CD221 / IGF1R antibody

Principal name

CD221 / IGF1R antibody

Alternative names for CD221 / IGF1R antibody

IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor

SwissProt ID

P08069 (Human), P24062 (Rat), Q05688 (Bovin), Q29000 (Pig), Q60751 (Mouse)

Gene ID

3480 (IGF1R), 16001 (Igf1r)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of CD221 / IGF1R antibody

IGF1R(Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, Dey et al. (1998) identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.

General readings

1. Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
2. Baserga, R. et al. (2000) Oncogene 19, 5574-5581
Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
3. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17(1): 427-35.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD221 / IGF1R (alpha chain) antibody

Staining of human peripheral blood granulocytes with Mouse anti Human CD221-Low Endotoxin Cat,.-No BM2226LE (Clone 1H7). Mouse IgG1 1H7 Low Endotoxin Hu F, FN, P, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

CD221 / IGF1R (alpha chain) antibody

Staining of human peripheral blood granulocytes with mouse anti human CD221 (BM2226P) Mouse IgG1 1H7 Purified Hu F, P, WB
0.2 mg / €430.00
  Acris Antibodies GmbH

CD221 / IGF1R (alpha chain) antibody

Staining of human peripheral blood granulocytes with mouse anti human CD221 (BM2226P) Mouse IgG1 1H7 Purified Hu F, P, WB
25 µg / €180.00
  Acris Antibodies GmbH

CD221 / IGF1R (alpha chain) antibody

CD221 / IGF1R Mouse IgG1 1H7 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD221 / IGF1R (alpha chain) antibody

Staining of human peripheral blood ganulocytes with mouse anti human CD221:RPE Mouse IgG1 1H7 PE Hu F
25 Tests / €210.00
  Acris Antibodies GmbH

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1 Receptor Antibody  
Western Blot: IGF1 Receptor Antibody - WB analysis of IGFR1 in: 1. HeLa, 2. NIH/3T3, 3. SK-BR-3 and 4. COS7 Rabbit Purified Hu, Ms, Prim, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit anti-IGF1R (Phospho-Tyr1165/Tyr1166) polyclonal antibody (Phospho-specific)  
Western blot analysis using IGF-1R antibody (Lanes 1, 2 and 3) and IGF-1R (phospho-Tyr1165/Tyr1166) antibody (Lanes 4 and 5). Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit anti-IGF1R polyclonal antibody  
Western blot analysis using IGF-1R antibody (Lanes 1, 2 and 3) and IGF-1R (phospho-Tyr1161) antibody (Lanes 4 and 5). Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit polyclonal IGF1R (Ab-1346) antibody  
Western blot analysis of extracts from A549 cells, using IGF1R (Ab-1346) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit polyclonal IGF1R (Tyr1346) antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Anti-IGF1R (Phospho-Tyr1165/Tyr1166) Rabbit Polyclonal Antibody  
Predicted band size: 155 kDa . Positive control: 293 cells treated with insulin lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: 293 cells untreated with insulin lysate Lane2: 293 cells treated with insulin lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Anti-IGF1R Rabbit Polyclonal Antibody  
Predicted band size: 155 kDa . Positive control: 293 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: treated with the peptide Lane2: 293 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1R Antibody  
Western blot analysis of IGF1R expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1R Antibody  
Western blot analysis of IGF1R expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1R Antibody  
Western blot analysis of IGF1R expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1R (Tyr1161) Antibody (Phospho-specific)  
Western blot analysis of IGF1R phosphorylation expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal IGF1R (Tyr1165/Tyr1166) Antibody (Phospho-specific)  
Western blot analysis of IGF1R phosphorylation expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Rabbit Polyclonal Phospho-IGF1R (Tyr1346) Antibody (Phospho-specific)  
CD221 / IGF1R Rabbit IgG Purified Hu, Ms, Rt P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Phospho-IGF1R-Y1161 Rabbit Polyclonal Antibody  
Western blot analysis of extracts from 293 cells, using Phospho-IGF1R-Y1161 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD221 / IGF1R antibody

  Phospho-IGF1R-Y1280 Rabbit Polyclonal Antibody  
Western blot analysis of extract from 293 cells, using Phospho-IGF1R-Y1280 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

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