CD269 / BCMA antibody

Principal name

CD269 / BCMA antibody

Alternative names for CD269 / BCMA antibody

TNFRSF17, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein

SwissProt ID

O88472 (Mouse), Q02223 (Human)

Gene ID

608 (TNFRSF17), 21935 (Tnfrsf17)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), EPair for Elisa (EPair)

Background of CD269 / BCMA antibody

BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain.
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

General readings

Chae S C., et al. (2010) Mol Cells. 29(1): 21-8Barone F., et al. (2009) Mucosal Immunol. 2(6): 495-503.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD269 / BCMA antibody

  Rabbit Polyclonal BCMA Antibody  
Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with BCMA antibody at 5 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD269 / BCMA antibody

  Rabbit polyclonal anti-TNFRSF17 antibody  
Western blot analysis of extracts from K562 cells and JK cells, using TNFRSF17 Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD269 / BCMA antibody

  Rabbit Polyclonal Anti-TNFRSF17 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Mouse skeletal muscle tissue, Primary antibody: (TNFRSF17 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD269 / BCMA antibody

Western blot analysis of BCMA expression in K562 (Lane 1) and U937 (Lane 2) cell lysate. Rabbit Aff - Purified Hu P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD269 / BCMA (C-term) antibody

Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu C, E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD269 / BCMA (Center) antibody

TNFRSF17 Antibody (Center) (AP54310PU-N) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the TNFRSF17 antibody detected the TNFRSF17 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNFRSF17 - human gene knockout kit via CRISPR

TNFRSF17 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNFRSF17 - human gene knockout kit via CRISPR

TNFRSF17 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF17 - human gene knockout kit via CRISPR

TNFRSF17 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF17 - human gene knockout kit via CRISPR

TNFRSF17 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf17 - mouse gene knockout kit via CRISPR

Tnfrsf17 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tnfrsf17 - mouse gene knockout kit via CRISPR

Tnfrsf17 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf17 - mouse gene knockout kit via CRISPR

Tnfrsf17 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf17 - mouse gene knockout kit via CRISPR

Tnfrsf17 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD269 / BCMA

  Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 17 (TNFRSF17).  
CD269 / BCMA Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 20 µg / €199.00

Special Price: 20 µg / €139.00

  OriGene Technologies, Inc.

CD269 / BCMA (78-184, His-tag)

CD269 / BCMA Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

CD269 / BCMA (78-184, His-tag)

CD269 / BCMA Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

CD269 / BCMA

CD269 / BCMA Human Purified > 98 % pure by SDS-PAGE and HPLC analyses E. coli
5 µg / €140.00
  Acris Antibodies GmbH

CD269 / BCMA

CD269 / BCMA Human Purified > 98 % pure by SDS-PAGE and HPLC analyses E. coli
20 µg / €230.00
  Acris Antibodies GmbH

ELISA Kits

Catalog No.    

Human TNFRSF17/BCMA ELISA Kit

Human TNFRSF17/BCMA ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

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