CD248 / TEM1 antibody

Principal name

CD248 / TEM1 antibody

Alternative names for CD248 / TEM1 antibody

CD164L1, Endosialin, Tumor endothelial marker 1

SwissProt ID

Q91V98 (Mouse), Q9HCU0 (Human)

Gene ID

57124 (CD248)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), EPair for Elisa (EPair), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of CD248 / TEM1 antibody

Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion. At least two isoforms of TEM1 are known to exist; this antibody recognizes only the larger isoform.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD248 / TEM1 (C-term) antibody

  Rabbit Polyclonal TEM1 Antibody  
Western blot analysis of TEM1 in human colon tissue lysate with TEM1 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD248 / TEM1 (N-term) antibody

  Rabbit Polyclonal TEM1 Antibody  
Western blot analysis of TEM1 in human colon tissue lysate with TEM1 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD248 / TEM1 antibody

  Rabbit Polyclonal Anti-CD248 Antibody  
Host: Rabbit; Target Name: Cd248; Sample Tissue: Mouse Thymus lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD248 / TEM1 antibody

  CD248 mouse monoclonal antibody, clone OTI4B8 (formerly 4B8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD248 (RC208576, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD248. Mouse IgG2b OTI4B8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD248 / TEM1 (C-term) antibody

Human Pancreas (formalin-fixed, paraffin-embedded) stained with CD248 antibody AP22609PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CD248 overexpression lysate

CD248 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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