CD253 / TRAIL antibody

Principal name

CD253 / TRAIL antibody

Alternative names for CD253 / TRAIL antibody

Apo-2 ligand, TNFSF10, APO2L, Apo-2L, Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand

SwissProt ID

P50591 (Human), P50592 (Mouse)

Gene ID

8743 (TNFSF10), 22035 (Tnfsf10), 10850 (CCL27)

Available reactivities

Hu (Human), Rt (Rat), Can (Canine), Por (Porcine), Ms (Mouse)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), ELISA (capture) (E(capture))

Background of CD253 / TRAIL antibody

Apoptosis or programmed cell death is induced in cells by a group of death domain-containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF-related apoptosis-induced ligand) or Apo-2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic \death domain\". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues. TRAIL (also called Apo-2 ligand) is a type II membrane protein from the TNF family. The human form of the protein is 281 amino acids in length, whereas the murine form is 291 amino acids. The two forms share 65% identity. Recombinant human TRAIL monomer has a molecular mass of approximately 21 kDa. Due to glycosylation, recombinant human TRAIL migrates as a 24 kDa protein in SDS-PAGE."""

General readings

Wajant H et al. TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis 7:449-59 (2002). PubMed PMID: 12207178
Nagane M et al. The potential of TRAIL for cancer chemotherapy. Apoptosis 6:191-7 (2001). PubMed PMID: 11388668
Phillips TA et al. TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege. J Immunol 162:6053-9 (1999). PubMed PMID: 10229846
Gura T How TRAIL kills cancer cells, but not normal cells. Science 277:768 (1997). PubMed PMID: 9273698
Pitti RM et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271:12687-90 (1996). PubMed PMID: 8663110

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD253 / TRAIL (C-term) antibody

Western blot analysis of TRAIL in HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TRAIL with TRAIL antibody at 1 ug/ml. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western blot analysis of extracts from 293 cells and HUVEC cells, using CD253 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Staining of mouse TRAIL-transfected cells with 0.5 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse CD253 (TRAIL) Purified (filled histogram) followed by F(ab')2 Anti-Rat IgG PE .  Total viable cells were used for analysis. Rat N2B2 Purified Ms F, IP
50 µg / €120.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Surface staining of human Trail transfected cells with Anti-Human CD253 (TRAIL) PE.  Appropriate isotype controls were used (open histogram).  Total viable cells were used for analysis. Mouse RIK-2 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human metastatic carcinoma of lymph node from breast tissue.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended.  Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

WB Suggested Anti-TNFSF10 Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western Blot: TRAIL Antibody (55B709.3) [TA336381] - Analysis of TRAIL in Jurkat lysate Mouse IgG1 55B709.3 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western blot analysis of CD253 expression in 293 cells Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

A typical staining pattern with the B-S23 monoclonal antibody of IFNa2+CD3 mAb+CD28 mAb activated lymphocytes Mouse IgG1 B-S23 Biotin Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Purified Hu F
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

A typical staining pattern with the B-S23 monoclonal antibody of IFNa2+CD3 mAb+CD28 mAb activated lymphocytes Mouse IgG1 B-S23 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-T24 Azide Free Hu FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-T24 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Rabbit Purified Hu E, FN, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

Western blot (WB) analysis of TRAIL antibody (Cat.-No.: AP06701PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD253 / TRAIL Control Peptide

CD253 / TRAIL
50 µg / €160.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Rabbit Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Rabbit Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

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