CD222 / IGF2R antibody

Principal name

CD222 / IGF2R antibody

Alternative names for CD222 / IGF2R antibody

CI-MPR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, CI Man-6-P receptor, M6PR, Late Endosome Marker, M6P/IGF2R, MPR 300, 300 kDa mannose 6-phosphate receptor, Mannose 6 Phosphate Receptor (Cation independent)

SwissProt ID

P08169 (Bovin), P11717 (Human), Q07113 (Mouse)

Gene ID

281849 (IGF2R), 3482, 16004 (Igf2r)

Available reactivities

Bov (Bovine), Hu (Human), Prim (Primate), Rt (Rat), Ms (Mouse), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CD222 / IGF2R antibody

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface.
In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

General readings

1. Leksa, V., et al., J. Cell Sci. 118, 4577-4586 (2005)
2. Jamieson, T. A., et al., BMC Cancer 3, 4 (2003)
3. Leksa, V., et al., J. Biol. Chem. 277, 40575-40582 (2002)
4. Brown, J., et al., EMBO J. 21, 1054-1062 (2002)
5. Mason, D., et al., Leukocyte typing VII, 482-485 (2002)
6. Killian, J.K., et al., Mol. Cell 5, 707-16 (2000)
Clone MEM-238 is used in the references 1, 3 and 6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD222 / IGF2R antibody

Intracellular staining of human peripheral blood with anti-CD222 (MEM-238) PE. Mouse IgG1 MEM-238 FITC Hu, Prim F
100 Tests / €260.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Immunohistochemistry: Mannose 6 Phosphate Receptor (Cation independent) Antibody (2G11) [TA336637] - Staining of human testis using TA336637 antibody at 1:100. Mouse IgG2a 2G11 Purified Bov, Hu, Prim, Rt C, E, F, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD222 / IGF2R (C-term) antibody

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

CD222 / IGF2R (Cation independent) antibody

Immunohistochemistry-Paraffin: Mannose 6 Phosphate Receptor (Cation independent) Antibody (EPR6599) [NBP1-95917] - Analysis of paraffin-embedded human tonsil tissue using anti-Mannose 6 Phosphate Receptor antibody. Rabbit EPR6599 Purified Hu, Ms, Rt F, ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

CD222 / IGF2R antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGF2R antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD222 / IGF2R antibody

Immunohistochemistry analysis of IGF-2R antibody (Cat.-No AP20306PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

CD222 / IGF2R Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CD222 / IGF2R pSer2409 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody AP55736PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CD222 / IGF2R pSer2409 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody AP55736PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €270.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Western blot anaylsis: SM2004A CD222 antibody staining of Jurkat (Lane 1) and Raji cells (Lane 2) Mouse IgG1 MEM-238 Azide Free Hu F, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. 
Lane 1: immunostaining with anti-CD222 (MEM-238)
Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06) Mouse IgG1 MEM-238 APC Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 (MEM-238). Lane 2: immunostaining with Isotype mouse IgG1 control (AM03095PU-N) Mouse IgG1 MEM-238 Purified Hu F
0.2 mg / €590.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 (MEM-238). Lane 2: immunostaining with Isotype mouse IgG1 control (AM03095PU-N) Mouse IgG1 MEM-238 Purified Hu, Ms, Prim F, WB
0.1 mg / €230.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. 
Lane 1: immunostaining with anti-CD222 (MEM-238)
Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06) Mouse IgG1 MEM-238 PE Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD222 / IGF2R antibody

CD222 / IGF2R Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

CD222 / IGF2R antibody

Western Blotting analysis ( non-reducing conditions ) of IGF2R in whole cell lysate of Jurkat ( human peripheral blood T cell leukemia cell line ).
Lane 1 : Immunostaining with IGF2R monoclonal antibody, clone MEM-238 ( Cat # MAB3860 ).
Lane 2 : Immunostaining with Isotype mouse IgG1 control. Mouse IgG1 MEM-238 Hu F, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD222 / IGF2R antibody

CD222 / IGF2R Mouse IgG1 MEM-238 Hu F
100 reaction / €390.00
  Abnova Taiwan Corp.

CD222 / IGF2R antibody

CD222 / IGF2R Mouse IgG1 MEM-238 Hu F
100 reaction / €390.00
  Abnova Taiwan Corp.

CD222 / IGF2R pSer2409 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €205.00
  Assay Biotech

CD222 / IGF2R pSer2409 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €310.00
  Assay Biotech

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