CD27 antibody

Principal name

CD27 antibody

Alternative names for CD27 antibody

TNFRSF7, CD27L receptor, T14, Tumor necrosis factor receptor superfamily member 7, T-cell activation antigen CD27

SwissProt ID

P26842 (Human), P41272 (Mouse)

Gene ID

939 (CD27), 21940 (Cd27)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Human, Hamster, Rat

Available applications

Flow Cytometry (F), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), Frozen Sections (C), Functional assay (FN), Neutralisation (NEUT)

Background of CD27 antibody

CD27 (Cluster of Differentiation 247) is a tumor necrosis factor receptor. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
The immune system has several effector mechanisms at its disposal to free the host of pathogens. Because these effector mechanisms can also damage the host, immune responses should be tightly controlled.
TNFR family members and their respective TNF related ligands have been implicated in the regulation of survival, proliferation, differentiation, and migration during adaptive immune responses. CD27 is a lymphoid cell-specific member of the TNFR family. Human and murine T, B, and NK cells can express CD27 In humans, CD27 expression distinguishes between naive and effector/memory stages of peripheral B and T lymphocytes.
On B cells, CD27 is only found after B cell receptor-induced activation. CD27-expressing B cells found in human peripheral blood all have undergone somatic hypermutation and therefore CD27 is considered a marker for memory B cells in humans. Resting T cells constitutively express CD27, while differentiation into effector T cells is accompanied by loss of CD27 expression.

General readings

1. van Oers MH, Pals ST, Evers LM, van der Schoot CE, Koopman G, Bonfrer JM, Hintzen RQ, von dem Borne AE, van Lier RA: Expression and release of CD27 in human B-cell
malignancies. Blood. 1993 Dec 1;82(11):3430-6.
2. Molica S, Vitelli G, Levato D, Crispino G, Dell'Olio M, Dattilo A, Matera R, Gandolfo GM, Musto P. CD27 in B-cell chronic lymphocytic leukemia. Cellular expression, serum release and correlation with other soluble molecules belonging to nerve growth factor receptors (NGFr) superfamily. Haematologica. 1998 May;83(5):398-402.
3. Kara IO, Sahin B, Gunesacar R: Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. Adv
Ther. 2007 Jan-Feb;24(1):29-40.
4. Yun LW, Decarlo AA, Hunter N: Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis. Clin Exp Immunol. 2007 Nov;150(2):217-29.
5. Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD27 antibody

Staining of BALB/c splenocytes with Anti-Human/Mouse CD45R (B220) FITC  and 0.125 ug Anti-CD27 Purified followed by Anti-Armenian Hamster IgG PE . Total viable cells were analyzed. Hamster LG.3A10 Purified Hu, Ms F, IP, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD27 antibody

Staining of mouse splenocytes with 0.25 ug Hamster IgG Isotype Control Purified (open histogram) or 0.25 ug Anti-CD27 Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC . Total viable cells were used for analysis. Hamster LG.7F9 Purified Hu, Ms, Rt F, IP
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD27 antibody

Staining of normal human peripheral blood cells with Anti-Human CD27 PE (left) and APC (right).  Appropriate isotype controls were used (open histogram).  Cells in the lymphocyte population were used for analysis. Mouse O323 Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD27 antibody

Western blot analysis of extracts of various cell lines, using CD27 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD27 (161-175) antibody

TA334178 (0.3µg/ml) staining of Human Spleen (A), Tonsil (B) and Thymus (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD27 antibody

CD27 Mouse IgG1 DEN-3 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Mouse IgG1 DEN-3 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Mouse IgG1 DEN-3 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Hamster IgG1 LG.3A10 Azide Free Ms C, F, FN, P
1.0 mg / €660.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Hamster IgG1 LG.3A10 Biotin Ms C, F, FN
0.1 mg / €240.00
  Acris Antibodies GmbH

CD27 antibody

Flow Cytometry: Balb/c Thymocytes labelled with AM31861RP-N including isotypic control. 
Percentage of cells stained above control: 90% Hamster IgG1 LG.3A10 FITC Ms C, F, FN, P
0.1 mg / €250.00
  Acris Antibodies GmbH

CD27 antibody

Flow Cytometry: Balb/c Thymocytes labelled with AM31861RP-N including isotypic control. 
Percentage of cells stained above control: 90% Hamster IgG1 LG.3A10 Purified Ms C, F, FN, P
0.25 mg / €330.00
  Acris Antibodies GmbH

CD27 antibody

Flow Cytometry: Balb/c thymocytes labelled with AM31861RP-N including isotypic control.
Percentage of cells stained above control: 90% Hamster IgG1 LG.3A10 PE Ms C, F, FN
50 µg / €250.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Mouse IgG2a CLB-27 Purified Hu ICC/IF
1 ml / €480.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Hamster IgG LG.8A6 Purified Ms E, F, IP
0.1 mg / €320.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Mouse IgG2a LT27 Azide Free Hu F
1 mg / €810.00
  Acris Antibodies GmbH

CD27 antibody

Surface staining of human peripheral blood cells with anti-human CD27 (LT27) PE. Mouse IgG2a LT27 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD27 antibody

Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD27:FITC Mouse IgG2a LT27 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD27 antibody

CD27 Mouse IgG2a LT27 Purified Hu F, IP
200 Tests / €430.00
  Acris Antibodies GmbH

CD27 antibody

Surface staining of human peripheral blood cells with anti-human CD27 (LT27) PE. Mouse IgG2a LT27 Purified Hu F
0.1 mg / €210.00
  Acris Antibodies GmbH

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