CD282 / TLR2 antibody

Principal name

CD282 / TLR2 antibody

Alternative names for CD282 / TLR2 antibody

Toll-like receptor 2

SwissProt ID

B2LT65 (Sheep), O60603 (Human), Q95LA9 (Bovin), Q9QUN7 (Mouse)

Gene ID

7097 (TLR2), 24088 (Tlr2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Functional assay (FN), Paraffin Sections (P), ChIP assay (ChIP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD282 / TLR2 antibody

Toll-like receptor 2 (TLR2) is a member of TLR family; it is located on human chromosome 4q32. TLR family recognizes pathogens and also plays an important role in the activation of innate immunity (1). TLR2, in association with TLR1 or TLR6, mediates innate immune responses to gram positive bacteria and yeast and a variety of conserved microbial products. TLR2 also requires MyD88 as an essential signal transducer (2). In the TLR family, TLR2 has the greatest variety of ligands; therefore, it stimulates activation of antigen presenting cells, production of pro-inflammatory cytokines, and increase in the expression of co-stimulatory ligand expression (3). The expression of TLR2 is very little to none on human endothelial cells, however, their expression increases significantly under inflammatory stimuli (4). This enables these cells to respond strongly to pathogens. TLR2 that is present on adult renal progenitor/stem cells in the kidney is also implicated in activating crucial signaling networks necessary for renal repair (5).
Toll-like receptors are also expressed on many cancer cells. It has been reported that activation of TLR2 induces cancer cell migration. TLR2 activation on cancer cells also showed significant activation of MyD88, an adaptor protein, and downstream signal transduction factors nuclear factor-kappa B and inflammatory response-related factors (6). An increase in the expression of TLR2 is also associated with neutrophil dysfunction, endotoxemia and energy depletion (7). TLR2 is highly expressed in blood leukocytes. It is approximately a 94kDa protein (784 amino acids).

General readings

1. Kajava AV, Vasselon T. A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling. J Biol Chem. 26 February 2010; 285(9):6227-6234.
2. Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta. 13 February 2002; 1589(1):1-13.
3. Wetzler LM. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine. 1 June 2003; 21(2):555-560.
4. Satta N, et al. Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides. Mol Immunol. November 2008;
46(1):145-157.
5. Sallustio F, et al. TLR2 plays a role in the activation of human resident renal stem/progenitor cells. FASEB J. February 2010; 24(2):514-525.
6. Goto Y, et al. Activation of Toll-like receptors 2, 3 and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther. November 2008; 7(11):3642-3653.
7. Stadlbauer V, et al. Role of Toll-like receptors 2, 4 and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol. January
2009; 296(1):G15-G22.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD282 / TLR2 antibody

  Rabbit Polyclonal anti-TLR2 antibody  
TLR2 antibody - C-terminal region  validated by WB using Fetal Brain Lysate at 1ug/ml. Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 (C-term) antibody

CD282 / TLR2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

CD282 / TLR2 (C-term) antibody

CD282 / TLR2 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €300.00
  SICGEN

CD282 / TLR2 (N-term) antibody

  Rabbit Polyclonal TLR2 Antibody  
Western blot analysis of TLR2 in A20 cell lysates with TLR2 antibody at 1 ug/ml in the presence (A) and absence (B) of its blocking peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Anti-Mouse CD282 (TLR2) Purified (25 ug)  
Staining of Raw246.7 cells with 0.25 ug of Mouse IgG2a kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse CD282 (TLR2) Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Mouse mT2.7 Purified Ms F, IP, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Anti-Human/Mouse CD282 (TLR2) Purified (25 ug)  
Staining of RAW264.7 cells with 0.25 ug Purified Mouse IgG  Isotype Control (open histogram) or 0.25 ug Anti-Human/Mouse CD282 (TLR2) Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Mouse T2.5 Purified Hu, Ms F, IP, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Anti-Human CD282 (TLR2) Purified (25 ug)  
Human peripheral blood monocytes were stained with Anti-Human CD282 (TLR2) Purified followed by Anti-Mouse IgG FITC . (Gated on normal peripheral monocytes) Mouse TL2.1 Purified Hu F, IP, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Anti-Human CD282 (TLR2) Purified (25 ug)  
Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG2a K Isotype Control Purified (open histogram) or 1.0 ug of Anti-Human CD282 (TLR2) Purified (filled histogram) followed by Anti-Mouse IgG FITC .  Cells in the monocyte gate were used for analysis. Mouse TL2.3 Purified Hu F, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Anti-TLR2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TLR2 antibody at dilution 1/55, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Rabbit Polyclonal TLR2 Antibody  
Western Blot: TLR2 Antibody [TA336413] - Analysis of TLR2 in (A) 15 ugs of Raw cell lysate (B) Mouse TLR2 transfected cell lysate and © Ramos cell lysate. 1 ug/ml. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Rabbit Polyclonal TLR2 Antibody  
Western Blot: TLR2 Antibody [TA336461] - analysis of TLR2 in transfected cell lysate using this antibody. Rabbit Purified Hu, Ms C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Monoclonal TLR2 Antibody (TL2.1)  
Flow Cytometry: TLR2 Antibody (TL2.1) [TA336462] - Cell surface flow analysis of TLR2 in 10^6 PBMCs using 1 ug of this antibody. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-TLR2 antibody. Mouse IgG2a TL2.1 Purified Can, Hu F, ICC/IF, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Rat Monoclonal TLR2 Antibody (11G5)  
Western Blot: TLR2 Antibody (11G5) [TA337143] - analysis of TLR2 antibody. Mouse RAW cell lysate was probed using TLR2 antibody at 5 ug/ml.  goat anti-rat Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rat IgG2a 11G5 Purified Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

  Mouse Monoclonal anti-Toll-like Receptor 2 (TLR2) Antibody  
Human peripheral blood monocytes stained with TL2.1 FITC Mouse TL2.1 Purified Hu F, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD282 / TLR2 antibody

Western blot analysis of TLR2 in Ramos cell lysate. Mouse IgG1 BV31-9 Purified Hu WB
0.1 ml / €380.00
  Acris Antibodies GmbH

CD282 / TLR2 antibody

CD282 / TLR2 Rat IgG2b 6C2 Biotin Ms F
50 µg / €290.00
  Acris Antibodies GmbH

CD282 / TLR2 antibody

CD282 / TLR2 Rat IgG2b 6C2 FITC Ms F, ICC/IF
0.1 mg / €400.00
  Acris Antibodies GmbH

CD282 / TLR2 antibody

CD282 / TLR2 Rat IgG2a 6C2 Purified Ms F, IP
0.25 mg / €500.00
  Acris Antibodies GmbH

CD282 / TLR2 antibody

CD282 / TLR2 Rat IgG2b 6C2 Purified Ms F, ICC/IF, IP
0.1 mg / €350.00
  Acris Antibodies GmbH

CD282 / TLR2 antibody

CD282 / TLR2 Rat IgG2a 6C2 Purified Ms F, IP
25 µg / €190.00
  Acris Antibodies GmbH

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