CD244 antibody

Principal name

CD244 antibody

Alternative names for CD244 antibody

NK cell type I receptor protein 2B4, NAIL, NKR2B4, Natural killer cell receptor 2B4, NK cell activation-inducing ligand

SwissProt ID

Q07763 (Mouse), Q9BZW8 (Human), Q9JLM2 (Rat)

Gene ID

51744 (CD244), 18106 (Cd244)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of CD244 antibody

Mouse CD244, also known as 2B4, is a receptor belonging to the CD2 family of proteins involved in non-MHC dependent cytotoxicity. Expression is found on tural killer (NK) cells and many NKT cells and CD8+ cells. In C57BL/6 mice, two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner through sigling through SHP-2, while the short form functions in an activating manner. The ligand for CD244 is CD48 which is expressed on all hematopoietic cells. Recent data suggests that CD244 interactions with CD48, but not CD2 interaction with CD48, is essential for IL-2??riven expansion and activation of murine NK cells.Reports show CD244 expression can discrimite hematopoietic progenitors. Hematopoietic stem cells (HSC) are highly purified as CD150+CD244-CD48- cells while non-self-renewing multipotent hematopoietic progenitors (MPP) are CD244+CD150-CD48- and the most restricted progenitors are CD48+CD244+CD150-.eBio244F4 was generated against cell lines expressing CD244. It reacts with the C57BL/6 but not Balb/c due to polymorphisms present in the immunoglobulin V domain of the protein. The epitope recognized by eBio244F4 is different from that of 2B4; therefore these antibodies do not cross-block the binding to the respective epitopes.

General readings

Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol. 1999 Jun 15;162(12):6981-5.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD244 pTyr271 antibody

(2ug/ml) staining of IP from a lysate of Human Natural Killer cells with (+) or without (-) pervanadate treatment of the cells. Primary incubation was 1 hour. Detected by chemiluminescence. Data kindly provided by Dr Nicholas G Clarkson, Sir William Dunn School of Pathology, Oxford, UK Goat Aff - Purified Hu E, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD244 (C-term) antibody

Western blot analysis of SLAMF4 in Daudi cell lysate with SLAMF4 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD244 antibody

C57BL/6 splenocytes were cultured for 6 days in Mouse IL-2 Recombinant Protein and subsequently stained with 0.125 ug of Anti-Mouse CD244.2 (2B4) Purified (filled histogram) or 0.125 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Rat eBio244F4 Purified Ms F, WB
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD244 antibody

Western blot analysis of extracts of various cell lines, using CD244 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD244 control peptide

CD244
50 µg / €160.00
  Acris Antibodies GmbH

CD244 antibody

Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD244: LOW ENDOTOXIN(SM2267LE). Mouse IgG1 2B4.69 Low Endotoxin Hu F, IP
0.5 mg / €540.00
  Acris Antibodies GmbH

CD244 antibody

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD244 (SM2267P/PS/PT). Mouse IgG1 2B4.69 Purified Hu F, IP
0.2 mg / €440.00
  Acris Antibodies GmbH

CD244 antibody

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD244 (SM2267P/PS/PT). Mouse IgG1 2B4.69 Purified Hu F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD244 antibody

CD244 Mouse IgG1 2B4.69 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD244 antibody

CD244 Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD244 antibody

CD244 Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €290.00
  Boster Immunoleader

CD244 antibody

CD244 Mouse IgG1 2B4.69 Biotin Hu F
0.1 mg / €430.00
  Novus Biologicals Inc.

CD244 antibody

CD244 Mouse IgG1 2B4.69 Purified Hu F, IP
0.1 mg / €360.00
  Novus Biologicals Inc.

CD244 antibody

CD244 Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CD244 antibody

Western Blot: CD244 Antibody [NBP1-76558] - Analysis of SLAMF4 in Daudi cell lysate with SLAMF4 antibody at (A) 1 and (B) 2 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

CD244 antibody

Immunohistochemistry-Paraffin: CD244 Antibody [NBP1-89386] - Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD244

CD244 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CD244 (transcript variant 3)

CD244 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD244 (19-224, His-tag)

CD244 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

CD244 (19-224, His-tag)

CD244 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

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