CD279 / PD1 antibody

Principal name

CD279 / PD1 antibody

Alternative names for CD279 / PD1 antibody

Protein PD-1, hPD-1, PDCD1, Programmed cell death protein 1

SwissProt ID

Q02242 (Mouse), Q15116 (Human)

Gene ID

5133 (PDCD1), 18566 (Pdcd1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Mouse, Rabbit, Rat, Goat, Hamster

Available applications

Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of CD279 / PD1 antibody

The J43 monoclol antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.

General readings

1. Schmitz J, Owyang A, Oldham E, et al. IL-33, and interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23:479-90.
2. Dinarello CA. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw. 2000; 11:483-6.
3. Brint EK, Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 2004; 5:373-9.
4. Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor
accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol. 2007; 179:2551-5.
5. Carriere V, Roussel L, Ortega N, et al. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc. Natl. Acad. Sci. USA 2007; 104:282-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800089)(1:200) Mouse IgG2a UMAB197 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB198  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800090)(1:1200) Mouse IgG2a UMAB198 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB199  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110°C for 10 min, UM800091)(1:1200) Mouse IgG2a UMAB199 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800089)(1:200) Mouse IgG2a UMAB197 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB198  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800090)(1:1200) Mouse IgG2a UMAB198 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB199  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110°C for 10 min, UM800091)(1:1200) Mouse IgG2a UMAB199 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI4F10 (formerly 4F10)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806806) Mouse IgG1 OTI4F10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI8H8 (formerly 8H8)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806808)(1:150) Mouse IgG2a OTI8H8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI8H7 (formerly 8H7)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806810) Mouse IgG2a OTI8H7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI11B2 (formerly 11B2)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806811) Mouse IgG2a OTI11B2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI12D11 (formerly 12D11)  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806813)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG2a OTI12D11 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI2F6 (formerly 2F6)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806834)(1:150) Mouse IgG1 OTI2F6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI8B1 (formerly 8B1)  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806835)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG1 OTI8B1 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI4E5 (formerly 4E5)  
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806837) Mouse IgG1 OTI4E5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI21F5  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806927)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG2a OTI21F5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI16D4  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806929)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG1 OTI16D4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14C5  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806940)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG2b OTI14C5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI14B3  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA806961)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG1 OTI14B3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI26C4  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA807098)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG1 OTI26C4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD279 / PD1 antibody

  PD-1 (PDCD1) mouse monoclonal antibody, clone OTI17G9  
Immunocytochemistry staining of stable expression PD1 cells using anti-PDCD1 mouse monoclonal antibody (TA807207)(Left) . The rihgt is negative control.(1:100)(1:900) Mouse IgG1 OTI17G9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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