CD272 / BTLA antibody

Principal name

CD272 / BTLA antibody

Alternative names for CD272 / BTLA antibody

B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

SwissProt ID

Q6PNM1 (Rat), Q7TSA3 (Mouse), Q7Z6A9 (Human)

Gene ID

151888 (BTLA), 208154 (Btla)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Mouse, Goat, Rabbit, Hamster, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD272 / BTLA antibody

B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

General readings

Lasaro MO, Tatsis N, Hensley SE, Whitbeck JC, Lin SW, Rux JJ, Wherry EJ, Cohen GH, Eisenberg RJ, Ertl HC.
Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses.
Nat Med. 2008 Feb;14(2):205-12. Epub 2008 Jan 13.
PMID: 18193057

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD272 / BTLA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-BTLA mouse monoclonal antibody. (UM500052; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB61 Purified Can, Hu, Mky, Ms, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD272 / BTLA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-BTLA mouse monoclonal antibody. (UM500052; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB61 Purified Can, Hu, Mky, Ms, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD272 / BTLA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-BTLA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505547) Mouse IgG2b OTI4C2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

Anti-BTLA mouse monoclonal antibody (TA505558) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BTLA(RC219458). Mouse IgG2b OTI2G2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-BTLA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505688) Mouse IgG2a OTIE4 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA (C-term) antibody

TA305899 (1ug/ml) staining of Mouse Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD272 / BTLA antibody

CD272 antibody detects BTLA protein by Western blot analysis. A. 30 ug A375 whole cell lysate/extract. 10 % SDS-PAGE. CD272 antibody (TA308519) dilution: 1:1000 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD272 / BTLA antibody

Western blot analysis of extracts from K562/Jurkat cells, using BTLA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD272 / BTLA antibody

Western blot analysis of BTLA in Jurkat cell  lysate at (A) 1 and (B) 2 ug/ml. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD272 / BTLA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTLA (RC219458, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTLA. Mouse IgG1 OTI1B4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTLA (RC219458, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTLA. Mouse IgG1 OTI1E5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-BTLA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505536) Mouse IgG2b OTI4D6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTLA (RC219458, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTLA. Mouse IgG2b OTI3E10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTLA (RC219458, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTLA. Mouse IgG2b OTI2F5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

Anti-BTLA mouse monoclonal antibody (TA505687) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BTLA(RC219458). Mouse IgG2b OTI3D11 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTLA (RC219458, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTLA. Mouse IgG2a OTIG8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD272 / BTLA antibody

Staining of Human peripheral blood lymphocytes with  CD272 / BTLA antibody (cat.no. AM05617PU-L) Mouse IgG2a MIH26 Purified Hu C, F
0.2 mg / €480.00
  Acris Antibodies GmbH

CD272 / BTLA antibody

Staining of Human peripheral blood lymphocytes with  CD272 / BTLA antibody (cat.no. AM05617PU-L) Mouse IgG2a MIH26 Purified Hu C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD272 / BTLA antibody

CD272 / BTLA Mouse IgG2a 4C5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD272 / BTLA antibody

CD272 / BTLA Mouse IgG2a 1B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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