CD278 / ICOS antibody

Principal name

CD278 / ICOS antibody

Alternative names for CD278 / ICOS antibody

AILIM, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule

SwissProt ID

Q58DF9 (Bovin), Q7YR73 (Canfa), Q9R1T7 (Rat), Q9WVS0 (Mouse), Q9Y6W8 (Human)

Gene ID

29851 (ICOS), 54167 (Icos), 64545

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit, Mouse, Rat, Hamster

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP)

Background of CD278 / ICOS antibody

The ISA-3 monoclol antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (cat. 14-9949), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948 or 12-9948 rather than 11-9948.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD278 / ICOS antibody

  Rat Anti-Mouse CD278 (ICOS) Purified (50 ug)  
Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control Purified (open histogram) or 0.06 ug of Anti-Mouse CD278 (ICOS) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Total viable cells were used for analysis. Rat 7E.17G9 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

  Mouse Anti-Human CD278 (ICOS) Purified (25 ug)  
Staining of CD3 + CD28 stimulated human PBMC with Anti-Human CD278 (ICOS) FITC (left), and Anti-Human CD278 (ICOS) PE (right).  Appropriate isotype controls were used (open histogram).  Total viable cells were used for analysis Mouse ISA-3 Purified Hu F, IP, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

  Anti-ICOS Rabbit Polyclonal Antibody  
Predicted cell location: Cell membrane, Cytoplasm . Positive control: Human tonsil tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ICOS antibody at dilution 1/17, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

  ICOS Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ICOS antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

  Hamster Monoclonal anti-CD278 (ICOS) Antibody  
PHA-stimulated human peripheral blood lymphocytes (3 days) stained with purified C398.4A, followed by biotinylated anti-Armenian hamster IgG and Sav-PE Hamster IgG C398.4A Purified Hu, Ms, Rt F, IP, P
0.5 mg / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

  Rabbit Polyclonal anti-CD278/ICOS Antibody  
CD278 / ICOS Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS (171-186) antibody

Figure 1. AP07922PU-N CD278/ICOS antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ICOS - human gene knockout kit via CRISPR

ICOS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ICOS - human gene knockout kit via CRISPR

ICOS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ICOS - human gene knockout kit via CRISPR

ICOS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ICOS - human gene knockout kit via CRISPR

ICOS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Icos - mouse gene knockout kit via CRISPR

Icos - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Icos - mouse gene knockout kit via CRISPR

Icos - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Icos - mouse gene knockout kit via CRISPR

Icos - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Icos - mouse gene knockout kit via CRISPR

Icos - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD278 / ICOS

  Purified recombinant protein of Human inducible T-cell co-stimulator (ICOS)  
CD278 / ICOS Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Icos (GFP-tagged) - Mouse inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL

Lenti ORF particles, Icos (GFP-tagged) - Mouse inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Icos (Myc-DDK-tagged) - Mouse inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL

Lenti ORF particles, Icos (Myc-DDK-tagged) - Mouse inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Icos (GFP-tagged ORF) - Rat inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL

Lenti ORF particles, Icos (GFP-tagged ORF) - Rat inducible T-cell co-stimulator (Icos), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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