CD227 / Mucin-1 / MUC1 antibody

Principal name

CD227 / Mucin-1 / MUC1 antibody

Alternative names for CD227 / Mucin-1 / MUC1 antibody

MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3, Polymorphic epithelial mucin, Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelial membrane antigen, Peanut-reactive urinary mucin, Breast carcinoma-associated antigen DF3

SwissProt ID

P15941 (Human), Q02496 (Mouse), Q8WML4 (Bovin)

Gene ID

4582 (MUC1), 17829 (Muc1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Dot blot (Dot), Immunoelectron Microscopy (EM), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Luminex (LMNX)

Background of CD227 / Mucin-1 / MUC1 antibody

Mucin 1 (Muc1) is a large transmembrane glycoprotein that is overexpressed by a majority of carcinomas. High expression of MUC1 is associated with aggressive tumors, and MUC1 antigen is used as a marker to monitor disease progression in breast cancer patients. Mucin is a mucopolysaccharidic matrix, its expression is widely varied during cell differentitiaon and inflammation. The extent of Glycosylation determines essential biological functions of epithelial mucins in conditions of health and disease. The mucin MUC1 is a candidate for use in specific immunotherapy against breast cancer. Mucin also protects the covering of gut epithelium where it is protected from proteolytic digestion by extensive glycosylation on the mucin molecule (1). The quantity and quality of mucins are also affected in inflammatory bowel disease (IBD) both because of a reduction in the number of goblet cells and a decrease in the number of sugar residues per oligosaccharide side chain (2). There are several mucin phenotypes examined in the gut (mucin 1-mucin 6), the expression of these mucin in various type of minute well-differentiated type adenocarcinoma has been examined for diagnostic purposes (3). The mucin knockout mice showed significant decrease in cholesterol uptake with no effect on fatty acif absorption (4).
In breast cancer, overexpression of MUC1 suggest to contributes to cancer progression and metastasis. It has been shown that naturally occurring cancer preventative, indole-3-carbinol (I3C), inhibits the expression of MUC1 in breast cancer estrogen responsive and non-responsive cells (5). Unlike normal tissue where MUC exists as heavily glycosylated form, the disease- or tumor-associated MUC molecules are underglycosylated. Such underglycosylation of the core protein in cancer tissues exposes new epitopes on the cell surface that are unique to cancer tissues (6).
Mucins are large glycoproteins characterized by mucin domains that show little sequence conservation and that are rich in the amino acids Ser, Thr and Pro. The sequentially-repeating nature of the core protein 20 a.a. polypeptide chain on the surface of malignant cells makes it a potential target for immunotherapy.

General readings

1.Lu, W.; Hisatsune, A.; Koga, T.; Kato, K.; Kuwahara, I.; Lillehoj, E. P.; Chen, W.; Cross, A. S.; Gendler, S. J.; Gewirtz, A. T.; Kim, K. C. : Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immun. 176: 3890-3894, 2006.
2.Sood, R.; Zehnder, J. L.; Druzin, M. L.; Brown, P. O. : Gene expression patterns in human placenta. Proc. Nat. Acad. Sci. 103: 5478-5483, 2006.
3.Wei, X.; Xu, H.; Kufe, D. : MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Molec. Cell 21: 295-305, 2006.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD227 / Mucin-1 / MUC1 antibody

  MUC1 (EMA) mouse monoclonal antibody, clone OTI2F6 (formerly 2F6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MUC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800790) Mouse IgG1 OTI2F6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD227 / Mucin-1 / MUC1 (C-term) antibody

Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Ig G22-L Purified Hu P
50 µl / €470.00
  Acris Antibodies GmbH

CD227 / Mucin-1 / MUC1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer stained with CD227 / Mucin-1 / MUC1 Antibody Cat.-No AM32842PU (Clone GP1.4). Note cytoplasmic and membrane staining. Mouse IgG1 GP1.4 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD227 / Mucin-1 / MUC1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer stained with CD227 / Mucin-1 / MUC1 Antibody Cat.-No AM32842PU (Clone GP1.4). Note cytoplasmic and membrane staining. Mouse IgG1 GP1.4 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD227 / Mucin-1 / MUC1 antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer stained with CD227 / Mucin-1 / MUC1 Antibody Cat.-No AM32842PU (Clone GP1.4). Note cytoplasmic and membrane staining. Mouse IgG1 GP1.4 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD227 / Mucin-1 / MUC1 antibody

