CD26 / DPP4 antibody

Principal name

CD26 / DPP4 antibody

Alternative names for CD26 / DPP4 antibody

ADCP2, Dipeptidyl peptidase 4, DPP IV, Dipeptidyl peptidase IV, ADABP, TP103, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2

SwissProt ID

P14740 (Rat), P22411 (Pig), P27487 (Human), P28843 (Mouse), P81425 (Bovin), Q9N2I7 (Felca)

Gene ID

1803 (DPP4), 13482 (Dpp4), 25253, 281122

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Hst (Hamster), Can (Canine), Fe (Feline), Por (Porcine), Sh (Sheep), Gt (Goat), Eq (Equine), Mky (Monkey)

Available hosts

Mouse, Rat, Rabbit, Chicken, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Functional assay (FN)

Background of CD26 / DPP4 antibody

D26, a T cell activation antigen, is a 110kDa cell surface glycoprotein with known dipeptidyl peptidase IV activity in its extracellular domain which is present on various cell types, including T cells and epithelial cells of the liver, kidney, and intestine. Of the T cell antigens described to date, CD26 has proved to be one of the most intriguing in the scope of its functional associations. Considerable evidence suggests that CD26 can deliver a potent costimulatory signal to T-cells. This signal transducing property appears to be a property of its extracellular domain. In addition, CD26 appears to be a functional collagen receptor that may aid activated T-cells in localizing to inflammatory regions. It has also been demonstrated that CD26 not only acts as a functional dipeptidyl peptidase IV, but also binds strongly to adenosine deaminase. Significant levels of DPPIV activity have been shown to exist in plasma, serum, and urine. The serum form of DPPIV is unique, and is not a breakdown product of membrane CD26, nevertheless exposing significant structural similarity to the membrane form.

General readings

1. Kishimoto T. et al., eds. Leukocyte Typing VI, p478-489 and p1128, Garland Publishing, Inc, New York and London, 1997.
2. Fleischer B. Immunol Today 1994, 15:180-184.
3. Abbott CA. et. al. Immunogenetics 1994, 40:331-338.
4. Valenzuela A et. al. Adv Exp Med Biol 1997, 421:185-192.
5. Cheng HC, et al. J Biol Chem. 1998 273(37):24207-24015.
6. Morimoto C and Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev 1998, 161:55.
7. Fleischer B. CD26: a surface protease involved in T-cell activation. Immunol Today 1994 15:180.
8. Tanaka T, et al. Cloning and functional expression of the T cell activation antigen CD26. J Immunol 1992, 149:481.
9. Hegen M, et al. Function of dipeptidyl peptidase IV (CD26, Tp103) in transfected human T cells. Cell Immunol 1993, 146:249.
10. Bohm SK, et al. Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter. Biochem J 1995,
311:835.
11. Kameoka J, et al. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science 1993 261:466.
12. Bauvois B A. Collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV. Biochem J 1988, 252:723.
13. Torimoto Y, et al. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 1991 147:2514.
14. Oravecz T, et al. CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line. Nat Med 1995, 1:919.
15. Dong RP, et al. Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. J Immunol 1996 156:1349.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD26 / DPP4 antibody

Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-DPP4mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500733, Dilution 1:50) Mouse IgG1 OTI11D7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD26 / DPP4 antibody

TA303245 (0.3µg/ml) staining of Rat Lung lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
20 µg / €200.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

TA303245 (0.3µg/ml) staining of Rat Lung lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Staining of normal human peripheral blood cells with Anti-Human CD26 FITC (left) and PE (right).  Appropriate isotype controls were used (open histogram).  Cells in the lymphocyte population were used for analysis. Mouse 2A6 Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Eq, Hu, Por, Sh
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 (N-term) antibody

Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Eq, Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

Anti-DPP4 / CD26 antibody IHC of human small intestine, crypt. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5 ug/ml. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG1 EUG-6 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG1 EUG-6 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG1 EUG-6 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgM 134-2C2 FITC Hu F
100 Tests / €280.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgM 134-2C2 Purified Hu C, F, FN, IP
0.1 mg / €180.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgM 134-2C2 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG2a BA5b APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG2a BA5b FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG2a BA5b Aff - Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD26 / DPP4 antibody

CD26 / DPP4 Mouse IgG2a BA5b PE F
100 Tests / €290.00
  Acris Antibodies GmbH

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