CD288 / TLR8 antibody

Principal name

CD288 / TLR8 antibody

Alternative names for CD288 / TLR8 antibody

Toll-like receptor 8, UNQ249/PRO286

SwissProt ID

P58682 (Mouse), Q9NR97 (Human)

Gene ID

51311 (TLR8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of CD288 / TLR8 antibody

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

General readings

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD288 / TLR8 (750-850) antibody

AM08388PU-N at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded brain cortex. Mouse IgG1 44C143 Purified Hu, Ms F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 488 Hu F, ICC/IF
50 µg / €390.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 488 Hu F, ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 546 Hu ICC/IF
50 µg / €390.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 546 Hu ICC/IF
0.1 mg / €520.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 647 Hu F
50 µg / €390.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Alexa Fluor 647 Hu F
0.1 mg / €520.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Biotin Hu WB
50 µg / €360.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Biotin Hu WB
0.1 mg / €480.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Purified Hu C, F, WB
50 µg / €330.00
  Dendritics SAS

CD288 / TLR8 antibody

IF staining of human lung cancer frozen section with 303F1 (DDX0480) Mouse IgG2a 303F1.14 Purified Hu C, F, WB
0.1 mg / €440.00
  Dendritics SAS

CD288 / TLR8 (Center) antibody

Western blot analysis of TLR8 in Daudi cell lysates with TLR8 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 (N-term) antibody

Immunohistochemistry of TLR8 in human thymus tissue with TLR8 antibody at 5 ug/mL. Rabbit IgG Aff - Purified Hu E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 (C-term) antibody

Immunohistochemistry of TLR8 in human thymus tissue with TLR8 antibody at 5 ug/mL. Rabbit IgG Aff - Purified Hu E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TLR8 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and liver cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using TLR8 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 antibody

Western blot analysis of NCI-H460 cell lysate using TLR8 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD288 / TLR8 antibody

Western blot analysis of TLR8 in Daudi cell lysates with TLR8 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml Rabbit IgG Aff - Purified Hu, Ms C, P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD288 / TLR8 antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD288 / TLR8 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Lung, Alveolar Macrophages. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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