CD258 / LIGHT antibody

Principal name

CD258 / LIGHT antibody

Alternative names for CD258 / LIGHT antibody

TNFSF14, HVEML, HVEM-L, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator-ligand

SwissProt ID

O43557 (Human), Q9QYH9 (Mouse)

Gene ID

50930 (Tnfsf14), 8740 (TNFSF14)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of CD258 / LIGHT antibody

TNFSF14 is the cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B TNFSF14 modulates its effects. TNFSF14 activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. TNFSF14 acts as a receptor for Herpes simplex virus.The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two altertively spliced transcript variant encoding distinct isoforms have been reported.

General readings

Cohavy O, Zhou J, Ware CF, Targan SR LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling J. Immunol. 2005 Jan 174 (2): 646-53

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD258 / LIGHT antibody

  Goat Anti-LIGHT / CD258 Antibody  
TA305766 (1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

  Rabbit polyclonal anti-TNF14 antibody  
Immunofluorescence analysis of HeLa cells, using TNF14 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

  Rabbit Polyclonal Anti-TNFSF14 Antibody  
WB Suggested Anti-TNFSF14 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysate TNFSF14 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

CD258 / LIGHT Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD258 / LIGHT antibody

Immunofluorescence analysis of HeLa cells, using TNF14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €230.00
  Assay Biotech

CD258 / LIGHT antibody

Immunofluorescence analysis of HeLa cells, using TNF14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TNFSF14 - human gene knockout kit via CRISPR

TNFSF14 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tnfsf14 - mouse gene knockout kit via CRISPR

Tnfsf14 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tnfsf14 - mouse gene knockout kit via CRISPR

Tnfsf14 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfsf14 - mouse gene knockout kit via CRISPR

Tnfsf14 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfsf14 - mouse gene knockout kit via CRISPR

Tnfsf14 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD258 / LIGHT (transcript variant 1)

  Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1  
CD258 / LIGHT Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD258 / LIGHT (transcript variant 1)

  Purified recombinant protein of Human tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1.  
CD258 / LIGHT Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.

Regular Price: 15 µg / €199.00

Special Price: 15 µg / €139.00

  OriGene Technologies, Inc.

CD258 / LIGHT

  Purified recombinant protein of Mouse tumor necrosis factor (ligand) superfamily, member 14 (Tnfsf14).  
CD258 / LIGHT Mouse > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 20 µg / €199.00

Special Price: 20 µg / €139.00

  OriGene Technologies, Inc.

ELISA Kits

Catalog No.    

Human TNFSF14/LIGHT ELISA Kit

Human TNFSF14/LIGHT ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TNFSF14 overexpression lysate

TNFSF14 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TNFSF14 (mGFP-tagged) - Human tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TNFSF14 (mGFP-tagged) - Human tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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