CD243 / MDR1 antibody

Principal name

CD243 / MDR1 antibody

Alternative names for CD243 / MDR1 antibody

Multidrug resistance protein 1, P-glycoprotein 1, ABCB1, PGY1, ATP-binding cassette sub-family B member 1

SwissProt ID

P06795 (Mouse), P08183 (Human), P21448 (Crigr), P43245 (Rat)

Gene ID

5243 (ABCB1), 18669 (Abcb1b)

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Can (Canine), Ms (Mouse), Rt (Rat), Hst (Hamster), Mam (Mammalia)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of CD243 / MDR1 antibody

Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATPbinding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD243 / MDR1 antibody

Western blot analysis of extracts (15ug) from 4 different cell lines by using anti-ABCB1 monoclonal antibody (Lane 1: 293T; Lane 2: UO_31; Lane 3: HCT_115; Lane 4: Hela). Mouse IgG1 OTI2F7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801006) Mouse IgG1 OTI2C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801007) Mouse IgG2a OTI6H2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801008) Mouse IgG1 OTI2G6 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801055) Mouse IgG2a OTI5B3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806679) Mouse IgG2b OTI8A9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806689) Mouse IgG2a OTI11D2 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806702) Mouse IgG2a OTI1A7 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806730) Mouse IgG2b OTI10H3 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 (262-277) antibody

Western blot using affinity purified anti-ABCB1 antibody shows detection of ABCB1 in crude membrane extracts from HF insect cells over-expressing human ABCB1. The extract was loaded onto a gel in the amounts indicated followed by electrophoresis and transfer to nitrocellulose. The membrane was probed with the primary antibody diluted to 1:600, followed by Peroxidase Conjugated Affinity Purified Anti-RABBIT IgG at 1:10,000. Personal Communication, Anna Calcagno, CCR-NCI, Bethesda, MD. Rabbit IgG Aff - Purified Can, Hu, Mky, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD243 / MDR1 antibody

Anti-ABCB1 / MDR1 antibody IHC of human kidney, proximal convoluted tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

CD243 / MDR1 (Cytopl. Dom.) antibody

Anti-ABCB1 / MDR1 antibody IHC of human adrenal, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD243 / MDR1 antibody

SF9 cells lysate (5 ug, left lane) and SF9 cells lysate expressing human recombinant protein fragment (5 ug, right lane) corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) were separated by SDS-PAGE and immunoblotted with anti-ABCB1 Mouse IgG1 OTI2G4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

SF9 cells lysate (5 ug, left lane) and SF9 cells lysate expressing human recombinant protein fragment (5 ug, right lane) corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) were separated by SDS-PAGE and immunoblotted with anti-ABCB1 Mouse IgG1 OTI2G7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or fragment (347-710 AA) of ABCB1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ABCB1. Mouse IgG1 OTI3H7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801003) Mouse IgG1 OTI3C8 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

Mock SF9 cells lysate (5 ug, left lane) and SF9 cells lysate expressing human recombinant protein fragment (5 ug, right lane) corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) were separated by SDS-PAGE and immunoblotted with anti-ABCB1 Mouse IgG1 OTI2H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or fragment (995-1280 AA) of ABCB1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ABCB1. Mouse IgG2b OTI5F1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

SF9 cells lysate (5 ug, left lane) and SF9 cells lysate expressing human recombinant protein fragment (5 ug, right lane) corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) were separated by SDS-PAGE and immunoblotted with anti-ABCB1. Mouse IgG1 OTI4F3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD243 / MDR1 antibody

SF9 cells lysate (5 ug, left lane) and SF9 cells lysate expressing human recombinant protein fragment (5 ug, right lane) corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) were separated by SDS-PAGE and immunoblotted with anti-ABCB1 Mouse IgG1 OTI5E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Items 1 to 20 of 53 total

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