CD25 / IL2RA antibody

Principal name

CD25 / IL2RA antibody

Alternative names for CD25 / IL2RA antibody

Interleukin-2 receptor alpha chain, IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen

SwissProt ID

O02733 (Pig), O62802 (Canfa), P01589 (Human), P01590 (Mouse), P12342 (Bovin), P26897 (Rat), P26898 (Sheep), P41690 (Felca)

Gene ID

25704 (Il2ra), 3559 (IL2RA), 16184, 443435, 281861, 9332 (CD163), 396814

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Sh (Sheep), Bov (Bovine), Mky (Monkey), Rhesus Mky (Rhesus Monkey), Por (Porcine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Neutralisation (NEUT)

Background of CD25 / IL2RA antibody

CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggerring of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. The IL2 receptor (IL2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity alpha chain of the IL2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O linked carbohydrates and has a short cytoplasmic tail. CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all mouse strains tested. It is transiently expressed at a low level during B cell development in bone marrow on the CD45R/B220 low TdT- sIg- pre-B II and CD45R/B220low TdT- sIgM+sIgD- immature B cells, but not on the CD45R/B220 low TdT+ sIg- pro-B/pre B I stage nor on CD45R/B220high TdT- sIgM+sIgD+ mature B cells. CD25 is expressed at a higher level during very early T cell development in fetal and adult thymus.

General readings

1. Lai KN, Leung JC, Lai FM: Soluble interleukin 2 receptor release, interleukin 2 production, and interleukin 2 receptor expression in activated T-lymphocytes in vitro. Pathology. 1991 Jul;23(3):224-8.
2. Scheibenbogen C, Keilholz U, Richter M, Andreesen R, Hunstein W: The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of
the alpha and beta chains (p55 and p75). Res Immunol. 1992 Jan;143(1):33-7.
3. Morris JC, Waldmann TA: Advances in interleukin 2 receptor targeted treatment. Ann Rheum Dis. 2000 Nov;59 Suppl 1:i109-14.
4. Sotlar K, Horny HP, Simonitsch I, Krokowski M, Aichberger KJ, Mayerhofer M, Printz D, Fritsch G, Valent P: CD25 indicates the neoplastic phenotype of mast cells: a novel
immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens. Am J Surg Pathol. 2004 Oct;28(10):1319-25.
5. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD25 / IL2RA (C-term) antibody


Human tonsil stained with anti-CD25 antibody
Rabbit IgG SP176 Purified Hu P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

CD25 / IL2RA (C-term) antibody


Human tonsil stained with anti-CD25 antibody
Rabbit IgG SP176 Purified Hu P, WB
1 ml / €750.00
  Acris Antibodies GmbH

CD25 / IL2RA (C-term) antibody


Human tonsil stained with anti-CD25 antibody
Rabbit IgG SP176 Purified Hu P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

Staining of PHA stimulated human PBMC with Anti-Human CD25 PE.  Appropriate isotype controls were used (open histogram).  Total viable cells were used for analysis. Mouse BC96 Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD25 / IL2RA antibody

Predicted band size: 31 kDa . Positive control: A549 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/750 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD25 / IL2RA antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using IL2RA antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD25 / IL2RA antibody

ELISA: IL2 Receptor alpha Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 NR-72 Purified Hu F, FN
0.2 mg / €760.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 IL-A111 FITC Bov, Sh F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 IL-A111 PE Bov, Sh F
100 Tests / €570.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG2a Azide Free Hu C, E, FN, WB
0.5 mg / €200.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 1TYV APC Hu F
100 Tests / €380.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 1TYV Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 1TYV FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 1TYV Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

Figure 1. Peripheral blood lymphocytes stained with PE labeled anti-CD25 antibody (AM05184RP-N). Mouse IgG1 1TYV PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 BC96 PE-Cy5 Hu, Mky F
100 TESTS/2.0ml / €430.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Mouse IgG1 K231.3B2 Purified Por C, F
0.1 mg / €330.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Rat IgM 7D4 APC Ms F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD25 / IL2RA antibody

CD25 / IL2RA Rat IgM 7D4 Biotin Ms F
0.5 mg / €340.00
  Acris Antibodies GmbH

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