antibody

Alternative names for CD218a / IL18R1 antibody

Interleukin-18 receptor 1, IL-18 receptor 1, CDw218a, IL-1Rrp, IL1RRP, IL1 receptor-related protein, CD218 antigen-like family member A

SwissProt ID

Q13478 (Human), Q61098 (Mouse)

Gene ID

8809 (IL18R1), 16182 (Il18r1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rat, Rabbit

Available applications

Functional assay (FN), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Neutralisation (NEUT)

Background of CD218a / IL18R1 antibody

Interleukin 18, also known as interferon-gamma inducing factor (IGIF) and IL1 gamma, shares some biologic activities with IL12 and structural similarities with the IL1 family of proteins. It plays an important role in the T cell helper type 1 (Th1) response through its ability to induce IFN-gamma production in T cells and NK cells. IL18 is related to the IL1 family in terms of structure, receptor family and function. Structurally, IL18 and IL1-beta share primary amino acids sequences (signature sequence motif) and are similarly folded as all-beta pleated sheet molecules. Similar to IL1 beta, production of IL18 requires caspase 1 (interleukin 1-beta converting enzyme, ICE) to cleave the pro-domain from the precursor protein to produce active mature IL18. Gene expression and synthesis of TNF, IL1, Fas ligand and several chemokines are induced by IL18. As with IL1, IL18 participates in both innate and acquired immunity. IL18 actions are mediated by an IL18 receptor (IL18R1) complex comprised of a binding chain (IL18 R-alpha, also called IL1 receptor-related protein, IL1 Rrp) and a signal-transducing chain. Both chains are members of the IL1 receptor family. The IL18R1 complex recruits the IL1 R-activating kinase (IRAK) and TNFR associated factor 6 (TRAF6) which phosphorylates NF-kappa-B-inducing kinase (NIK) with subsequent activation of NF-kappa-B.

General readings

Vermot-Desroches C. et al., Cell Immunol., 2005; 236 (1-2):101-104

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD218a / IL18R1 antibody

Western blot analysis of extracts from Jurkat cells, using IL18R antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD218a / IL18R1 antibody

Western blot analysis of Mouse liver tissue using TA322815(IL18R1 Antibody) at dilution 1/200 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD218a / IL18R1 antibody

Western blot analysis of A549 cell using TA322816(IL18R1 Antibody) at dilution 1/200 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD218a / IL18R1 antibody

Western blot analysis of Human thyroid cancer tissue using TA322817(IL18R1 Antibody) at dilution 1/222 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD218a / IL18R1 antibody

WB Suggested Anti-IL18R1 Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD218a / IL18R1 (Extracell. dom.) (1-329) antibody

Flow cytometric analysis of human IL-18R1 expression on KG-1. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26653AF-N to the cells. Mouse IgG1 44G6 Azide Free Hu F
0.1 mg / €360.00
  Acris Antibodies GmbH

CD218a / IL18R1 antibody

CD218a / IL18R1 Mouse IgG1 B-E43 Azide Free Hu FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD218a / IL18R1 antibody

CD218a / IL18R1 Mouse IgG1 B-E43 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD218a / IL18R1 antibody

CD218a / IL18R1 Mouse IgG1 B-E43 PE Hu F
1ml (100T) / €290.00
  Acris Antibodies GmbH

CD218a / IL18R1 (Extracell. Dom.) antibody

CD218a / IL18R1 Rat IgG2 7G31 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD218a / IL18R1 antibody

CD218a / IL18R1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

Western Blot analysis of IL18R1 expression in transfected 293T cell line (H00008809-T01) by IL18R1 MaxPab polyclonal antibody.

Lane 1: IL18R1 transfected lysate(59.51 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

Western Blot analysis of IL18R1 expression in transfected 293T cell line (H00008809-T01) by IL18R1 MaxPab polyclonal antibody.

Lane 1: IL18R1 transfected lysate(59.51 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

CD218a / IL18R1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

Western Blot analysis of IL18R1 expression in transfected 293T cell line (H00008809-T02) by IL18R1 MaxPab polyclonal antibody.

Lane 1: IL18R1 transfected lysate(62.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

CD218a / IL18R1 Mouse IgG2b 3C8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD218a / IL18R1 antibody

Human PANC1; WB Suggested Anti-IL18R1 Antibody Titration: 0.2-1 ug/ml. Positive Control: PANC1 cell lysate; IL18R1 antibody - N-terminal region (ARP46382_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD218a / IL18R1 antibody

Flow Cytometry: IL-18R alpha Antibody (H44) [NB100-77939] - Human peripheral blood lymphocytes stained with purified H44, followed by biotinylated anti-mouseIgG and Sav-PE Mouse IgG1 H44 Aff - Purified Hu C, F, IP, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CD218a / IL18R1 antibody

Flow Cytometry: IL-18R alpha Antibody (H44) [NB100-77940] - Human peripheral blood lymphocytes stained with biotinylated H44, followed by Sav-PE Mouse IgG1 H44 Biotin Hu C, F, P
0.1 mg / €360.00
  Novus Biologicals Inc.

CD218a / IL18R1 antibody

Flow Cytometry: IL-18R alpha Antibody (H44) [NB100-77941] - Human peripheral blood lymphocytes stained with H44 FITC Mouse IgG1 H44 FITC Hu F
100 Tests / €360.00
  Novus Biologicals Inc.

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