CD283 / TLR3 antibody

Principal name

CD283 / TLR3 antibody

Alternative names for CD283 / TLR3 antibody

Toll-like receptor 3

SwissProt ID

O15455 (Human), Q5TJ59 (Bovin), Q99MB1 (Mouse)

Gene ID

7098 (TLR3), 142980 (Tlr3), 7098967 (B7HEV9)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Bov (Bovine), Rt (Rat), Eq (Equine), Fe (Feline), GP (Guinea Pig), Mky (Monkey), Por (Porcine), Rb (Rabbit), Sh (Sheep), Prim (Primate)

Available hosts

Mouse, Rabbit, Goat, Rat

Available applications

Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Dot blot (Dot)

Background of CD283 / TLR3 antibody

The mammalian host defense system is essentially regulated by highly conserved Toll-like receptor (TLR) family of proteins. At least 13 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM) and caused production of inflammatory cytokines such as IL-1, IL-6, IL-8 , TNFa, and IL-12, chemokines and costimulatory molecules such as CD40, CD80 and CD86. In the presence of inflammatory cytokines and binding of adaptor molecule, MyD88 that binds FADD and triggers apoptosis through the caspase cascade. TLR induced apoptosis pathway appears to be a repatoire of defence mechanism utilized by innate defense mechanism. The constitutive expression of many human TLRs (1, 2, 4) have been shown on the surface of myeloid lineage cells by RT-PCR and use of specific monoclonal antibodies. Upon activation of these receptors by their respective chemokines and ligands have been shown in literature on various cell lines including endothelial, epithelial and other cells. The expression of TLR 3, 7, 8 and 9 are mainly found on endosomal lysosomal compartments. Human TLR3 is expressed in human fibroblasts cells and TLR 9 in in-vitro derived DC cells. There is significant evidence of TLR involvement is many systemic disorders following bacterial infection including sepsis, peridontitis, cardiac ischemia, cerebral palsy and others, understanding the TLRs involvement in these conditions will allow therapeutic interventions at the receptor level for treatment of these disorders.
So far 13 members of Toll receptors have been identified in humans (TLR1-13) for their role in pathogen recognition and activation of innate immunity. The TLR are highly conserved protein and share structural and functional domains across species. These receptors recognize [athogen associated molecular patters (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines needed for production of immediate immunity. TLR3 is a 100 kDa type I transmembrane protein characterized by extracellular domains with leucine-rich repeats and a cytoplasmic domain with type I IL-1 receptor. The TLR 2 and 4 are patter recognition receptors and signaling molecules in response to bacterial lipoproteins and is involved in innate immunity. TLR4 is expressed on peripheral blood and together with MD-2 and CD14 is responsible for LPS signaling recognition. Many specific adapter molecules (TICAM, MyD88, ICAM2, TRAM, TIRAP, TRIF etc) are also involved in signaling of several other TLRs.

General readings

1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
2. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
3. McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82.
4. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413:732-8.
5. Guillot L, Le Goffic R, Bloch S, et al. Involvement of toll-like receptor 3 in the immune response of
lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 2005; 280:5571-80.
6. Wang T, Town T, Alexopoulou L, et al. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 2004; 10:1366-73.
7. UniProtKB/Swiss-Prot entry O15455, http://www.expasy.org/uniprot/O15455, Accessed February 2, 2007.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD283 / TLR3 (C-term) antibody

Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with TLR3 antibody AP22865PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD283 / TLR3 (514-657) antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Fe, GP, Hu, Mky, Ms, Por, Rb, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 488 Can, Hu, Ms, Rt F, ICC/IF
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 488 Can, Hu, Ms, Rt F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 546 Can, Hu, Ms, Rt ICC/IF
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 546 Can, Hu, Ms, Rt ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 647 Can, Hu, Ms, Rt F
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Alexa Fluor 647 Can, Hu, Ms, Rt F
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Biotin Can, Hu, Ms, Rt WB
50 µg / €360.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Biotin Can, Hu, Ms, Rt WB
0.1 mg / €480.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Purified Can, Hu, Ms, Rt C, F, P, WB
50 µg / €330.00
  Dendritics SAS

CD283 / TLR3 antibody

IHC staining of canine skin paraffin section with clone 619F7 (DX0470) Mouse IgM 619F7.06 Purified Can, Hu, Ms, Rt C, F, P, WB
0.1 mg / €440.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 488 Can, Hu, Ms, Por, Rt, Sh F, ICC/IF
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 488 Can, Hu, Ms, Por, Rt, Sh F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 546 Can, Hu, Ms, Por, Rt, Sh ICC/IF
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 546 Can, Hu, Ms, Por, Rt, Sh ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 647 Can, Hu, Ms, Por, Rt, Sh F
50 µg / €390.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Alexa Fluor 647 Can, Hu, Ms, Por, Rt, Sh F
0.1 mg / €520.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Biotin Can, Hu, Ms, Por, Rt, Sh C, WB
50 µg / €360.00
  Dendritics SAS

CD283 / TLR3 antibody

IF staining of human tonsil frozen section with 722E2 (DDX0472) Mouse IgM 722E2.01 Biotin Can, Hu, Ms, Por, Rt, Sh C, WB
0.1 mg / €480.00
  Dendritics SAS

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