CD268 / BAFFR antibody

Principal name

CD268 / BAFFR antibody

Alternative names for CD268 / BAFFR antibody

BAFF receptor, BLyS receptor 3, TNFRSF13C, BR3, BAFF-R, Tumor necrosis factor receptor superfamily member 13C, B cell-activating factor receptor

SwissProt ID

Q96RJ3 (Human), Q9D8D0 (Mouse)

Gene ID

115650 (TNFRSF13C), 72049 (Tnfrsf13c)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E)

Background of CD268 / BAFFR antibody

Members of the TNF superfamily regulate immune responses and induce apoptosis. BAFF-R (B cell activating factor receptor) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kappaB and c-jun N terminal kinase.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD268 / BAFFR (C-term) antibody

Immunohistochemical staining of human tonsil with Rabbit anti CD286 (SP2134P) Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €330.00
  OriGene Technologies GmbH

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