CD278 / ICOS antibody

Principal name

CD278 / ICOS antibody

Alternative names for CD278 / ICOS antibody

AILIM, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule

SwissProt ID

Q58DF9 (Bovin), Q7YR73 (Canfa), Q9R1T7 (Rat), Q9WVS0 (Mouse), Q9Y6W8 (Human)

Gene ID

29851 (ICOS), 54167 (Icos)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Hamster, Rabbit, Mouse, Rat, Goat

Available applications

Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Functional assay (FN)

Background of CD278 / ICOS antibody

The ISA-3 monoclol antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (cat. 14-9949), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948 or 12-9948 rather than 11-9948.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD278 / ICOS (C-term) antibody

Human reactive lymph node stained with anti-CD278 antibody AM20270PU Rabbit IgG SP98 Purified Hu, Rt P
0.5 ml / €510.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Human reactive lymph node stained with anti-CD278 antibody AM20270PU Rabbit IgG SP98 Purified Hu, Rt P
1 ml / €730.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Human reactive lymph node stained with anti-CD278 antibody AM20270PU Rabbit IgG SP98 Purified Hu, Rt P
0.1 ml / €290.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

AP23811PU CD278 antibody staining of Human Tonsil. Rabbit IgG Aff - Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

AP23811PU CD278 antibody staining of Human Tonsil. Rabbit IgG Aff - Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

AP23811PU CD278 antibody staining of Human Tonsil. Rabbit IgG Aff - Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control Purified (open histogram) or 0.06 ug of Anti-Mouse CD278 (ICOS) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Total viable cells were used for analysis. Rat 7E.17G9 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

Staining of CD3 + CD28 stimulated human PBMC with Anti-Human CD278 (ICOS) FITC (left), and Anti-Human CD278 (ICOS) PE (right).  Appropriate isotype controls were used (open histogram).  Total viable cells were used for analysis Mouse ISA-3 Purified Hu F, IP, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

Predicted cell location: Cell membrane, Cytoplasm . Positive control: Human tonsil tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ICOS antibody at dilution 1/17, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS antibody

Western blot analysis of extracts of various cell lines, using ICOS antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD278 / ICOS (171-186) antibody

Figure 1. AP07922PU-N CD278/ICOS antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

Western Blot analysis of ICOS expression in transfected 293T cell line (H00029851-T02) by ICOS MaxPab polyclonal antibody.

Lane 1: ICOS transfected lysate(22.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD278 / ICOS antibody

CD278 / ICOS Mouse IgG2b 1G1 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

CD278 / ICOS antibody

CD278 / ICOS Mouse IgG2a 3G4 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD278 / ICOS antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ICOS polyclonal antibody ( Cat # PAB4726 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CD278 / ICOS antibody

ConA-stimulated Balb/c mouse splenocytes stained with biotinylated 15F9, followed by Sav-PE Hamster IgG 15F9 Biotin Ms F
0.5 mg / €800.00
  Novus Biologicals Inc.

CD278 / ICOS antibody

PHA-stimulated human peripheral blood lymphocytes (3 days) stained with purified C398.4A, followed by biotinylated anti-Armenian hamster IgG and Sav-PE Hamster IgG C398.4A Aff - Purified Hu, Ms, Rt C, F, IP, P
0.5 mg / €420.00
  Novus Biologicals Inc.

CD278 / ICOS antibody

PHA-stimulated human peripheral blood lymphocytes (3 days) stained with C398.4A FITC Hamster IgG C398.4A FITC Hu, Ms, Rt F
0.1 mg / €330.00
  Novus Biologicals Inc.

CD278 / ICOS antibody

CD278 / ICOS Rat IgG2 AP-MAB0857 Purified Ms F
0.5 mg / €380.00
  Novus Biologicals Inc.

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