  MUC1/EMA mouse monoclonal antibody,clone UMAB57  
Immunohistochemical staining of paraffin-embedded Human normal bladder tissue and bladder cancer tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG2b UMAB57 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD227 / Mucin-1 / MUC1 antibody

  MUC1/EMA mouse monoclonal antibody,clone UMAB57  
Immunohistochemical staining of paraffin-embedded Human normal bladder tissue and bladder cancer tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG2b UMAB57 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD227 / Mucin-1 / MUC1 antibody

  Rabbit Polyclonal MUC-1 Antibody  
Western Blot: MUC1 Antibody [TA336810] - HepG2 Whole cell lysates. Rabbit Purified Bov, Eq, GP, Hu, Ms, Por, Rt C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Mouse Monoclonal anti-MUC-1 Underglycosylated Antibody  
Western Blot analysis of EMA-MCF7 cell lysate with MUC-1 antibody Mouse IgG1 SPM 493 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Mouse Monoclonal anti-MUC-1/EMA/Epithelial Membrane Antigen Antibody  
Human Breast Carcinoma stained with anti-MUC-1_EMA_Epithelial Membrane Antigen antibody. Mouse IgG1 SPM 492 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Luminex and ELISA validated purified MUC1 mouse monoclonal antibody clone (1F3, clone OTI1F3 (formerly 1F3)  
MUC1 ELISA with 1F3 Capture (TA600445) and 4A5 Detection (TA700446) Antibodies. Substrate used: Recombinant Human MUC1 (TP321390) Mouse IgG1 OTI1F3 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Luminex and ELISA validated purified MUC1 mouse monoclonal antibody clone (2A5, clone OTI2A5 (formerly 2A5)  
MUC1 ELISA with 2A5 Capture (TA600446) and 4A5 Detection (TA700446) Antibodies. Substrate used: Recombinant Human MUC1 (TP321390) Mouse IgG1 OTI2A5 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Luminex and ELISA validated purified biotinylated MUC1 mouse monoclonal antibody (clone 2E3), clone OTI2E3 (formerly 2E3)  
MUC1 ELISA with 2A5 Capture (TA600446) and 2E3 Detection (TA700445) Antibodies. Substrate used: Recombinant Human MUC1 (TP321390) Mouse IgG1 OTI2E3 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  Luminex and ELISA validated purified biotinylated MUC1 mouse monoclonal antibody (clone 4A5), clone OTI4A5 (formerly 4A5)  
MUC1 ELISA with 2A5 Capture (TA600446) and 4A5 Detection (TA700446) Antibodies. Substrate used: Recombinant Human MUC1 (TP321390) Mouse IgG1 OTI4A5 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

CD227 / Mucin-1 / MUC1 antibody

  MUC1 (EMA) mouse monoclonal antibody, Clone , clone OTIF3 (formerly F3)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MUC1 mouse monoclonal antibody. (TA800769) Dilution: 1:150 Mouse IgG1 OTIF3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD227 / Mucin-1 / MUC1 antibody

  MUC1 (EMA) mouse monoclonal antibody, clone OTI2E3 (formerly 2E3)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MUC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800794) Mouse IgG2a OTI2E3 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD227 / Mucin-1 / MUC1 antibody

  MUC1 (EMA) mouse monoclonal antibody, clone OTI4A5 (formerly 4A5)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-MUC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800838) Mouse IgG2b OTI4A5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD227 / Mucin-1 / MUC1 antibody

  MUC1 (EMA) mouse monoclonal antibody, clone OTI3A7 (formerly 3A7)  
Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-MUC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800938) Mouse IgG2a OTI3A7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD227 / Mucin-1 / MUC1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human stomach tissue (4 µm) stained with anti-CD227 antibody (DB 048) shows strong positive immunostaining of epithelial cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG G22-L Aff - Purified Hu P
0.1 ml / €220.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD227 / Mucin-1 / MUC1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human stomach tissue (4 µm) stained with anti-CD227 antibody (DB 048) shows strong positive immunostaining of epithelial cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG G22-L Aff - Purified Hu P
0.2 ml / €290.00
  DB Biotech, spol. s r.o.

Sample sizes available

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