CD256 / APRIL antibody

Principal name

CD256 / APRIL antibody

Alternative names for CD256 / APRIL antibody

TNFSF13, TALL2, TALL-2, ZTNF2, TRDL-1, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1

SwissProt ID

O75888 (Human), Q9D777 (Mouse)

Gene ID

8741 (TNFSF13), 69583 (Tnfsf13)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Hst (Hamster), Mky (Monkey), Por (Porcine), Prim (Primate), Bear

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP)

Background of CD256 / APRIL antibody

Tumor necrosis factor ligand superfamily member 13(TNFSF13) also known as a proliferation-inducing ligand(APRIL) is a protein that in humans is encoded by the TNFSF13 gene. TNFSF13 has also been designated CD256(cluster of differentiation 256). The protein encoded by this gene is a member of the tumor necrosis factor ligand(TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such asTNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The TNFSF13 gene lies 878 bp downstream of the TNFSF12 gene on chromosome 17p13.1.

General readings

1. Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998;188(6):1185-90.
2. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999;65(5):680-3.
3. Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000;60(4):1021-7.
4. Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1(3):252-6.
5. Wu Y, Bressette D, Carrell JA, et al. Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. J. Biol. Chem. 2000;
275:35478-85.
6. Marsters SA, Yan M, Pitti RM, et al. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 2000; 10:785-8.
7. Rennert P, Schneider P, Cachero TG, at al. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J. Exp. Med. 2000; 192:1677-84.
8. Gross JA, Johnston J, Mudri S, et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000; 404:995-9.
9. Ware CF. APRIL and BAFF connect autoimmunity and cancer. J. Exp. Med. 2000; 192:F35-8. (RD1005)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD256 / APRIL (Internal) antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with TNFSF13 antibody AP22853PU-N at 2.5 mg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD256 / APRIL (Extracell. Dom.) antibody

Human Spleen (formalin-fixed, paraffin-embedded) stained with TNFSF13 antibody AP22855PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD256 / APRIL (Extracell. Dom.) antibody

Western blot analysis of APRIL expression in K562 cells with APRIL antibody at (A) 5 and (B) 10 µg/ml. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 ug/ml (A), 2 ug/ml (B), and 4 ug/ml (C). Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

Western blot analysis of extracts from HeLa cells and COLO205 cells, using TALL-2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

This antibody stained formalin-fixed paraffin-embedded sections of human carcinoid tissue.  The recommended concentration is 0.25 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended. Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

Western blot analysis on HeLa cell lysate using TALL-2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

Western blot analysis of TALL-2 expression in COLO205 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (TNFSF13 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (TNFSF13 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD256 / APRIL antibody

CD256 / APRIL Rabbit Serum Hu E, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

CD256 / APRIL antibody

CD256 / APRIL Rabbit Serum Hu E, WB
20 µl / €170.00
  Acris Antibodies GmbH

CD256 / APRIL antibody

Immunohistochemistry analysis of CD256 / APRIL Antibody (Cat.-No AP06646PU-N) in paraffin-embedded human colon carcinoma tissue Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD256 / APRIL (1-17) antibody

Breast: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD256 / APRIL (310-323) antibody

Kidney, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Hst, Hu, Mky, Ms, Por, Prim, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

CD256 / APRIL Control Peptide

CD256 / APRIL
50 µg / €160.00
  Acris Antibodies GmbH

CD256 / APRIL Control Peptide

CD256 / APRIL
50 µg / €160.00
  Acris Antibodies GmbH

CD256 / APRIL antibody

CD256 / APRIL Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CD256 / APRIL antibody

CD256 / APRIL Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CD256 / APRIL antibody

CD256 / APRIL Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

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