CD266 / TweakR antibody

Principal name

CD266 / TweakR antibody

Alternative names for CD266 / TweakR antibody

FGF-inducible 14, FN14, TNFRSF12A, Tweak receptor, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14

SwissProt ID

Q9CR75 (Mouse), Q9NP84 (Human)

Gene ID

51330 (TNFRSF12A), 27279 (Tnfrsf12a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Functional assay (FN), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of CD266 / TweakR antibody

The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mR expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.The ITEM-4 antibody has been show to have blocking function.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD266 / TweakR antibody

  Rabbit Polyclonal Fn14 Antibody  
Western blot analysis of Fn14 in (A) mock- and (B) Fn14-GPI-transfected 293 cells with Fn14 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD266 / TweakR antibody

  Mouse Anti-Human CD266 (TWEAK Receptor) Purified (25 ug)  
Staining of non-transfected (left) and human Fn14 transfected (right) L5178Y cells with 1.0 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD266 (TWEAK Receptor) Purified (filled histogram) followed by Anti-Mouse IgG FITC . Total viable cells were analyzed. Mouse ITEM-1 Purified Hu F, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD266 / TweakR antibody

  Mouse Anti-Human/Mouse CD266 (TWEAK Receptor) Purified (25 ug)  
Staining of non-transfected (left) and human Fn14 transfected (right) L5178Y cells with 0.5 ug of Mouse IgG2a K Isotype Control Purified (open histogram) or 0.5 ug Anti-Human/Mouse CD266 (TWEAK Receptor) Purified (filled histogram) followed byAnti-Mouse IgG FITC . Total viable cells were analyzed. Mouse ITEM-4 Purified Hu, Ms F, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

CD266 / TweakR antibody

  Anti-TNFRSF12A Rabbit Polyclonal Antibody  
Predicted band size: 14 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD266 / TweakR antibody

  Anti-TNFRSF12A Rabbit Polyclonal Antibody  
Predicted band size: 14 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD266 / TweakR antibody

CD266 / TweakR Mouse IgG2b ITEM-4 Low Endotoxin Hu, Ms C, F, FN, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD266 / TweakR antibody

CD266 / TweakR Mouse IgG2b ITEM-4 Purified Hu, Ms C, F, FN, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD266 / TweakR antibody

CD266 / TweakR Mouse IgG2b ITEM-4 PE Hu, Ms F
0.1 mg / €290.00
  Acris Antibodies GmbH

CD266 / TweakR antibody

Figure 2. AP07793PU-N TweakR antibody staining of Formalin-Fixed Paraffin-Embedded Placenta tissue. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNFRSF12A - human gene knockout kit via CRISPR

TNFRSF12A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNFRSF12A - human gene knockout kit via CRISPR

TNFRSF12A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF12A - human gene knockout kit via CRISPR

TNFRSF12A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF12A - human gene knockout kit via CRISPR

TNFRSF12A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD266 / TweakR

  Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)  
CD266 / TweakR Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

CD266 / TweakR (transcript variant 2)

  Purified recombinant protein of Mouse tumor necrosis factor receptor superfamily, member 12a (Tnfrsf12a), transcript variant 2  
CD266 / TweakR Mouse > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

CD266 / TweakR

  Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A).  
CD266 / TweakR Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 25 µg / €199.00

Special Price: 25 µg / €139.00

  OriGene Technologies, Inc.

CD266 / TweakR

CD266 / TweakR Human ≥ 98 pure by SDS-PAGE and HPLC analyses. E. coli
5 µg / €140.00
  Acris Antibodies GmbH

CD266 / TweakR

CD266 / TweakR Human ≥ 98 pure by SDS-PAGE and HPLC analyses. E. coli
25 µg / €230.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

TNFRSF12A overexpression lysate

TNFRSF12A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TNFRSF12A (mGFP-tagged) - Human tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A), 200 uL, >10^7 TU/mL

Lenti ORF particles, TNFRSF12A (mGFP-tagged) - Human tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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