CD273 / PDL2 antibody

Principal name

CD273 / PDL2 antibody

Alternative names for CD273 / PDL2 antibody

PD-L2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1LG2, B7DC, PDCD1L2, Programmed cell death 1 ligand 2, Programmed death ligand 2

SwissProt ID

Q9BQ51 (Human), Q9WUL5 (Mouse)

Gene ID

58205 (Pdcd1lg2), 80380 (PDCD1LG2)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Functional assay (FN)

Background of CD273 / PDL2 antibody

The 122 monoclol antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No. 14-5986), another mAb specific for mouse B7-DC.

General readings

Ellis, J.S., et al. J. Immunol. 185(6):3149-3157(2010)
Pena-Cruz, V., et al. J. Invest. Dermatol. 130(9):2222-2230(2010)
Ghiotto, M., et al. Int. Immunol. 22(8):651-660(2010)
Ishizaki, Y., et al. Hum. Genet. (2010) In press.
Kassel, R., et al. Hepatology 50(5):1625-1637(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PDCD1LG2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808977)(1:150) Dilution: 1: Mouse IgG1 OTI5E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-PDCD1LG2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808982)(1:150) Mouse IgG1 OTI12C7 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-PDCD1LG2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808983)(1:150) Mouse IgG1 OTI6C3 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-PDCD1LG2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808990)(1:150) Dilu Mouse IgG1 OTI7B10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Western blot analysis of PDL-2 in Raji cell lysate with PDL-2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD273 / PDL2 antibody

CD273 / PDL2 Rat 122 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD273 / PDL2 antibody

Staining of B7-DC transfected cells with Anti-Mouse CD273 (B7-DC) PE.  Appropriate isotype controls were used  (open histogram).  Total viable cells were used for analysis. Rat TY25 Purified Ms F, IP, P, WB
50 µg / €120.00
  OriGene Technologies, Inc.

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2. Mouse IgG1 OTI10G2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2. Mouse IgG1 OTI8A4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2. Mouse IgG1 OTI11F9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PDCD1LG2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806581) Mouse IgG1 OTI8G8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2. Mouse IgG1 OTI1C9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2.(1:500) Mouse IgG1 OTI6H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PDCD1LG2 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808997)(1:150) Mouse IgG1 OTI5A7 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (RC224141, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2.(1:2000) Mouse IgG1 OTI2E7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD273 / PDL2 antibody

CD273 / PDL2 Rat IgG2a TY25 FITC Ms F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD273 / PDL2 antibody

CD273 / PDL2 Rat IgG2a TY25 Purified Ms C, F, IP
0.25 mg / €400.00
  Acris Antibodies GmbH

CD273 / PDL2 antibody

Staining of human peripheral blood monocytes with MOUSE ANTI HUMAN CD273:FITC AM05616FC-N). Mouse IgG1 MIH14 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD273 / PDL2 antibody

CD273 / PDL2 Mouse IgG1 MIH14 Purified Hu C, F
0.2 mg / €480.00
  Acris Antibodies GmbH

CD273 / PDL2 antibody

CD273 / PDL2 Mouse IgG1 MIH14 Purified Hu C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

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