CD286 / TLR6 antibody

Principal name

CD286 / TLR6 antibody

Alternative names for CD286 / TLR6 antibody

Toll-like receptor 6

SwissProt ID

Q9EPW9 (Mouse), Q9Y2C9 (Human)

Gene ID

10333 (TLR6), 21899 (Tlr6), 1033310 (Q8FNP8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Sh (Sheep), Mky (Monkey), Fe (Feline), Por (Porcine), Prim (Primate)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Dot blot (Dot), Immunoprecipitation (IP), Functional assay (FN)

Background of CD286 / TLR6 antibody

Toll-like receptors (TLRs) are highly conserved throughout evolution. They play an essential role in initiating the innate immune response against infectious pathogens. In Drosophila, toll is required for anti-fungal response, while the related 18-wheeler is involved in antibacterial defence. In humans, ten members of the TLR family protein (TLR1 to TLR10) have been identified. TLRs recognize a wide variety of pathogen-associated molecular patterns from bacteria, viruses, and fungi and elicit a wide array of antimicrobial responses. Among TLRs, TLR6 is expressed on the cell surface of monocytes, monocyte-derived immature dendritic cells (iDCs), and neutrophils, but not on B, T or natural killer (NK) cells. Human TLR6 is a 796-aa type l transmembrane protein that is 74% identical with mouse. It contains an N-terminal signal peptide, 19 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain called Toll/IL-1R homology domain, as seen in other TLRs. TLR6 function has been studied mainly in mouse cells. Constitutive expression of TLR6 activates both the nuclear factor kappa-B (NFK-B) and Jun N-terminal kinase (JNK) pathways. Studies in human cells revealed that TLR6 and TLR2 colocalize at the plasma membrane of monocytes.

Human TLR6 recognizes diacylated lipoprotein and peptidoglycan at the cell surface cooperatively with human TLR2. Thus, coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptideoglycan and subsequent cellular activation in human cells.

General readings

Nakoa, Y et al; Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol 2005, 174: 1566.

  1. Quick-Filters:
  2. Overnight Delivery (1)

Items 1 to 20 of 49 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD286 / TLR6 (N-term) antibody

Western blot analysis of TLR6 in Jurkat cell lysate with TLR6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD286 / TLR6 (Center) antibody

Western blot analysis of TLR6 in Jurkat cell lysate with TLR6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD286 / TLR6 antibody

Staining of MEG-01 cell line with 0.25 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD286 (TLR6) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Rat hPer6 Purified Hu F, WB
25 µg / €120.00
  OriGene Technologies, Inc.

CD286 / TLR6 antibody

Immunohistochemistry-Paraffin: TLR6 Antibody (86B1153.2) [TA336394] - Tonsil probed with TLR6 antibody at 5 ug/ml. Novus's human tissue TMA  was used for this test.Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium c Mouse IgG1 86B1153.2 Purified Hu C, F, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD286 / TLR6 antibody

Western Blot: TLR6 Antibody [TA336571] - Detection of TLR6 in Jurkat whole cell extract using TA336571. Rabbit Purified Hu, Ms, Prim, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD286 / TLR6 antibody

Immunohistochemistry-Paraffin: TLR6 Antibody [TA337082] - IHC analysis of TLR6 in paraffin-embedded human breast tissue using this antibody. Rabbit Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD286 / TLR6 antibody

CD286 / TLR6 Mouse IgG2a 3B6 Purified Hu E, F
0.1 mg / €320.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

CD286 / TLR6 Mouse IgG1 TLR6.127 FITC Hu F, ICC/IF
0.1 mg / €390.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

CD286 / TLR6 Mouse IgG1 TLR6.127 Purified Hu FN, ICC/IF, IP, P
0.1 mg / €340.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

CD286 / TLR6 Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

Figure 2. Staining TLR6 in Lung, Alveolar Macrophages by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD286 / TLR6 Control Peptide

CD286 / TLR6
0.1 mg / €250.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

CD286 / TLR6 Rabbit IgG Aff - Purified Fe, Hu, Ms, Por Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CD286 / TLR6 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TLR6 antibody (C-term) (AP11536PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD286 / TLR6 (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

CD286 / TLR6 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Mouse TLR6 antibody (C-term) (AP11538PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P
0.4 ml / €370.00
  Acris Antibodies GmbH

CD286 / TLR6 Control Peptide

CD286 / TLR6
50 µg / €160.00
  Acris Antibodies GmbH

CD286 / TLR6 Control Peptide

CD286 / TLR6
50 µg / €160.00
  Acris Antibodies GmbH

CD286 / TLR6 antibody

CD286 / TLR6 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD286 / TLR6 antibody

Detection limit for recombinant GST tagged TLR6 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 4E4 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Items 1 to 20 of 49 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn