CD258 / LIGHT antibody

Principal name

CD258 / LIGHT antibody

Alternative names for CD258 / LIGHT antibody

TNFSF14, HVEML, HVEM-L, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator-ligand

SwissProt ID

O43557 (Human), Q9QYH9 (Mouse)

Gene ID

8740 (TNFSF14), 50930 (Tnfsf14)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of CD258 / LIGHT antibody

LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

General readings

Cohavy O, Zhou J, Ware CF, Targan SR LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling J. Immunol. 2005 Jan 174 (2): 646-53

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD258 / LIGHT antibody

TA305766 (1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

Immunofluorescence analysis of HeLa cells, using TNF14 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

WB Suggested Anti-TNFSF14 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysate TNFSF14 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD258 / LIGHT antibody

Immunoperoxidase of monoclonal antibody to TNFSF14 on formalin-fixed paraffin-embedded human spleen. [antibody concentration 3 ug/ml] Mouse IgG2a 4E3 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD258 / LIGHT antibody

CD258 / LIGHT Mouse IgG2a 4E3 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

CD258 / LIGHT antibody

Immunofluorescence analysis of HeLa cells, using TNF14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

CD258 / LIGHT antibody

Immunofluorescence analysis of HeLa cells, using TNF14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

CD258 / LIGHT antibody

Human 721_B; WB Suggested Anti-TNFSF14 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: 721_B cell lysate. TNFSF14 is supported by BioGPS gene expression data to be expressed in 721_B.; TNFSF14 antibody - middle region (AVARP02041_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Can, Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

CD258 / LIGHT antibody

Western blot analysis of CD258 expression in HeLa (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CD258 / LIGHT antibody

Western blot analysis of CD258 expression in HeLa (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD258 / LIGHT antibody

Western blot analysis of CD258 expression in HeLa (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD258 / LIGHT antibody

CD258 / LIGHT Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF
0.1 mg / €360.00
  Novus Biologicals Inc.

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF
50 µg / €290.00
  Novus Biologicals Inc.

CD258 / LIGHT antibody

Immunohistochemistry-Paraffin: TNFSF14 Antibody [NBP1-85773] Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

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