CD253 / TRAIL antibody

Principal name

CD253 / TRAIL antibody

Alternative names for CD253 / TRAIL antibody

Apo-2 ligand, TNFSF10, APO2L, Apo-2L, Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand

SwissProt ID

P50591 (Human), P50592 (Mouse)

Gene ID

8743 (TNFSF10), 22035 (Tnfsf10)

Available reactivities

Can (Canine), Hu (Human), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), ELISA (capture) (E(capture)), Immunoprecipitation (IP)

Background of CD253 / TRAIL antibody

In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein which functions as a ligand which induces the process of cell death called apoptosis. TRAIL has also been designated CD253 (cluster of differentiation 253).Tumor necrosis factor (TNF) family cytokines function as prominent mediators of immune regulation and the inflammatory response. Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase-8 activates downstream effector caspases including procaspase-3, -6, and -7, leading to activation of specific kinases. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). The standard product used in this kit is recombinant human TRAIL with the molecular mass of 21KDa. It is expressed from the amino acids ectoderm T95--G28.

General readings

Janssen EM, et al , (2005). Nature. Mar 3;434(7029):88-93
Nagane M , et al , (2001). Apoptosis. Jun;6(3):191-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD253 / TRAIL (C-term) antibody

Western blot analysis of TRAIL in HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TRAIL with TRAIL antibody at 1 ug/ml. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western blot analysis of extracts from 293 cells and HUVEC cells, using CD253 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Staining of mouse TRAIL-transfected cells with 0.5 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse CD253 (TRAIL) Purified (filled histogram) followed by F(ab')2 Anti-Rat IgG PE .  Total viable cells were used for analysis. Rat N2B2 Purified Ms F, IP
50 µg / €120.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Surface staining of human Trail transfected cells with Anti-Human CD253 (TRAIL) PE.  Appropriate isotype controls were used (open histogram).  Total viable cells were used for analysis. Mouse RIK-2 Purified Hu F
25 µg / €120.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human metastatic carcinoma of lymph node from breast tissue.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended.  Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

WB Suggested Anti-TNFSF10 Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western Blot: TRAIL Antibody (55B709.3) [TA336381] - Analysis of TRAIL in Jurkat lysate Mouse IgG1 55B709.3 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

Western blot analysis of CD253 expression in 293 cells Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

CD253 / TRAIL Mouse RIK-2 Purified Hu F
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

A typical staining pattern with the B-S23 monoclonal antibody of IFNa2+CD3 mAb+CD28 mAb activated lymphocytes Mouse IgG1 B-S23 Biotin Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Purified Hu F
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

A typical staining pattern with the B-S23 monoclonal antibody of IFNa2+CD3 mAb+CD28 mAb activated lymphocytes Mouse IgG1 B-S23 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-T24 Azide Free Hu FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-S23 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Mouse IgG1 B-T24 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Rabbit Purified Hu E, FN, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

Western blot (WB) analysis of TRAIL antibody (Cat.-No.: AP06701PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD253 / TRAIL Control Peptide

CD253 / TRAIL
50 µg / €160.00
  Acris Antibodies GmbH

CD253 / TRAIL antibody

CD253 / TRAIL Rabbit Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

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